메뉴 건너뛰기




Volumn 182, Issue 11, 2009, Pages 7146-7154

Miltefosine promotes IFN-γ-dominated anti-leishmanial immune response

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 12; MILTEFOSINE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C; STAT1 PROTEIN; ANTIPROTOZOAL AGENT; DRUG DERIVATIVE; INTERFERON RECEPTOR; PHOSPHORYLCHOLINE; STAT1 PROTEIN, HUMAN;

EID: 67449123024     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803859     Document Type: Article
Times cited : (111)

References (55)
  • 2
    • 0036195689 scopus 로고    scopus 로고
    • Leishmaniasis: Recognition and management with a focus on the immuno-compromised patient
    • Choi, C. M., and E. A. Lerner. 2002. Leishmaniasis: recognition and management with a focus on the immuno-compromised patient. Am. J. Clin. Dermatol. 3: 91-105.
    • (2002) Am. J. Clin. Dermatol. , vol.3 , pp. 91-105
    • Choi, C.M.1    Lerner, E.A.2
  • 4
    • 0024390509 scopus 로고
    • Hexadecylphosphocholine, a new ether lipid analogue. Studies on the antineoplastic activity in vitro and in vivo
    • Unger, C., W. Damenz, E. A. Fleer, D. J. Kim, A. Breiser, P. Hilgard, J. Engel, G. Nagel, and H. Eibl. 1989. Hexadecylphosphocholine, a new ether lipid analogue: studies on the anti-neoplastic activity in vitro and in vivo. Acta Oncol. 28: 213-217. (Pubitemid 19159628)
    • (1989) Acta Oncologica , vol.28 , Issue.2 , pp. 213-217
    • Unger, C.1    Damenz, W.2    Fleer, E.A.M.3    Kim, D.J.4    Breiser, A.5    Hilgard, P.6    Engel, J.7    Nagel, G.8    Eibl, H.9
  • 5
    • 0023186694 scopus 로고
    • The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani
    • Croft, S. L., R. A. Neal, W. Pendergast, and J. H. Chan. 1987. The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani. Biochem. Pharmacol. 36: 2633-2636.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 2633-2636
    • Croft, S.L.1    Neal, R.A.2    Pendergast, W.3    Chan, J.H.4
  • 6
    • 0034048702 scopus 로고    scopus 로고
    • Visceral leishmanicidal activity of hexadecyl-phosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms
    • Murray, H. W., and S. Delph-Etienne. 2000. Visceral leishmanicidal activity of hexadecyl-phosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms. J. Infect. Dis. 181: 795-799.
    • (2000) J. Infect. Dis. , vol.181 , pp. 795-799
    • Murray, H.W.1    Delph-Etienne, S.2
  • 8
    • 0032484959 scopus 로고    scopus 로고
    • The inhibition of cell signaling pathways by anti-tumor ether lipids
    • Arthur, G., and R. Bittman. 1998. The inhibition of cell signaling pathways by anti-tumor ether lipids. Biochim. Biophys. Acta 1390: 85-102.
    • (1998) Biochim. Biophys. Acta , vol.1390 , pp. 85-102
    • Arthur, G.1    Bittman, R.2
  • 9
    • 0029620193 scopus 로고
    • Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumor cells
    • Berkovic, D., U. Grunwald, W. Menzel, C. Unger, W. Hiddemann, and E. A. Fleer. 1995. Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumor cells. Eur. J. Cancer 31: 2080-2085.
    • (1995) Eur. J. Cancer , vol.31 , pp. 2080-2085
    • Berkovic, D.1    Grunwald, U.2    Menzel, W.3    Unger, C.4    Hiddemann, W.5    Fleer, E.A.6
  • 10
    • 0035024396 scopus 로고    scopus 로고
    • Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice
    • Escobar, P., V. Yardley, and S. L. Croft. 2001. Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice. Antimicrob. Agents Chemother. 45: 1872-1875.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1872-1875
    • Escobar, P.1    Yardley, V.2    Croft, S.L.3
  • 11
    • 0028842367 scopus 로고
    • Influence of hexadecylphosphocholine on the release of tumor necrosis factor and nitroxide from peritoneal macrophages in vitro
    • Zeisig, R., M. Rudolf, I. Eue, and D. Arndt. 1995. Influence of hexadecylphosphocholine on the release of tumor necrosis factor and nitroxide from peritoneal macrophages in vitro. J. Cancer Res. Clin. Oncol. 121: 69-75.
