Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI

American Journal of Physiology - Renal Physiology

Volumn 285, Issue 6 54-6, 2003, Pages

  Nielsen, Jakob ^a   Kwon, Tae Hwan ^a,b   Praetorius, Jeppe ^a   Kim, Young Hee ^a   Frøkiær, Jørgen ^a   Knepper, Mark A ^c   Nielsen, Søren ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Dongguk University College of Medicine   (South Korea)

^c Laboratory of Kidney and Electrolyte Metabolism NHBLI   (United States)

Author keywords

Aldosterone; Collecting duct; Epithelial sodium channel; Hypertension; Nephrogenic diabetes insipidus; Sodium reabsorption; Sodium wasting

Indexed keywords

ALDOSTERONE; AMILORIDE; AQUAPORIN 2; AQUAPORIN 3; LITHIUM; SODIUM CHANNEL; THIAZIDE DIURETIC AGENT;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIETARY INTAKE; HYPERTENSION; IMMUNOHISTOCHEMISTRY; KIDNEY COLLECTING TUBULE; KIDNEY CONCENTRATING CAPACITY; KIDNEY FUNCTION; MALE; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SODIUM ABSORPTION; SODIUM BALANCE; SODIUM EXCRETION; SODIUM INTAKE;

EID: 0242713052     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00118.2003     Document Type: Article

References (51)

