Comparative study on xanthan gum and hydroxypropylmethyl cellulose asmatrices for controlled-release drug delivery. II. Drug diffusion in hydrated matrices

International Journal of Pharmaceutics

Volumn 151, Issue 1, 1997, Pages 99-107

  Talukdar, Mohammad Mahiuddin ^a   Kinget, Renaat ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Caffeine; Controlled release; Drug diffusion; Hydrated matrices; Hydroxypropylmethyl cellulose; Indomethacin; Indomethacin sodium; Xanthan gum

Indexed keywords

CAFFEINE; HYDROXYPROPYLMETHYLCELLULOSE; INDOMETACIN; POLYMER; XANTHAN;

ARTICLE; CONTROLLED RELEASE FORMULATION; DIFFUSION COEFFICIENT; DRUG DIFFUSION; DRUG RELEASE; MATRIX TABLET; PRIORITY JOURNAL;

EID: 0030972809     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)04896-5     Document Type: Article

References (16)

1. Alderman, D.A., A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int. J. Pharm. Tech. Prod. Manuf., 5(3) (1984) 1-9.
2. Colombo, P., Bettini, R., Massimo, G., Catellani, P.L., Santi, P. and Peppas, N.A., Drug diffusion front movement is important in drug release control from swellable matrix tablets. J. Pharm. Sci., 84(8) (1995) 991-997.
3. Doelker, E., Water-swollen cellulose derivatives in pharmacy. In Peppas, N.A. (Eds.), Hydrogels in Medicine and Pharmacy, Vol. II, CRC Press, Boca Raton, FL, 1987, pp. 115-160.
4. Fares, H.M. and Zatz, J.L., Measurement of drug release from topical gels using two types of apparatus. Pharm. Technol., 19 (1995) 52-58.
5. Gao, P. and Fagerness, P.E., Diffusion in HPMC Gels. Pharm. Res., 12(7) (1995) 955-964.
6. Gao, P. and Meury, R.H., Swelling of hydroxypropyl methyl-cellulose matrix tablets. 1. Characterization of swelling using a novel optical imaging method. J. Pharm. Sci., 85(7) (1996) 725-731.
7. Kuu, W., Wood, R.W. and Roseman, T.J., Factors influencing the kinetics of solute release. In: Kydonieus, A. (Eds.), Treatise on Controlled Drug Delivery, Marcel Dekker, New York, 1992; pp. 37-154.
8. Lim, T., Uhl, J.T. and Prud'home, R.K, Rheology of self-associating concentrated xanthan solutions. J. Rheol., 28(4) (1984) 367-379.
9. Mitchell, K., Ford, J.L., Armstrong, D.J., Elliot, P.N.C., Rostron, C. and Hogan, J.E., The influence of concentration on the release of drugs from gels and matrices containing Methocel. Int. J. Pharm., 100 (1993) 155-163.
10. Phillips, R.J., Deen, W.M. and Brady, J.F., Hindered transport in fibrous membranes and gels: effect of solute size and fiber configuration. J. Colloid Interface Sci., 139(2) (1990) 363-373.
11. Reinhart, C.T. and Peppas, N.A., Solute diffusion in swollen membranes. II. Influence of crosslinking on diffusive properties. J. Membr. Sci., 18 (1984) 227-239.
12. Talukdar, M.M. and Kinget, R., Swelling and drug release behaviour of xanthan gum matrix tablets. Int. J. Pharm., 120 (1995) 63-72.
13. Talukdar, M.M., Michoel, A., Rombaut, P. and Kinget, R., Comparative study on xanthan gum and hydroxypropylmethyl cellulose as matrices for controlled-release drug delivery. I. Compaction and in-vitro drug release behaviour. Int. J. Pharm., 129 (1996a) 233-241.
14. Talukdar, M.M., Vinckier, I., Moldenaers, P. and Kinget, R., Rheological characterization of xanthan gum and hydroxypropylmethyl cellulose with respect to controlled-release drug delivery. J. Pharm. Sci., 85(5) (1996b) 537-540.
15. Talukdar, M.M., Rombaut, P. and Kinget, R., On the release mechanism of an oral controlled-release delivery system for indomethacin. Pharm. Dev. Technol., (1996c) submitted.
16. Westrin, B.A., Axelsson A. and Zacchi, G., Diffusion measurement in gels. J. Control. Release, 30 (1994)189-199.