Sublingual immunotherapy for children: Are we there yet?. Defining its role in clinical practice

Paediatric Respiratory Reviews

Volumn 10, Issue 2, 2009, Pages 69-74

  Campbell, Dianne E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

allergen; allergic rhinitis; asthma; children; immunotherapy; sublingual

Indexed keywords

ALLERGEN; EOSINOPHIL CATIONIC PROTEIN; GRASS POLLEN EXTRACT; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 19; INTERLEUKIN 4; INTERLEUKIN 5; PLACEBO; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC RHINITIS; ASTHMA; CHILD; CHILD HEALTH CARE; CLINICAL PRACTICE; CLINICAL TRIAL; CYTOKINE PRODUCTION; DERMATOPHAGOIDES; DISEASE COURSE; DRUG APPROVAL; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG SAFETY; EUROPE; EVIDENCE BASED MEDICINE; FOOD AND DRUG ADMINISTRATION; GASTROINTESTINAL DISEASE; HEALTH CARE COST; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOTHERAPY; INSECT ALLERGY; MOUTH EDEMA; ORAL PRURITUS; PATIENT COMPLIANCE; PHLEUM PRATENSE; PLACEBO EFFECT; POSTMARKETING SURVEILLANCE; PRIORITY JOURNAL; REVIEW; SENSITIZATION; T LYMPHOCYTE; TABLET FORMULATION; TH1 CELL; TH2 CELL; TREATMENT OUTCOME;

ADMINISTRATION, SUBLINGUAL; ALLERGENS; ASTHMA; CHILD; HUMANS; IMMUNOTHERAPY; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; TREATMENT OUTCOME;

EID: 67349286956     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2009.02.003     Document Type: Review

References (45)

