Structure-activity relationship at the leucine side chain in a series of N,N-dialkyldipeptidyl-amines as N-type calcium channel blockers

Drug Design and Discovery

Volumn 16, Issue 4, 2000, Pages 317-322

  Ryder, Todd R ^a   Hu, Lain Yen ^a   Rafferty, Michael F ^a   Lotarski, Susan M ^a   Rock, David M ^a   Stoehr, Sally J ^a   Taylor, Charles P ^a   Weber, Mark L ^a   Miljanich, George P ^b   Millerman, Elizabeth ^b   Szoke, Balazs G ^b  

^a PFIZER INC   (United States)

^b ELAN PHARMACEUTICALS   (United States)

Author keywords

N type calcium channel blockers

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; LEUCINE; N,N DIALKYLDIPEPTIDYL AMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; DRUG DESIGN; DRUG SOLUBILITY; ELECTROPHYSIOLOGY; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKANES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; DIPEPTIDES; ELECTROPHYSIOLOGY; LEUCINE; OLIGOPEPTIDES; OMEGA-CONOTOXINS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 6744266653     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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