Tissue-specific expression of the bovine aromatase-encoding gene uses multiple transcriptional start sites and alternative first exons

Endocrinology

Volumn 138, Issue 7, 1997, Pages 2813-2819

  Fürbass, Rainer ^a   Kalbe, Claudia ^a   Vanselow, Jens ^a  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; CYTOCHROME P450;

ADRENAL GLAND; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; COW; DNA FLANKING REGION; EXON; GENE EXPRESSION; GENE STRUCTURE; GRANULOSA CELL; NONHUMAN; PLACENTA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE HOMOLOGY; TESTIS; TRANSCRIPTION INITIATION;

EID: 0030946116     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.7.5257     Document Type: Article

References (34)

1. Goldammer T, Guérin G, Brunner RM, Vanselow J, Fürbass R, Schwerin M 1994 Chromosomal mapping of the bovine aromatase gene (cyp19) and an aromatase pseudogene to chromosome 10 and syntenic group U5. Mammalian Genome 5:826-827
2. Lephart ED, Simpson ER, McPhaul MJ, Kilgore MW, Wilson JD, Ojeda SR 1992 Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal and perinatal development in the rat. Mol Brain Res 16:187-192
3. Mahendroo MS, Mendelson CR, Simpson ER 1993 Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. J Biol Chem 268:19463-19470
4. Conley AJ, Corbin CJ, Hinshelwood MM, Liu Z, Simpson ER, Ford JJ, Harada N 1996 Functional aromatase expression in porcine adrenal gland and testis. Biol Reprod 54:497-505
5. Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ho YJ, Fisher CR, Michael MD, Mendelson CR, Bulun SE 1994 Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 15:342-355
6. Vanselow J, Fürbass R 1995 Novel aromatase transcripts from bovine placenta contain repeated sequence motifs. Gene 154:281-286
7. Hinshelwood MM, Liu Z, Conley AJ, Simpson ER 1995 Demonstration of tissue-specific promoters in nonprimate species that express aromatase P450 in placentae. Biol Reprod 53:1151-1159
8. Honda S, Harada N, Takagi Y 1994 Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain. Biochem Biophys Res Commun 198:1153-1160
9. Yamadamouri N, Hirata S, Kato J 1996 Existence and expression of the untranslated first exon of aromatase mRNA in the rat brain. J Steroid Biochem Mol Biol 58:163-166
10. Honda SI, Harada N, Takagi Y 1996 The alternative exons 1 of the mouse aromatase cytochrome P-450 gene. Bba-Gene Struct Express 1305:145-150
11. Sambrook J, Fritsch EF, Maniatis T 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor
12. Frohman MA 1990 RACE: rapid amplification of cDNA ends. In: Innis MA, Gelfand DH, Sninsky JJ, White TJ (eds) PCR Protocols: A Guide to Methods and Applications. Academic Press, London, pp 28-38
13. Fürbass R, Vanselow J 1995 An aromatase pseudogene is transcribed in the bovine placenta. Gene 154:287-292
14. Shapiro MB, Senapathy P 1987 RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res 15:7155-7174
15. Seyfert H-M, Interthal H, Hahnen J, Koczan D 1993 Definition, distribution, and use of a conserved Bovidae retroposon element sequence motif. Mammalian Genome 4:153-158
16. Javaheri R, Khachi A, Lo K, Zenzie-Gregory B, Smale ST 1994 DNA sequence requirements for transcriptional initiator activity in mammalian cells. Mol Cell Biol 14:116-127
17. Lala DS, Rice DA, Parker KL 1992 Steroidogenic factor 1, a key regulator of steroidogenic enzyme expression is the mouse homolog of fushi tarazu-factor 1. Mol Endocrinol 6:1249-1258
18. Morohashi K, Honda S, Inomata Y, Handa H, Omura T 1992 A common trans-acting factor, Ad4-binding protein, binds to the promoters of steroidogenic P450s. J Biol Chem 267:17913-17919
19. Means GD, Mahendroo MS, Corbin CJ, Mathis JM, Powell FE, Mendelson CR, Simpson ER 1989 Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J Biol Chem 264:19385-19391
20. Toda K, Terashima M, Kawamoto T, Sumimoto H, Yokoyama Y, Kuribayashi I, Mitsuuchi Y, Maeda T, Yamamoto Y, Sagata Y, Ikeda H, Shizuta Y 1990 Structural and functional characterization of human aromatase P-450 gene. Eur J Biochem 193:559-565
21. Corbin CJ, Khalil MW, Conley AJ 1995 Functional ovarian and placental isoforms of porcine aromatase. Mol Cell Endocrinol 113:29-37
22. Fitzpatrick SL, Richards JS 1993 Cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3′,5′-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells. Mol Endocrinol 7:341-354
23. Lynch JP, Lala DS, Peluso JJ, Luo W, Parker KL, White BA 1993 Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol Endocrinol 7:776-786
24. Michael MD, Kilgore MW, Morohashi K, Simpson ER 1995 Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PH) of the human aromatase P450 (CYP19) gene in the ovary. J Biol Chem 270:13561-13566
25. Weis L, Reinberg D 1992 Transcription by RNA polymerase II: initiator-directed formation of transcription-competent complexes. FASEB J 6:3300-3309
26. Roy AL, Meisterernst M, Pognonec P, Roeder RG 1991 Cooperative interaction of an initiator-binding transcription factor and the helix-loop-helix activator USF. Nature 354:245-248
27. Bungert J, Kober F, Düring F, Seifart KH 1992 Transcription factor eUSF is an essential component of isolated transcription complexes on the duck histone H5 gene and it mediates the interaction of TFIID with a TATA-deficient promoter. J Mol Biol 223:885-898
28. Toda K, Akira S, Kishimoto T, Sasaki H, Hashimoto K, Yamamoto Y, Sagara Y, Shizuta Y 1995 Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. Eur J Biochem 231:292-299
29. MacLusky NJ, Walters MJ, Clark AS, Toranallerand CD 1994 Aromatase in the cerebral cortex, hippocampus, and mid-brain: ontogeny and developmental implications. Mol Cell Neurosci 5:691-698
30. Yamada-Mouri N, Hirata S, Hayashi M, Kato J 1995 Analysis of the expression and the first exon of aromatase mRNA in monkey brain. J Steroid Biochem Mol Biol 55:17-23
31. Inkster S, Yue W, Brodie A 1995 Human testicular aromatase: Immunocytochemical and biochemical studies. J Clin Endocrinol Metab 80:1941-1947
32. Bulun SE, Rosenthal IM, Brodie AMH, Inkster SE, Zeller WP, Digeorge AM, Frasier SD, Kilgore MW, Simpson ER 1993 Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads. J Clin Endocrinol Metab 77:1616-1621
33. Stripecke R, Oliveira CC, McCarthy JE, Hentze MW 1994 Proteins binding to 5′ untranslated region sites: a general mechanism for translation regulation of mRNAs in human and yeast cells. Mol Cell Biol 14:5898-5909
34. Roy N, Laflamme G, Raymond V 1992 5′ untranslated sequences modulate rapid mRNA degradation mediated by 3′ AU-rich element in v-/c-fos recombinants. Nucleic Acids Res 20:5753-5762