    • (1995) J. Cancer Res. Clin. Oncol. , vol.121 , pp. 69-75
    • Zeisig, R.1    Rudolf, M.2    Eue, I.3    Arndt, D.4
  • 12
    • 0025830896 scopus 로고
    • Investigation into the immunological effects of miltefosine, a new anticancer agent under development
    • Hilgard, P., E. Kampherm, L. Nolan, J. Pohl, and T. Reissmann. 1991. Investigation into the immunological effects of miltefosine, a new anticancer agent under development. J. Cancer Res. Clin. Oncol. 117: 403-408.
    • (1991) J. Cancer Res. Clin. Oncol. , vol.117 , pp. 403-408
    • Hilgard, P.1    Kampherm, E.2    Nolan, L.3    Pohl, J.4    Reissmann, T.5
  • 13
    • 0026591104 scopus 로고
    • Hexadecylphosphocholine induces IFN-γ secretion and expression of GM-CSF mRNA in human mononuclear cells
    • Hochhuth, C. H., K. Vehmeyer, H. Eibl, and C. Unger. 1992. Hexadecylphosphocholine induces IFN-γ secretion and expression of GM-CSF mRNA in human mononuclear cells. Cell Immunol. 141: 161-168.
    • (1992) Cell Immunol. , vol.141 , pp. 161-168
    • Hochhuth, C.H.1    Vehmeyer, K.2    Eibl, H.3    Unger, C.4
  • 14
    • 0036844173 scopus 로고    scopus 로고
    • Hexadecylphosphocholine selectively up-regulates expression of intercellular adhesion molecule-1 and class-I major histocompatibility complex antigen in human monocytes
    • Eue, I. 2002. Hexadecylphosphocholine selectively up-regulates expression of intercellular adhesion molecule-1 and class-I major histocompatibility complex antigen in human monocytes. J. Exp. Ther. Oncol. 2: 333-336.
    • (2002) J. Exp. Ther. Oncol. , vol.2 , pp. 333-336
    • Eue, I.1
  • 15
    • 0031826253 scopus 로고    scopus 로고
    • The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis
    • Constantinescu, C. S., B. D. Hondowicz, M. M. Elloso, M. Wysocka, G. Trinchieri, and P. Scott. 1998. The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis. Eur. J. Immunol. 28: 2227-2233.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2227-2233
    • Constantinescu, C.S.1    Hondowicz, B.D.2    Elloso, M.M.3    Wysocka, M.4    Trinchieri, G.5    Scott, P.6
  • 16
  • 17
    • 21644436805 scopus 로고    scopus 로고
    • Leishmania inhibits STAT1-mediated IFN-γ signaling in macrophages: Increased tyrosine phosphorylation of dominant negative STAT1β by Leishmania mexicana
    • Bhardwaj, N., L. E. Rosas, W. P. Lafuse, and A. R. Satoskar. 2005. Leishmania inhibits STAT1-mediated IFN-γ signaling in macrophages: increased tyrosine phosphorylation of dominant negative STAT1β by Leishmania mexicana. Int. J. Parasitol. 35: 75-82.
    • (2005) Int. J. Parasitol. , vol.35 , pp. 75-82
    • Bhardwaj, N.1    Rosas, L.E.2    Lafuse, W.P.3    Satoskar, A.R.4
  • 18
    • 0026080768 scopus 로고
    • Immunobiological studies in experimental visceral leishmaniasis, I: Changes in lymphoid organs and their possible roles in pathogenesis
    • Saha, B., H. N. Roy, A. Pakrashi, R. N. Chakraborty, and S. Roy. 1991. Immunobiological studies in experimental visceral leishmaniasis, I: changes in lymphoid organs and their possible roles in pathogenesis. Eur. J. Immunol. 21: 577-581.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 577-581
    • Saha, B.1    Roy, H.N.2    Pakrashi, A.3    Chakraborty, R.N.4    Roy, S.5
  • 19
    • 0037460059 scopus 로고    scopus 로고
    • CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response
    • Awasthi, A., R. K. Mathur, A. A. Khan, B. N. Joshi, N. Jain, S. Sawant, D. Mitra, and B. Saha. 2003. CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response. J. Exp. Med. 197: 1037-1043.
