Physico-chemical properties of the microbubble lipid shell: Composition, microstructure & properties of targeted ultrasound contrast agents

Proceedings - IEEE Ultrasonics Symposium

Volumn 1, Issue , 2004, Pages 20-23

  Borden, Mark A ^a   Dayton, Paul ^a   Zhao, Shukui ^a   Ferrara, Katherine W ^a  

^a Davis   (United States)

Author keywords

Phospholipid monolayer microstructure; Shell shedding; Targeting ligand location; Ultrasound contrast agent

Indexed keywords

PHOSPHOLIPID MONOLAYER MICROSTRUCTURE; SHELL SHEDDING; TARGETING LIGAND LOCATION; ULTRASOUND CONTRAST AGENT;

HYDROPHOBICITY; MICROSTRUCTURE; MONOLAYERS; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; ULTRASONICS;

BUBBLES (IN FLUIDS);

EID: 21644482792     PISSN: 10510117     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ULTSYM.2004.1417658     Document Type: Conference Paper

References (13)

1. A. L. Klibanov, M. S. Hughes, J. N. Marsh, C. S. Hall, J. G. Miller, J. H. Wiible, and G. H. Brandenburger, "Targeting of ultrasound contrast material - An in vitro feasibility study," Acta Radiologica, vol. 38, pp. 113-120, 1997.
2. P. A. Dayton and K. W. Ferrara, "Targeted imaging using ultrasound," Journal of Magnetic Resonance Imaging, vol. 16. pp. 362-377, 2002.
3. E. C. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi, "Therapeutic applications of lipid-coated microbubbles," Advanced Drug Delivery-Review, vol. 56, pp. 1291-1314, 2004.
4. S. Zhao, M. A. Borden, S. Bloch, D. Kruse, K. W. Ferrara, and P. A. Dayton, "Radiation force assisted targeting facilitates ultrasonic molecular imaging," Molecular Imaging, vol. 13, pp. 1-14, 2004.
5. D. H. Kim, M. J. Costello, P. B. Duncan, and D. Needham, "Mechanical properties and microstructure of polycrystalline phospholipid monolayer shells: Novel solid microparticles," Langmuir, vol. 19, pp. 8455-8466, 2003.
6. M. A. Borden, G. Pu, G. J. Runner, and M. L. Longo, "Surface phase behavior and microstructure of lipid/PEG-emulsifier monolayer-coated microbubbles," Colloids, and Surfaces B-Biointerfaces, vol. 35, pp. 209-223, 2004.
7. D. H. Kim, A. L. Klibanov, and D. Needham, "The influence of tiered layers of surface-grafted poly(ethylenc glycol) on receptor-ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated class beads," Lungmuir, vol. 16, pp. 2808-2817, 2000.
8. |8] M. A. Borden and M. L. Longo, "Dissolution behavior of lipid monolayer-coated, air-filled microbubbles: Effect of lipid hydrophobic chain length," Langmuir, vol. 18, pp. 9225-9233, 2002.
9. M. A. Borden and M. L. Longo, "Oxygen permeability of fully-condensed lipid monolayers," Journal of Physical Chemistry B. vol. 108, pp. 6009-6016, 2004.
10. O. Pu, M. L. Longo, and M. A. Borden, "Dependence of gas permeability on microstructure in fully condensed lipid monolayers," vol. unpublished. 2004.
11. S. A. Vickery and R. C. Dunn, "Direct observation of structural evolution in palmitic acid monolayers following Langmuir-Blodgett deposition," Lungmuir, vol. 17, pp. 8204-8209, 2001.
12. J. E. Chomas, P. Dayton, J. Allen, K. Morgan, and K. W. Ferrara, "Mechanisms of contrast agent destruction," Ieee Transactions on Ultrasonics, Ferroelectrics and Frequency Control, vol. 48, pp. 232-248, 2001.
13. J. A. Zasadzinski, J. Ding, H. E. Warriner, F. Bringezu, and A. J. Waring, "The physics and physiology of lung surfactants," Current Opinion in Colloid & Interface Science, vol. 6, pp. 506-513, 2001.