Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4+ and CD8+ T-cell dysfunction in patients with active SLE

Cellular Immunology

Volumn 258, Issue 1, 2009, Pages 83-89

  Gang, Cai ^a   Jiahui, Yang ^a   Huaizhou, Wang ^a   Qing, Cai ^a   Dongbao, Zhao ^a   Qian, Shen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

IL 2; Inducible costimulator; MAP kinase; Systemic lupus erythematosus

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CD28 ANTIGEN; CYCLOPHOSPHAMIDE; HYDROXYCHLOROQUINE; INDUCIBLE COSTIMULATORY MOLECULE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; STEROID; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LOW DRUG DOSE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; FLAVONOIDS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 67349268444     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2009.03.016     Document Type: Article

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