    • (2003) J. Exp. Med. , vol.197 , pp. 1037-1043
    • Awasthi, A.1    Mathur, R.K.2    Khan, A.A.3    Joshi, B.N.4    Jain, N.5    Sawant, S.6    Mitra, D.7    Saha, B.8
  • 20
    • 0026735026 scopus 로고
    • Immunobiological studies in experimental visceral leishmaniasis, II: Adherent cell-mediated down-regulation of delayed-type hypersensitivity response and up-regulation of B cell activation
    • Basak, S. K., B. Saha, A. Bhattacharya, and S. Roy. 1992. Immunobiological studies in experimental visceral leishmaniasis, II: adherent cell-mediated down-regulation of delayed-type hypersensitivity response and up-regulation of B cell activation. Eur. J. Immunol. 22: 2041-2045.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2041-2045
    • Basak, S.K.1    Saha, B.2    Bhattacharya, A.3    Roy, S.4
  • 21
    • 33749136432 scopus 로고    scopus 로고
    • IL-2 is a key cytokine that regulates susceptibility to Leishmania infection
    • Bodas, M., N. Jain, A. Awasthi, B. Ramanamurthy, and B. Saha. 2006. IL-2 is a key cytokine that regulates susceptibility to Leishmania infection. J. Immunol. 177: 4636-4643.
    • (2006) J. Immunol. , vol.177 , pp. 4636-4643
    • Bodas, M.1    Jain, N.2    Awasthi, A.3    Ramanamurthy, B.4    Saha, B.5
  • 22
    • 0029945194 scopus 로고    scopus 로고
    • Protection against lethal toxic shock by targeted disruption of the CD28 gene
    • Saha, B., D. M. Harlan, C. H. June, K. P. Lee, and R. Abe. 1996. Protection against lethal toxic shock by targeted disruption of the CD28 gene. J. Exp. Med. 183: 2675-2680.
    • (1996) J. Exp. Med. , vol.183 , pp. 2675-2680
    • Saha, B.1    Harlan, D.M.2    June, C.H.3    Lee, K.P.4    Abe, R.5
  • 23
    • 2442635429 scopus 로고    scopus 로고
    • Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
    • Erratum in: Nat. Med. 2004.10: 755
    • Mathur, R. K., A. Awasthi, P. Wadhone, B. Ramanamurthy, and B. Saha. 2004. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat. Med. 10: 540-544. Erratum in: Nat. Med. 2004.10: 755.
    • (2004) Nat. Med. , vol.10 , pp. 540-544
    • Mathur, R.K.1    Awasthi, A.2    Wadhone, P.3    Ramanamurthy, B.4    Saha, B.5
  • 24
    • 33750838719 scopus 로고    scopus 로고
    • Functional dichotomy in CD40 reciprocally regulates effector T cell functions
    • Murugaiyan, G., R. Agrawal, G. C. Mishra, D. Mitra, and B. Saha. 2006. Functional dichotomy in CD40 reciprocally regulates effector T cell functions. J. Immunol. 177: 6642-6649. (Pubitemid 44715027)
    • (2006) Journal of Immunology , vol.177 , Issue.10 , pp. 6642-6649
    • Murugaiyan, G.1    Agrawal, E.2    Mishra, G.C.3    Mitra, D.4    Salia, B.5
  • 25
    • 33846904768 scopus 로고    scopus 로고
    • Differential CD40/CD40L expression results in counteracting antitumor immune responses
    • Murugaiyan, G., R. Agrawal, G. C. Mishra, D. Mitra, and B. Saha. 2007. Differential CD40/CD40L expression results in counteracting anti-tumor immune responses. J. Immunol. 178: 2047-2055. (Pubitemid 46233401)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2047-2055
    • Murugaiyan, G.1    Agrawal, R.2    Mishra, G.C.3    Mitra, D.4    Saha, B.5
  • 26
    • 0029083603 scopus 로고
    • Macrophage- T cell interaction in experimental visceral leishmaniasis: Failure to express costimulatory molecules on Leishmania-infected macrophages and its implication in the suppression of cell-mediated immunity
    • Saha, B., G. Das, H. Vohra, N. K. Ganguly, and G. C. Mishra. 1995. Macrophage- T cell interaction in experimental visceral leishmaniasis: failure to express costimulatory molecules on Leishmania-infected macrophages and its implication in the suppression of cell-mediated immunity. Eur. J. Immunol. 25: 2492-2498.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2492-2498
    • Saha, B.1    Das, G.2    Vohra, H.3    Ganguly, N.K.4    Mishra, G.C.5
  • 27
    • 0032744175 scopus 로고    scopus 로고
    • Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-γ-triggered JAK2 activation
    • Blanchette, J., N. Racette, R. Faure, K. A. Siminovitch, and M. Olivier. 1999. Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-γ-triggered JAK2 activation. Eur. J. Immunol. 29: 3737-3744.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 3737-3744
    • Blanchette, J.1    Racette, N.2    Faure, R.3    Siminovitch, K.A.4    Olivier, M.5
  • 28
    • 0031763013 scopus 로고    scopus 로고
    • Identification of radicicol as an inhibitor of in vivo Ras/Raf interaction with the yeast two-hybrid screening system
    • Ki, S. W., K. Kasahara, H. J. Kwon, J. Eishima, K. Takesako, J. A. Cooper, M. Yoshida, and S. Horinouchi. 1998. Identification of radicicol as an inhibitor of in vivo Ras/Raf interaction with the yeast two-hybrid screening system. J. Antibiot. 51: 936-944.
