Merkel cells and Merkel cell carcinoma express the BCL-2 proto-oncogene

Experimental Dermatology

Volumn 5, Issue 2, 1996, Pages 102-107

  Plettenberg, Andreas ^a   Pammer, Johannes ^a   Tschachler, Erwin ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; bcl 2; Merkel cell carcinoma; Merkel cells; Oncogenesis

Indexed keywords

ENDOGENOUS COMPOUND;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MERKEL CELL; PROTO ONCOGENE; SKIN CARCINOMA;

ADULT; AGED; ANTIBODIES, MONOCLONAL; BIOPSY; CARCINOMA, MERKEL CELL; FETUS; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; MERKEL CELLS; MIDDLE AGED; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENES; REFERENCE VALUES; SKIN NEOPLASMS;

EID: 0029989663     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0625.1996.tb00102.x     Document Type: Article

References (21)

1. Cohen J J. Apoptosis. Immunol Today 1993: 14: 126-130.
2. Schwartz L M, Osborne B A. Programmed cell death, apoptosis and killer genes. Immunol Today 1992: 14: 582-590.
3. Vaux D L. Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci USA 1993: 90: 786-789.
4. Korsmeyer S J. Bcl-2: a repressor of lymphocyte death. Immunol Today 1992: 13: 285-288.
5. Nunez G, Clarke M F. The bcl-2 family of proteins: regulators of cell death and survival. Trends in cell biol 1994: 4: 399-403.
6. Reed C J. Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994: 124: 1-6.
7. Buttke T M, Sandstrom P A. Oxidative stress as a mediator of apoptosis. Immunol Today 1994: 15: 7-10.
8. Kane D J, Sarafian T A, Anton R et al. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993: 262: 1274-1277.
9. Ryan J J, Prochownik E, Gottlieb C A et al. C-myc and bcl-2 modulate P53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci USA 1994: 91: 5878-5882.
10. Krajewski S, Tanaka S, Takayama S et al. Investigation of the subcellular distribution of the bcl-2 oncoprotein. Cancer Res 1994: 53: 40701-4714.
11. 2+ fluxes. Proc Natl Acad Sci USA 1991: 91: 6569-6573.
12. Baffy G, Miyashita T, Williamson J R, Red J C. Apoptosis induced by withdrawal of interleukin-3 (IL3) from cell IL3 dependent hematopoitec cell lines is associated with repartitioning of intracellular calcium and is blocked by enforced bcl-2 oncoprotein production. J Biol Chem 1993: 268: 6511-6519.
13. Hockenbery D M, Zuttler M, Hickey.W et al. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991: 88: 6961-6965.
14. leBrun D P, Warnke R A, Clearly M L. Expression of bcl-2 in retal tissues suggests a role in morphogenesis. Am J Pathol 1993: 142: 743-753.
15. Lu Q-L, Poulsom R, Wong L, Hanby A M. Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J Pathol 1993: 169: 431-437.
16. Cerroni L, Kerl H. Aberrant bcl-2 protein expression provides a possible mechanism of neoplastic cell growth in cutaneous basal-cell carcinoma. J Cut Pathol 1994: 21: 398-403.
17. Wrone-Smith T, Johnson T, Nelson B et al. Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo. