Abnormal energy regulation in early life: Childhood gene expression may predict subsequent chronic mountain sickness

BMC Pediatrics

Volumn 8, Issue , 2008, Pages

  Huicho, Luis ^a   Xing, Guoqiang ^b   Qualls, Clifford ^c   Rivera Ch, María ^a   Gamboa, Jorge L ^d   Verma, Ajay ^e   Appenzeller, Otto ^c  

^a UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; PYRUVATE DEHYDROGENASE COMPLEX; TRICARBOXYLIC ACID; DIOXYGENASE; EGLN3 PROTEIN, HUMAN; HEMOGLOBIN A; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; UNCLASSIFIED DRUG;

ADOLESCENT; ALTITUDE DISEASE; ARTICLE; CHILD; CITRIC ACID CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC SUSCEPTIBILITY; GLYCOLYSIS; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; LEUKOCYTE; NUCLEOTIDE SEQUENCE; OXYGEN SATURATION; ADAPTATION; ADULT; ALTITUDE; ANOXIA; CHRONIC DISEASE; CROSS-SECTIONAL STUDY; ENERGY METABOLISM; GENETICS; HEMOGLOBIN AA; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREDICTION AND FORECASTING; PRESCHOOL CHILD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTATION, PHYSIOLOGICAL; ADOLESCENT; ADULT; ALTITUDE; ALTITUDE SICKNESS; ANOXIA; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; CITRIC ACID CYCLE; CROSS-SECTIONAL STUDIES; DIOXYGENASES; ENERGY METABOLISM; GENE EXPRESSION; GLYCOLYSIS; HEMATOCRIT; HEMOGLOBIN A; HUMANS; MALE; PREDICTIVE VALUE OF TESTS; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 56049127712     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/1471-2431-8-47     Document Type: Article

References (25)

1. Moore LGHuman genetic adaptation to high altitude High Alt Med Biol 2001, 2:257-79 11443005
2. Beall CM Tibetan and Andean patterns of adaptation to high-altitude hypoxia Hum Biol 2000, 72:201-28 10721618
3. Niermeyer S Yang P Shanmina Drolkar Zhuang J Moore LG Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet N Engl J Med 1995, 333:1248-52 7566001
4. Moore LG Armaza F Villena M Vargas E Comparative aspects of high-altitude adaptation in human populations Adv Exp Med Biol 2000, 475:45-62 10849648
5. Beall CM Decker MJ Brittenham GM Kushner I Gebremedhin A Strohl KP An Ethiopian pattern of human adaptation to high-altitude hypoxia Proc Natl Acad Sci USA 2002, 99:17215-8 139295 12471159
6. Hochachka PW Gunga HC Kirsch K Our ancestral physiological phenotype: An adaptation for hypoxia tolerance and for endurance performance? Proc Natl Acad Sci USA 1998, 95:1915-20 19213 9465117
7. Goebel T Waters MR O'Rourke DH The late Pleistocene dispersal of modern humans in the Americas Science 2008, 319:1497-1502 18339930
8. Monge C Chronic mountain sickness Physiol Rev 1943, 23:166-84
9. Ergueta J Spielvogel H Cudkowicz L Cardio-respiratory studies in chronic mountain sickness (Monge's syndrome) Respiration 1971, 28:485-517 5140341
10. Beall CM Brittenham GM Strohl KP Blangero J Williams-Blangero S Goldstein MC Decker MJ Vargas E Villena M Soria R Alarcon AM Gonzales C Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara Am J Phys Anthropol 1998, 106:385-400 9696153
11. Xing G Qualls C Huicho L Rivera-Ch M Stobdan T Slessarev M Prisman E Ito S Wu H Norboo A Dolma D Kunzang M Norboo T Gamboa JL Claydon VE Fisher J Zenebe G Gebremedhin A Hainsworth R Verma A Appenzeller O Adaptation and mal-adaptation to ambient hypoxia: Andean, Ethiopian and Himalayan patterns PLoS ONE 2008, 3:e2342 2396283 18523639
12. Huicho L Postnatal cardiopulmonary adaptations to high altitude Respir Physiol Neurobiol 2007, 158:190-203 17573246
13. Frisancho AR Developmental adaptation to high altitude hypoxia Int J Biometeorol 1997, 21:135-46
14. Rupert JL Hochachka PW The evidence for hereditary factors contributing to high altitude adaptation in Andean natives: A review High Alt Med Biol 2001, 2:235-56 11443004
15. Moore LG Niermeyer S Zamudio S Human adaptation to high altitude: regional and life-cycle perspectives Am J Phys Anthropol 1998, (Suppl 27):25-64 9881522
16. Moore LG Niermeyer S Vargas E Does chronic mountain sickness (CMS) have perinatal origins? Respir Physiol Neurobiol 2007, 158:180-9 17706469
17. Semenza GL Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1 Biochem J 2007, 405:1-9 17555402
18. Papandreou I Cairns RA Fontana L Lin Lim A Denko NC HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metab 2006, 3:187-97 16517406
19. Rivera-Ch M León-Velarde F Huicho L Treatment of chronic mountain sickness: Critical reappraisal of an old problem Respir Physiol Neurobiol 2007, 158:251-65 17580125
20. Bakonyi T Radak Z High altitude and free radicals J Sports Science Med 2004, 3:64-9
21. Hartzell HC Cell biology. The stress of relaxation Science 2007, 317:1331-2 17823336
22. Burgoyne JR Madhani M Cuello F Charles RL Brennan JP Schröder E Browning DD Eaton P Cysteine redox sensor in PKGIa enables oxidant-induced activation Science 2007, 317:1393-7 17717153
23. Jaenisch R Bird A Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals Nature Genet 2003, (Suppl):245-54 12610534
24. Bird A Perceptions of epigenetics Nature 2007, 447:396-8 17522671
25. Appenzeller O Minko T Qualls C Pozharov V Gamboa J Gamboa A Wang Y Gene expression, autonomic function and chronic hypoxia:lEssons from the Andes Clin Auton Res 2006, 16:217-22 16583294