Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-Year follow-up on the PAT study

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 62, Issue 8, 2007, Pages 943-948

  Jacobsen, L ^a,b   Niggemann, B ^c   Dreborg, S ^d   Ferdousi, H A ^e   Halken, S ^f   Host A ^g   Koivikko, A ^h   Norberg, L A ^g   Valovirta, E ^h   Wahn, U ^c   Moller C ⁱ  

^a ALK Abelló ^*  (Denmark)

^b ALK ABELLÓ   (Denmark)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e LINKÖPING UNIVERSITY   (Sweden)

^f Anæstesiologisk Center   (Denmark)

^g ODENSE UNIVERSITY HOSPITAL   (Denmark)

^h Turku Allergy Center   (Finland)

ⁱ UMEÅ UNIVERSITY   (Sweden)

Author keywords

Asthma; Long term effect; Prevention; Rhinitis; Specific immunotherapy

Indexed keywords

ALLERGEN; ALUTARD; AQUAGEN SQ; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; LEVOCABASTINE; LORATADINE; METHACHOLINE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ALLERGIC CONJUNCTIVITIS; ARTICLE; ASTHMA; BIRCH; BRONCHUS HYPERREACTIVITY; CLINICAL EVALUATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GRASS POLLEN; HUMAN; IMMUNOTHERAPY; INHALATION TEST; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PEDIATRICS; POLLEN ALLERGY; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; RHINOCONJUNCTIVITIS; SPECIFIC IMMUNOTHERAPY;

ADOLESCENT; ADULT; ALLERGENS; ASTHMA; BETULA; BRONCHIAL PROVOCATION TESTS; DESENSITIZATION, IMMUNOLOGIC; FEMALE; FOLLOW-UP STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; ODDS RATIO; PAIN MEASUREMENT; PLANT PROTEINS; POACEAE; POLLEN; RHINITIS, ALLERGIC, SEASONAL; RISK FACTORS; SKIN TESTS; TIME;

EID: 34447132918     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2007.01451.x     Document Type: Article

References (26)

1. Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol 2002 109 : 419 425.
2. Leynaert B, Neukirch F, Demoly P, Bousquet J. Epidemiologic evidence for asthma and rhinitis comorbidity. J Allergy Clin Immunol 2000 5 (Suppl. S201 S205.
3. Bauer CP. Untersuchung zur Asthmaprävention durch die specifische Immuntherapie bei Kindern. Allergologie 1993 11 : 468.
4. Grembiale RD, Camporota L, Naty S, Tranfa CM, Djukanovic R, Marsico SA. Effects of specific immunotherapy in allergic rhinitic individuals with bronchial hyperresponsiveness. Am J Respir Crit Care Med 2000 162 : 2048 2052.
5. Jacobsen L, Nuchel PB, Wihl JA, Lowenstein H, Ipsen H. Immunotherapy with partially purified and standardized tree pollen extracts. IV. Results from long-term (6-year) follow-up. Allergy 1997 52 : 914 920.
6. Johnstone DE, Dutton A. The value of hyposensitization therapy for bronchial asthma in children-a 14-year study. Pediatrics 1968 42 : 793 802.
7. Novembre E, Galli E, Landi F, Caffarelli C, Pifferi M, De ME et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 2004 114 : 851 857.
8. Moller C, Dreborg S, Ferdousi HA, Halken S, Host A, Jacobsen L et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 2002 109 : 251 256.
9. Niggemann B, Jacobsen L, Dreborg S, Ferdousi HA, Halken S, Host A et al. Five-year follow up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy 2006 61 : 855 859.
10. Moller C, Bjorksten B, Nilsson G, Dreborg S. The precision of the conjunctival provocation test. Allergy 1984 39 : 37 41.
11. Matthys H, Knoch M, Eltschka R. A new aerosol device for bronchial provocation tests. Respiration 1993 60 : 343 350.
12. Woodcock A, Lowe LA, Murray CS, Simpson BM, Pipis SD, Kissen P et al. Early life environmental control - effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med 2004 170 : 433 439.
13. Cullinan P, MacNeill SJ, Harris JM, Moffat S, White C, Mills P et al. Early allergen exposure, skin prick responses, and atopic wheeze at age 5 in English children: a cohort study. Thorax 2004 59 : 855 861.
14. Burr M, Emberlin JC, Treu R, Cheng S, Pearce N, ISAAC Phase One Study Group. Pollen counts in relation to the prevalence of allergic rhinoconjunctivitis, asthma and atopic eczema in the International study of asthma and allergies in childhood (ISAAC). Clin Exp Allergy 2003 33 : 1675 1680.
15. Holt PG, Sly PD, Bjorksten B, Wahn U, Loh R. Prophylaxis of atopy and asthma in children. http://www.immunetolerance.org/research/allergy/trials/ holt_tr.html#top ; accessed 3 May 2007.
16. Allergic factors associated with the development of asthma and the influence of cetirizine in a double-blind, randomised, placebo-controlled trial: first results of ETAC. Early treatment of the atopic child. Pediatr Allergy Immunol 1998 9 : 116 124.
17. Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 2006 354 : 1985 1997.
18. Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 2006 354 : 1998 2005.
19. Mosbech H, Osterballe O. Does the effect of immunotherapy last after termination of treatment? Follow-up study in patients with grass pollen rhinitis. Allergy 1988 43 : 523 529.
20. Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 1999 12 : 341.
21. Des RA, Paradis L, Knani J, Hejjaoui A, Dhivert H, Chanez P et al. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract/ V. Duration of the efficacy of immunotherapy after its cessation. Allergy 1996 51 : 430 433.
22. Hedlin G, Heilborn H, Lilja G, Norrlind K, Pegelow K, Schou C et al. Long-term follow-up of patients treated with a three-year course of cat or dog immunotherapy. J Allergy Clin Immunol 1995 96 : 879 885.
23. Eng PA, Borer-Reinhold M, Heijnen IA, Gnehm HP. Twelve-year follow-up after discontinuation of preseasonal grass pollen immunotherapy in childhood. Allergy 2006 61 : 198 201.
24. Ulrik CS, Backer V. Longitudinal determinants of bronchial responsiveness to inhaled histamine. Chest 1998 113 : 973 979.
25. Burrows B, Sears MR, Flannery EM, Herbison GP, Holdaway MD, Silva PA. Relation of the course of bronchial responsiveness from age 9 to age 15 to allergy. Am J Respir Crit Care Med 1995 152 (4 Pt 1) : 1302 1308.
26. Halken S. Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention. Pediatr Allergy Immunol 2004 15 (Suppl. 16 4 32.