1. - cotransporter abundance: role of aldosterone. J Am Soc Nephrol 12: 1335-1341, 2001.
2. Almeida AJ and Burg MB. Sodium transport in the rabbit connecting tubule. Am J Physiol Renal Fluid Electrolyte Physiol 243: F330-F334, 1982.
3. Angrist BM, Gershon S, Levitan SJ, and Blumberg AG. Lithium-induced diabetes insipidus-like syndrome. Compr Psychiatry 11: 141-146, 1970.
4. + channel by its beta- and gamma-subunits. Am J Physiol Cell Physiol 273: C1889-C1899, 1997.
5. Baer L, Glassman AH, and Kassir S. Negative sodium balance in lithium carbonate toxicity. Evidence of mineralocorticoid blockade. Arch Gen Psychiatry 29: 823-827, 1973.
6. Barker PM, Nguyen MS, Gatzy JT, Grubb B, Norman H, Hummler E, Rossier B, Boucher RC, and Koller B. Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism. J Clin Invest 102: 1634-1640, 1998.
7. Beutler K, Masilamani S, Turban S, Nielsen J, Brooks H, Ageloff S, Fenton R, Packer RK, and Knepper MA. Long-term regulation of ENaC expression in kidney by angiotensin II. Hypertension 41: 1143-1150, 2003.
8. Boton R, Gaviria M, and Batlle DC. Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy. Am J Kidney Dis 10: 329-345, 1987.
9. + channel is made of three homologous subunits. Nature 367: 463-467, 1994.
10. 3H-metolazone. J Am Soc Nephrol 1: 91-98, 1990.
11. Christensen BM, Wang W, Frøkiær J, and Nielsen S. Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin. Am J Physiol Renal Physiol 284: F701-F717, 2003.
12. Christensen S, Kusano E, Yusufi AN, Murayama N, and Dousa TP. Pathogenesis of nephrogenic diabetes insipidus due to chronic administration of lithium in rats. J Clin Invest 75: 1869-1879, 1985.
13. Cogan E, Svoboda M, and Abramow M. Mechanisms of lithium-vasopressin interaction in rabbit cortical collecting tubule. Am J Physiol Renal Fluid Electrolyte Physiol 252: F1080-F1087, 1987.
14. + entry. Am J Physiol Renal Physiol 281: F687-F692, 2001.
15. Ecelbarger CA, Kim GH, Terris J, Masilamani S, Mitchell C, Reyes I, Verbalis JG, and Knepper MA. Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am J Physiol Renal Physiol 279: F46-F53, 2000.
16. Fernandez-Llama P, Andrews P, Nielsen S, Ecelbarger CA, and Knepper MA. Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome. Kidney Int 53: 1244-1253, 1998.
17. Garty H and Palmer LG. Epithelial sodium channels: function, structure, and regulation. Physiol Rev 77: 359-396, 1997.
18. Gold PW, Robertson GL, Post RM, Kaye W, Ballenger J, Rubinow D, and Goodwin FK. The effect of lithium on the osmoregulation of arginine vasopressin secretion. J Clin Endocrinol Metab 56: 295-299, 1983.
19. Hager H, Kwon TH, Vinnikova AK, Masilamani S, Brooks HL, Frøkiær J, Knepper MA, and Nielsen S. Immunocytochemical and immunoelectron microscopic localization of α-, β-, and γ-ENaC in rat kidney. Am J Physiol Renal Physiol 280: F1093-F1106, 2001.
20. Hansen HE, Pedersen EB, and Amdisen A. Renal function and plasma aldosterone during acute lithium intoxication. Acta Med Scand 205: 593-597, 1979.
21. Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, and Lifton RP. Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 11: 76-82, 1995.
22. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, and Rossier BC. Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet 12: 325-328, 1996.
23. Kashgarian M, Biemesderfer D, Caplan M, and Forbush B III. Monoclonal antibody to Na,K-ATPase: immunocytochemical localization along nephron segments. Kidney Int 28: 899-913, 1985.
24. Kim GH, Ecelbarger CA, Mitchell C, Packer RK, Wade JB, and Knepper MA. Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop. Am J Physiol Renal Physiol 276: F96-F103, 1999.
25. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, and Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998.
26. + transporters in rats with lithium-induced NDI. Am J Physiol Renal Physiol 279: F552-F564, 2000.
27. Loffing J, Loffing-Cueni D, Macher A, Hebert SC, Olson B, Knepper MA, Rossier BC, and Kaissling B. Localization of epithelial sodium channel and aquaporin-2 in rabbit kidney cortex. Am J Physiol Renal Physiol 278: F530-F539, 2000.
28. Loffing J, Pietri L, Aregger F, Bloch-Faure M, Ziegler U, Meneton P, Rossier BC, and Kaissling B. Differential subcellular localization of ENaC subunits in mouse kidney in response to high- and low-Na diets. Am J Physiol Renal Physiol 279: F252-F258, 2000.
29. Loffing J, Zecevic M, Feraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, and Verrey F. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol 280: F675-F682, 2001.
30. Marples D, Christensen S, Christensen El, Ottosen PD, and Nielsen S. Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla. J Clin Invest 95: 1838-1845, 1995.
31. Masilamani S, Kim GH, Mitchell C, Wade JB, and Knepper MA. Aldosterone-mediated regulation of ENaC α, β, and γ subunit proteins in rat kidney. J Clin Invest 104: R19-R23, 1999.
32. Masilamani S, Wang X, Kim GH, Brooks H, Nielsen J, Nielsen S, Nakamura K, Stokes JB, and Knepper MA. Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction. Am J Physiol Renal Physiol 283: F648-F657, 2002.
33. May A, Puoti A, Gaeggeler HP, Horisberger JD, and Rossier BC. Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel α subunit in A6 renal cells. J Am Soc Nephrol 8: 1813-1822, 1997.
34. + channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. Proc Natl Acad Sci USA 96: 1727-1731, 1999.
35. Nielsen J, Kwon TH, Masilamani S, Beutler K, Hager H, Nielsen S, and Knepper MA. Sodium transporter abundance profiling in kidney: effect of spironolactone. Am J Physiol Renal Physiol 283: F923-F933, 2002.
36. Palmer LG and Frindt G. Effects of cell Ca and pH on Na channels from rat cortical collecting tubule. Am J Physiol Renal Fluid Electrolyte Physiol 253: F333-F339, 1987.
37. Palmer LG and Frindt G. Conductance and gating of epithelial Na channels from rat cortical collecting tubule. Effects of luminal Na and Li. J Gen Physiol 92: 121-138, 1988.
38. 1 receptors. J Am Soc Nephrol 13: 1131-1135, 2002.
39. Radomski J, Fuyat H, Nelson A, and Smith P. The toxic effects, excretion and distribution of lithium chloride. J Pharmacol Exp Ther 100: 429, 1950.
40. + channels are regulated by flow. Am J Physiol Renal Physiol 280: F1010-F1018, 2001.
41. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR Jr, Ulick S, Milora RV, and Findling JW. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79: 407-414, 1994.
42. + transport. Am J Physiol Renal Fluid Electrolyte Physiol 255: F1269-F1275, 1988.
43. Stokes JB. Ion transport by the cortical and outer medullary collecting tubule. Kidney Int 22: 473-484, 1982.
44. Taylor AN, McIntosh JE, and Bourdeau JE. Immunocytochemical localization of vitamin D-dependent calcium-binding protein in renal tubules of rabbit, rat, and chick. Kidney Int 21: 765-773, 1982.
45. Terris J, Ecelbarger CA, Nielsen S, and Knepper MA. Long-term regulation of four renal aquaporins in rats. Am J Physiol Renal Fluid Electrolyte Physiol 271: F414-F422, 1996.
46. Thomsen K, Bak M, and Shirley DG. Chronic lithium treatment inhibits amiloride-sensitive sodium transport in the rat distal nephron. J Pharmacol Exp Ther 289: 443-447, 1999.
47. Thomsen K, Jensen J, and Olesen OV. Lithium-induced loss of body sodium and the development of severe intoxication in rats. Acta Pharmacol Toxicol (Copenh) 35: 337-346, 1974.
48. Thomsen K, Jensen J, and Olesen OV. Effect of prolonged lithium ingestion on the response to mineralocorticoids in rats. J Pharmacol Exp Ther 196: 463-468, 1976.
49. Thomsen K and Olesen OV. The effect of water deprivation on lithium clearance and lithium excretion fraction in lithium-polyuric rats. J Pharmacol Exp Ther 209: 327-329, 1979.
50. Timmer RT and Sands JM. Lithium intoxication. J Am Soc Nephrol 10: 666-674, 1999.
51. Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, and Rossier BC. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 389: 607-610, 1997.