Characterization of ultrasound-mediated destruction of drug-loaded microbubbles using an improved in vitro model

Applied Acoustics

Volumn 70, Issue 10, 2009, Pages 1323-1329

  Tinkov, Steliyan ^a   Bekeredjian, Raffi ^b   Winter, Gerhard ^a   Coester, Conrad ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acoustic destructibility; Drug loading; Microbubble contrast agents; Ultrasound

Indexed keywords

BODY TEMPERATURE; CELL SHAPES; CONTRAST AGENT; DEAD VOLUMES; DRUG-LOADING; EXPERIMENTAL SETUP; GENE DELIVERY; IN-VITRO; MECHANICAL AGITATION; MEMBRANE CELLS; MICROBUBBLE CONTRAST AGENTS; MICROBUBBLES; OPTIMAL FLOWS; PARTICLE DIAMETERS; PHOSPHOLIPID MONOLAYERS; PHYSIOLOGICAL CONDITION; SILICONE MEMBRANE; SITE-SPECIFIC; THEORETICAL MODELS; TIME INTERVAL; TRIACETIN; ULTRASOUND; ULTRASOUND EXPOSURE;

ACOUSTIC WAVES; BLOOD PRESSURE; CELL MEMBRANES; GENE TRANSFER; MEDICAL IMAGING; MICROEMULSIONS; MONOLAYERS; OPTIMIZATION; PHOSPHOLIPIDS; PHYSIOLOGICAL MODELS; SILICONES; ULTRASONIC TRANSMISSION; ULTRASONICS;

ULTRASONIC IMAGING;

EID: 67349282988     PISSN: 0003682X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apacoust.2008.10.007     Document Type: Article

References (23)

1. Sheikov N., McDannold N., Vykhodtseva N., Jolesz F., and Hynynen K. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol 30 (2004) 979-989
2. Stieger S., Caskey C.F., Adamson R.H., Qin S., Curry F.R., Wisner E.R., et al. Enhancement of vascular permeability with low-frequency contrast-enhanced ultrasound in the chorioallantoic membrane model. Radiology 243 1 (2007) 112-121
3. Li P., Cao L.Q., Dou C.Y., Armstrong W.F., and Miller D. Impact of myocardial contrast echocardiography on vascular permeability: an in vivo dose response study of delivery mode, pressure amplitude and contrast dose. Ultrasound Med Biol 29 9 (2003) 1341-1349
4. Marmottant P, Hilgenfeldt S, Versluis M, Gardeniers H, van den Berg A, Lohse D. Cell permeabilisation and transport focused around oscillating microbubbles. In: XXI ICTAM, Warsaw, Poland; 15th-21st August 2004.
5. Shimamura M., Sato N., Taniyama Y., Yamamoto S., Endoh M., Kurinami H., et al. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Ther 11 (2004) 1532-1539
6. Borden M, Dayton P, Zhao S, Ferrara KW. Physico-chemical properties of the microbubble lipid shell. In: IEEE trans ultrason ferroelectr freq control proc; 2004.
7. Bloch S., Wan M., Dayton P.A., and Ferrara K.W. Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents. Appl Phys Lett 84 4 (2004) 631-633
8. Mehier-Humbert S., Yan F., Frinking P., Schneider M., Guy R.H., and Bettinger T. Ultrasound-mediated gene delivery: influence of contrast agent on transfection. Bioconjugate Chem 18 (2007) 652-662
9. Unger E., McCreery T.P., Sweitzer R.H., Caldwell V.E., and Wu Y. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest Radiol 33 12 (1998) 886-892
10. Shortencarier Tartis M., McCallan J., Lum A.F., LaBell R., Stieger S.M., Matsunaga T.O., et al. Therapeutic effects of paclitaxel-containing ultrasound contrast agents. Ultrasound Med Biol 32 11 (2006) 1771-1780
11. May D, Allen J, Gut J, Ferrara KW, Acoustic fragmentation of therapeutic contrast agents designed for localized drug delivery. In: IEEE ultras symp proc; 2001.
12. Shortencarier M., Dayton P.A., Bloch S.H., Schumann P.A., Matsunaga T.O., and Ferrara K.W. A method for radiation-force localized drug delivery using gas-filled lipospheres. IEEE Trans Ultrason Ferroelectr Freq Control 51 7 (2004) 822-831
13. Kinoshita T. The method to determine the optimum refractive index parameter in the laser diffraction and scattering method. Adv Powder Technol 12 4 (2001) 589-602
14. Lazewatsky J, Kagan M, Barrett J. The effect of dilution medium on the measurement of in vitro properties of ultrasound contrast agents. In: IEEE ultras symp proc; 1999.
15. Marsh J., Hall C.S., Wickline S.A., and Lanza G.M. Temperature dependence of acoustic impedance for specific fluorocarbon liquids. J Acoust Soc Am 112 6 (2002) 2858-2862
16. Apfel R., and Holland C.K. Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound. Ultrasound Med Biol 17 (1991) 179-185
17. Holland C., and Apfel R.E. An improved theory for the prediction of microcavitation thresholds. IEEE Trans Ultrason Ferroelectr Freq Control Proc 36 2 (1989) 204-208
18. Greis C. Technology overview: sonovue (Bracco, Milan). Eur Radiol Suppl 14 Suppl. 8 (2004) 11-15
19. Moran C., Anderson T., Pye S.D., Sboros V., and McDicken W.N. Quantification of microbubble destruction of three fluorocarbon-filled ultrasonic contrast agents. Ultrasound Med Biol 26 4 (2000) 629-639
20. Marsh J., Hall C.S., Scott M.J., Fuhrhop R.W., Gaffney P.J., Wickline S.A., et al. Improvements in the ultrasonic contrast of targeted perfluorocarbon nanoparticles using an acoustic transmission line model. IEEE Trans Ultrason Ferroelectr Freq Control 49 1 (2002) 29-38
21. Hoff L. Acoustic characterization of Nycomed's NC100100 contrast agent. In: IEEE ultras symp proc; 1998. p. 1799-802.
22. Caskey C, Stieger SM, Qin S, Dayton PA, Ferrara KW. Microbubble oscillations in gel phantom and ex vivo preparation validate proposed mechanisms for contrast-based drug delivery. In: IEEE ultras symp proc; 2007. p. 769-72.
23. Caskey C., Kruse D.E., and Dayton P.A. Microbubble oscillation in tubes with diameters of 12, 25, and 195 microns. Appl Phys Lett 88 033902 (2006) 1-3