1. Ross R.N., Nelson H.S., and Finegold I. Effectiveness of specific immunotherapy in the treatment of hymenoptera venom hypersensitivity: a meta-analysis. Clin Ther 22 (2000 Mar) 351-358
2. Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S. Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev 2007:CD001936.
3. Abramson MJ, Puy RM, Weiner JM. Allergen immunotherapy for asthma. Cochrane Database Syst Rev 2000:CD001186.
4. Bousquet J., Van Cauwenberge P., and Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108 5 Suppl (2001 Nov) S147-334
5. Ortolani C., Agostinis F., Amoroso S., Ariano R., Barbato A., Bassi M., et al. Practice parameters for sublingual immunotherapy. Monaldi Arch Chest Dis 65 (2006 Mar) 44-46
6. Moller C., Dreborg S., Ferdousi H.A., Halken S., Host A., Jacobsen L., et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 109 (2002 Feb) 251-256
7. Jacobsen L., Niggemann B., Dreborg S., Ferdousi H.A., Halken S., Host A., et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy 62 (2007 Aug) 943-948
8. Des Roches A., Paradis L., Menardo J.L., Bouges S., Daures J.P., and Bousquet J. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol 99 (1997 Apr) 450-453
9. Pajno G.B., Barberio G., De Luca F., Morabito L., and Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. six -year follow-up study. Clin Exp Allergy 31 (2001 Sep) 1392-1397
10. Di Rienzo V., Marcucci F., Puccinelli P., Parmiani S., Frati F., Sensi L., et al. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin Exp Allergy 33 (2003 Feb) 206-210
11. Novembre E., Galli E., Landi F., Caffarelli C., Pifferi M., De Marco E., et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 114 (2004 Oct) 851-857
12. Marogna M., Tomassetti D., Bernasconi A., Colombo F., Massolo A., Businco A.D., et al. Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study. Ann Allergy Asthma Immunol 101 (2008 Aug) 206-211
13. Ozdemir C., Yazi D., Gocmen I., Yesil O., Aydogan M., Semic-Jusufagic A., et al. Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma. Pediatr Allergy Immunol 18 (2007 Sep) 508-515
14. Passalacqua G., and Durham S.R. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol 119 (2007 Apr) 881-891
15. Antunez C., Mayorga C., Corzo J.L., Jurado A., and Torres M.J. Two year follow-up of immunological response in mite-allergic children treated with sublingual immunotherapy. Comparison with subcutaneous administration. Pediatr Allergy Immunol 19 (2008 May) 210-218
16. Savolainen J., Nieminen K., Laaksonen K., Laiho T., Jacobsen L., Lahesmaa R., et al. Allergen-induced in vitro expression of IL-18, SLAM and GATA-3 mRNA in PBMC during sublingual immunotherapy. Allergy 62 (2007 Aug) 949-953
17. Nouri-Aria K.T., Wachholz P.A., Francis J.N., Jacobson M.R., Walker S.M., Wilcock L.K., et al. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol 172 (2004 Mar 1) 3252-3259
18. Marcucci F., Sensi L., Di Cara G., Salvatori S., Bernini M., Pecora S., et al. Three-year follow-up of clinical and inflammation parameters in children monosensitized to mites undergoing sub-lingual immunotherapy. Pediatr Allergy Immunol 16 (2005 Sep) 519-526
19. Wilson A.M., O'Byrne P.M., and Parameswaran K. Leukotriene receptor antagonists for allergic rhinitis: a systematic review and meta-analysis. Am J Med 116 (2004 Mar 1) 338-344
20. Chapman M.D. Allergen nomenclature. Clin Allergy Immunol 21 (2008) 47-58
21. Bousquet J., Lockey R., and Malling H.J. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol 102 4 Pt 1 (1998 Oct) 558-562
22. Nelson H.S. Allergen immunotherapy: where is it now?. J Allergy Clin Immunol 119 (2007 Apr) 769-779
23. Wilson D.R., Lima M.T., and Durham S.R. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 60 (2005 Jan) 4-12
24. Olaguibel J.M., and Alvarez Puebla M.J. Efficacy of sublingual allergen vaccination for respiratory allergy in children. Conclusions from one meta-analysis. J Investig Allergol Clin Immunol 15 (2005) 9-16
25. Penagos M., Compalati E., Tarantini F., Baena-Cagnani R., Huerta J., Passalacqua G., et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol 97 (2006 Aug) 141-148
26. Valovirta E., Jacobsen L., Ljorring C., Koivikko A., and Savolainen J. Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children. Allergy 61 (2006 Oct) 1177-1183
27. Roder E., Berger M.Y., Hop W.C., Bernsen R.M., de Groot H., and Gerth van Wijk R. Sublingual immunotherapy with grass pollen is not effective in symptomatic youngsters in primary care. J Allergy Clin Immunol 119 (2007 Apr) 892-898
28. Roder E., Berger M.Y., de Groot H., and van Wijk R.G. Immunotherapy in children and adolescents with allergic rhinoconjunctivitis: a systematic review. Pediatr Allergy Immunol 19 (2008 May) 197-207
29. Calamita Z., Saconato H., Pela A.B., and Atallah A.N. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy 61 (2006 Oct) 1162-1172
30. Penagos M., Passalacqua G., Compalati E., Baena-Cagnani C.E., Orozco S., Pedroza A., et al. Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest 133 (2008 Mar) 599-609
31. Khinchi M.S., Poulsen L.K., Carat F., Andre C., Hansen A.B., and Malling H.J. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Allergy 59 (2004 Jan) 45-53
32. Cox L.S., Linnemann D.L., Nolte H., Weldon D., Finegold I., and Nelson H.S. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol 117 (2006 May) 1021-1035
33. Passalacqua G., Guerra L., Compalati E., and Canonica G.W. The safety of allergen specific sublingual immunotherapy. Curr Drug Saf 2 (2007 May) 117-123
34. Rienzo V.D., Minelli M., Musarra A., Sambugaro R., Pecora S., Canonica W.G., et al. Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years. Clin Exp Allergy 35 (2005 May) 560-564
35. Blazowski L. Anaphylactic shock because of sublingual immunotherapy overdose during third year of maintenance dose. Allergy 63 (2008 Mar) 374
36. Eifan A.O., Keles S., Bahceciler N.N., and Barlan I.B. Anaphylaxis to multiple pollen allergen sublingual immunotherapy. Allergy 62 (2007 May) 567-568
37. Dunsky E.H., Goldstein M.F., Dvorin D.J., and Belecanech G.A. Anaphylaxis to sublingual immunotherapy. Allergy 61 (2006 Oct) 1235
38. Antico A., Pagani M., and Crema A. Anaphylaxis by latex sublingual immunotherapy. Allergy 61 (2006 Oct) 1236-1237
39. Moreno C., Cuesta-Herranz J., Fernandez-Tavora L., and Alvarez-Cuesta E. Immunotherapy safety: a prospective multi-centric monitoring study of biologically standardized therapeutic vaccines for allergic diseases. Clin Exp Allergy 34 (2004 Apr) 527-531
40. Bernstein D.I., Wanner M., Borish L., and Liss G.M. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001. J Allergy Clin Immunol 113 (2004 Jun) 1129-1136
41. Bonnin A.J., and Zacharias D.M. Sublingual immunotherapy. N Engl J Med 359 (2008 Aug 21) 869-870
42. Passalacqua G., Musarra A., Pecora S., Amoroso S., Antonicelli L., Cadario G., et al. Quantitative assessment of the compliance with once-daily sublingual immunotherapy in children (EASY project: evaluation of a novel SLIT formulation during a year). Pediatr Allergy Immunol 18 (2007 Feb) 58-62
43. Pajno G.B., Vita D., Caminiti L., Arrigo T., Lombardo F., Incorvaia C., et al. Children's compliance with allergen immunotherapy according to administration routes. J Allergy Clin Immunol 116 (2005 Dec) 1380-1381
44. Berto P., Bassi M., Incorvaia C., Frati F., Puccinelli P., Giaquinto C., et al. Cost effectiveness of sublingual immunotherapy in children with allergic rhinitis and asthma. Eur Ann Allergy Clin Immunol 37 (2005 Oct) 303-308
45. BMJ Group. Grazax for hay fever?. Drug Ther Bull 46 (2008) 9-10