    • (1998) J. Antibiot. , vol.51 , pp. 936-944
    • Ki, S.W.1    Kasahara, K.2    Kwon, H.J.3    Eishima, J.4    Takesako, K.5    Cooper, J.A.6    Yoshida, M.7    Horinouchi, S.8
  • 30
    • 0028834557 scopus 로고
    • Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte- macrophage colony stimulating factor
    • Scheid, M. P., R. W. Lauener, and V. Duronio. 1995. Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor. Biochem J. 312: 159-162.
    • (1995) Biochem J. , vol.312 , pp. 159-162
    • Scheid, M.P.1    Lauener, R.W.2    Duronio, V.3
  • 31
    • 0030911399 scopus 로고    scopus 로고
    • Endogenous interleukin-12 regulates acquired resistance in experimental visceral leishmaniasis
    • Murray, H. W. 1997. Endogenous interleukin-12 regulates acquired resistance in experimental visceral leishmaniasis. J. Infect. Dis. 175: 1477-1479.
    • (1997) J. Infect. Dis. , vol.175 , pp. 1477-1479
    • Murray, H.W.1
  • 32
    • 0031937065 scopus 로고    scopus 로고
    • Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani
    • Engwerda, C. R., M. L. Murphy, S. E. Cotterell, S. C. Smelt, and P. M. Kaye. 1998. Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani. Eur. J. Immunol. 28: 669-680.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 669-680
    • Engwerda, C.R.1    Murphy, M.L.2    Cotterell, S.E.3    Smelt, S.C.4    Kaye, P.M.5
  • 33
    • 0033214404 scopus 로고    scopus 로고
    • Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection
    • Ahuja, S. S., R. L. Reddick, N. Sato, E. Montalbo, V. Kostecki, W. Zhao, M. J. Dolan, P. C. Melby, and S. K. Ahuja. 1999. Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection. J. Immunol. 163: 890-897.
    • (1999) J. Immunol. , vol.163 , pp. 890-897
    • Ahuja, S.S.1    Reddick, R.L.2    Sato, N.3    Montalbo, E.4    Kostecki, V.5    Zhao, W.6    Dolan, M.J.7    Melby, P.C.8    Ahuja, S.K.9
  • 34
    • 0027988291 scopus 로고
    • Leishmania major-parasitized macrophages augment Th2-type T cell activation
    • Chakkalath, H. R., and R. G. Titus. 1994. Leishmania major-parasitized macrophages augment Th2-type T cell activation. J. Immunol. 153: 4378-4387.
    • (1994) J. Immunol. , vol.153 , pp. 4378-4387
    • Chakkalath, H.R.1    Titus, R.G.2
  • 35
    • 28044469320 scopus 로고    scopus 로고
    • Treatment options for visceral leishmaniasis: A systematic review of clinical studies done in India, 1980-2004
    • Olliaro, P. L., P. J. Guerin, S. Gerstl, A. A. Haaskjold, J. A. Rottingen, and S. Sundar. 2005. Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004. Lancet Infect. Dis. 5: 763-774.
