Hyperphosphorylation and accumulation of neurofilament proteins in transgenic mice with alzheimer presenilin 1 mutation

Cellular and Molecular Neurobiology

Volumn 29, Issue 4, 2009, Pages 497-501

  Yang, Xifei ^a   Yang, Ying ^a   Luo, Yougen ^a   Li, Geng ^b   Wang, Jianzhi ^a   Yang, Edward S ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HONG KONG APPLIED SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE   (Hong Kong)

Author keywords

Alzheimer's disease; Hyperphosphorylation; JNK; Neurofilaments; Presenilin 1

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 9; NEUROFILAMENT PROTEIN; PRESENILIN 1; STRESS ACTIVATED PROTEIN KINASE 1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HIPPOCAMPUS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, TRANSGENIC; NEUROFILAMENT PROTEINS; PHOSPHORYLATION; PRESENILIN-1;

MUS MUSCULUS;

EID: 67449132628     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-008-9341-7     Document Type: Article

References (25)

1. N Arbez V Gautheron B Brugg J Mariani C Rovira 2007 Beta-amyloid(1-42) induces a reduction in the parallel fiber responses of Purkinje cells: possible involvement of pro-inflammatory processes Exp Gerontol 42 951 962 10.1016/j.exger.2007.05.007
2. DR Borchelt G Thinakaran CB Eckman MK Lee F Davenport T Ratovitsky CM Prada G Kim S Seekins D Yager HH Slunt R Wang M Seeger AI Levey SE Gandy NG Copeland NA Jenkins DL Price SG Younkin SS Sisodia 1996 Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo Neuron 17 1005 1013 10.1016/S0896-6273(00)80230-5
3. JF Collard F Côté JP Julien 1995 Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis Nature 375 61 64 10.1038/375061a0
4. P Fernyhough A Gallagher SA Averill JV Priestley L Hounsom J Patel DR Tomlinson 1999 Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy Diabetes 48 881 889 10.2337/diabetes.48.4.881 (Pubitemid 29153090)
5. BJ Gibb JP Brion J Brownlees BH Anderton CC Miller 1998 Neuropathological abnormalities in transgenic mice harbouring a phosphorylation mutant neurofilament transgene J Neurochem 70 492 500 (Pubitemid 28079337)
6. I Grundke-Iqbal K Iqbal YC Tung M Quinlan HM Wisniewski LI Binder 1986 Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proc Natl Acad Sci USA 83 4913 4917 10.1073/pnas.83.13.4913
7. SJ Harper N Wilkie 2003 MAPKs: new targets for neurodegeneration Expert Opin Ther Targets 7 187 200 10.1517/14728222.7.2.187
8. XG Huang BK Yee S Nag ST Chan F Tang 2003 Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235 Exp Neurol 83 673 681 10.1016/S0014-4886(03)00242-5
9. C Jung TB Shea 1999 Regulation of neurofilament axonal transport by phosphorylation in optic axons in situ Cell Motil Cytoskeleton 42 230 240 10.1002/(SICI)1097-0169(1999)42:3<230::AID-CM6>3.0.CO;2-A
10. MK Lee DW Cleveland 1996 Neuronal intermediate filaments Annu Rev Neurosci 19 187 217 10.1146/annurev.ne.19.030196.001155 (Pubitemid 26080827)
11. VM Lee BJ Balin L Otvos Jr JQ Trojanowski 1991 A68: a major subunit of paired helical filaments and derivatized forms of normal Tau Science 251 675 678 10.1126/science.1899488 (Pubitemid 21916893)
12. V Manetto NH Sternberger G Perry LA Sternberger P Gambetti 1988 Phosphorylation of neurofilaments is altered in amyotrophic lateral sclerosis J Neuropathol Exp Neurol 47 642 653 10.1097/00005072-198811000-00007 (Pubitemid 18248671)
13. R Masaki T Saito K Yamada R Ohtani-Kaneko 2000 Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors J Neurosci Res 62 75 83 10.1002/1097-4547(20001001)62:1<75::AID-JNR8>3.0.CO;2-V
14. RA Nixon 1998 The slow axonal transport of cytoskeletal proteins Curr Opin Cell Biol 10 87 92 10.1016/S0955-0674(98)80090-2
15. RA Nixon PA Paskevich RK Sihag CY Thayer 1994 Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber J Cell Biol 126 1031 1046 10.1083/jcb.126.4.1031
16. G Perry N Rizzuto L Autilio-Gambetti P Gambetti 1985 Paired helical filaments from Alzheimer disease patients contain cytoskeletal components Proc Natl Acad Sci USA 82 3916 3920 10.1073/pnas.82.11.3916
17. G Pigino A Pelsman H Mori J Busciglio 2001 Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation J Neurosci 21 834 842 (Pubitemid 32163124)
18. MS Pollanen C Bergeron L Weyer 1994 Characterization of a shared epitope in cortical Lewy body fibrils and Alzheimer paired helical filaments Acta Neuropathol 88 1 6 10.1007/BF00294352
19. M Shoji N Iwakami S Takeuchi M Waragai M Suzuki I Kanazawa CF Lippa S Ono H Okazawa 2000 JNK activation is associated with intracellular beta-amyloid accumulation Brain Res Mol Brain Res 85 221 233 10.1016/S0169-328X(00)00245-X
20. R Starr B Attema GH DeVries MJ Monteiro 1996 Neurofilament phosphorylation is modulated by myelination J Neurosci Res 44 328 337 10.1002/(SICI)1097-4547(19960515)44:4<328::AID-JNR3>3.0.CO;2-E
21. NH Sternberger LA Sternberger J Ulrich 1985 Aberrant neurofilament phosphorylation in Alzheimer disease Proc Natl Acad Sci USA 82 4274 4276 10.1073/pnas.82.12.4274
22. K Tanemura DH Chui T Fukuda M Murayama JM Park T Akagi Y Tatebayashi T Miyasaka T Kimura T Hashikawa Y Nakano T Kudo M Takeda A Takashima 2006 Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1) J Biol Chem 281 5037 5041 10.1074/jbc.M509145200
23. RE Tanzi DM Kovacs TW Kim RD Moir SY Guenette W Wasco 1996 The gene defects responsible for familial Alzheimer's disease Neurobiol Dis 3 159 168 10.1006/nbdi.1996.0016
24. M Yao TV Nguyen CJ Pike 2005 Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w J Neurosci 25 1149 1158 10.1523/JNEUROSCI.4736-04.2005
25. X Zhu HG Lee AK Raina G Perry MA Smith 2002 The role of mitogen-activated protein kinase pathways in Alzheimer's disease Neurosignals 11 270 281 10.1159/000067426