    • (2005) Lancet Infect. Dis. , vol.5 , pp. 763-774
    • Olliaro, P.L.1    Guerin, P.J.2    Gerstl, S.3    Haaskjold, A.A.4    Rottingen, J.A.5    Sundar, S.6
  • 36
    • 0001291741 scopus 로고
    • Successful response to chemotherapy in experimental visceral leishmaniasis: Requirement for T cells and effect of lymphokines
    • Murray, H. W., M. J. Oca, A. M. Granger, and R. D. Schreiber. 1989. Successful response to chemotherapy in experimental visceral leishmaniasis: requirement for T cells and effect of lymphokines. J. Clin. Invest. 83: 1254-1259.
    • (1989) J. Clin. Invest. , vol.83 , pp. 1254-1259
    • Murray, H.W.1    Oca, M.J.2    Granger, A.M.3    Schreiber, R.D.4
  • 37
    • 29444452265 scopus 로고    scopus 로고
    • Treatment of visceral leishmaniasis
    • Sundar, S., and M. Rai. 2005. Treatment of visceral leishmaniasis. Expert Opin. Pharmacother. 6: 2821-2829.
    • (2005) Expert Opin. Pharmacother. , vol.6 , pp. 2821-2829
    • Sundar, S.1    Rai, M.2
  • 38
    • 33745196673 scopus 로고    scopus 로고
    • Current scenario of drug development for leishmaniasis
    • Croft, S. L., K. Seifert, and V. Yardley. 2006. Current scenario of drug development for leishmaniasis. Indian J. Med. Res. 123: 399-410.
    • (2006) Indian J. Med. Res. , vol.123 , pp. 399-410
    • Croft, S.L.1    Seifert, K.2    Yardley, V.3
  • 41
    • 0346690405 scopus 로고    scopus 로고
    • Role of CD40 ligand dysregulation in HIV-associated dysfunction of antigen-presenting cells
    • Chougnet, C. 2003. Role of CD40 ligand dysregulation in HIV-associated dysfunction of antigen-presenting cells. J. Leukocyte Biol. 74: 702-709.
    • (2003) J. Leukocyte Biol. , vol.74 , pp. 702-709
    • Chougnet, C.1
  • 42
    • 1442349131 scopus 로고    scopus 로고
    • Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes
    • Paris, C., P. M. Loiseau, C. Bories, and J. Breard. 2004. Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Antimicrob. Agents Chemother. 48: 852-859.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 852-859
    • Paris, C.1    Loiseau, P.M.2    Bories, C.3    Breard, J.4
  • 44
    • 0031280072 scopus 로고    scopus 로고
    • B7-2 blockade enhances T cell responses to Leishmania donovani
    • Murphy, M. L., C. R. Engwerda, P. M. Gorak, and P. M. Kaye. 1997. B7-2 blockade enhances T cell responses to Leishmania donovani. J. Immunol. 159: 4460-4466.
    • (1997) J. Immunol. , vol.159 , pp. 4460-4466
    • Murphy, M.L.1    Engwerda, C.R.2    Gorak, P.M.3    Kaye, P.M.4
  • 45
    • 0008238929 scopus 로고
    • Kinetics of γ interferon binding and induction of major histocompatibility complex class II mRNA in Leishmania-infected macrophages
    • Reiner, N. E., W. Ng, T. Ma, and W. R. McMaster. 1988. Kinetics of γ interferon binding and induction of major histocompatibility complex class II mRNA in Leishmania-infected macrophages. Proc. Natl. Acad. Sci. USA 85: 4330-4334.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 4330-4334
    • Reiner, N.E.1    Ng, W.2    Ma, T.3    McMaster, W.R.4
  • 46
    • 0028326103 scopus 로고
    • + effector cells default to the Th2 pathway in interferon γ-deficient mice infected with Leishmania major
    • + effector cells default to the Th2 pathway in interferon γ-deficient mice infected with Leishmania major. J. Exp. Med. 179: 1367-1371.
    • (1994) J. Exp. Med. , vol.179 , pp. 1367-1371
    • Wang, Z.E.1    Reiner, S.L.2    Zheng, S.3    Dalton, D.K.4    Locksley, R.M.5
  • 47
    • 0033789875 scopus 로고    scopus 로고
    • Essential role of platelet-activating factor in the control of Leishmania amazonensis infection
    • Valdrinez, M., C. Lonardoni, R. Momtchillo, and S. Jancar. 2000. Essential role of platelet-activating factor in the control of Leishmania amazonensis infection. Infect. Immun. 68: 6355-6361.
    • (2000) Infect. Immun. , vol.68 , pp. 6355-6361
    • Valdrinez, M.1    Lonardoni, C.2    Momtchillo, R.3    Jancar, S.4
  • 48
    • 33750315763 scopus 로고    scopus 로고
    • Platelet activating factor receptor-deficient mice present delayed interferon-γ upregualtion and high susceptibility to Leishmania amazonensis infection
    • Santiago, H. C., M. F. B. Pires, D. G. Souza, E. Roffe, D. F. Cortes, W. L. Tafuri, M. M. Teixeira, and L. Q. Vieira. 2006. Platelet activating factor receptor-deficient mice present delayed interferon-γ upregualtion and high susceptibility to Leishmania amazonensis infection. Microbes Infect. 8: 2569-2577.
    • (2006) Microbes Infect. , vol.8 , pp. 2569-2577
    • Santiago, H.C.1    Pires, M.F.B.2    Souza, D.G.3    Roffe, E.4    Cortes, D.F.5    Tafuri, W.L.6    Teixeira, M.M.7    Vieira, L.Q.8
  • 49
    • 55149104592 scopus 로고    scopus 로고
    • In vivo activity of perifosine against Leishmania amazonensis
    • Cabrera-Serra, M. G., B. Valladares, and J. E. Pinero. 2008. In vivo activity of perifosine against Leishmania amazonensis. Acta Trop. 108: 20-25.
    • (2008) Acta Trop. , vol.108 , pp. 20-25
    • Cabrera-Serra, M.G.1    Valladares, B.2    Pinero, J.E.3
  • 50
    • 0033758270 scopus 로고    scopus 로고
    • Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether-lipid analogues in Leishmania
    • Lux, H., N. Heise, T. Klenner, D. Hart, and F. R. Opperdoes. 2000. Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether-lipid analogues in Leishmania. Mol. Biochem. Parasitol. 111: 1-14.
    • (2000) Mol. Biochem. Parasitol. , vol.111 , pp. 1-14
    • Lux, H.1    Heise, N.2    Klenner, T.3    Hart, D.4    Opperdoes, F.R.5
  • 51
    • 33845240370 scopus 로고    scopus 로고
    • Aspects of the cytological activity of edelfosine miltefosine, and ilmofosine in Leishmania donovani
    • Azzouz, S., M. Maache, M. F. Dos Santos, M. E. Sarciron, A. F. Petavy, and A. Osuna. 2006. Aspects of the cytological activity of edelfosine, miltefosine, and ilmofosine in Leishmania donovani. J. Parasitol. 92: 877-883.
    • (2006) J. Parasitol. , vol.92 , pp. 877-883
    • Azzouz, S.1    Maache, M.2    Dos Santos, M.F.3    Sarciron, M.E.4    Petavy, A.F.5    Osuna, A.6
  • 53
    • 6344244521 scopus 로고    scopus 로고
    • Effects of the lysophospholipid analogue edelfosine ilmofosine and miltefosine against Leishmania amazonensis
    • Santa-Rita, R. M., A. Henriques-Pons, H. S. Barbosa, and S. L. de Castro. 2004. Effects of the lysophospholipid analogue edelfosine, ilmofosine and miltefosine against Leishmania amazonensis. J. Antimicrob. Chemother. 54: 704-710.
    • (2004) J. Antimicrob. Chemother. , vol.54 , pp. 704-710
    • Santa-Rita, R.M.1    Henriques-Pons, A.2    Barbosa, H.S.3    De Castro, S.L.4
  • 54
    • 0036150927 scopus 로고    scopus 로고
    • Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edel-fosine) and amphotericin B
    • Escober, P., S. Matu, C. Marques, and S. L. Croft. 2002. Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edel-fosine) and amphotericin B. Acta Trop. 81: 151-157.
    • (2002) Acta Trop. , vol.81 , pp. 151-157
    • Escober, P.1    Matu, S.2    Marques, C.3    Croft, S.L.4
  • 55
    • 38349004478 scopus 로고    scopus 로고
    • The antitumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across plasma membrane of human KB carcinoma cells
    • Munoz-Martinez, F., C. Torres, S. Castanys, and F. Gamarro. 2008. The antitumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across plasma membrane of human KB carcinoma cells. Biochim. Biophys. Acta 1778: 530-540.
    • (2008) Biochim. Biophys. Acta , vol.1778 , pp. 530-540
    • Munoz-Martinez, F.1    Torres, C.2    Castanys, S.3    Gamarro, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.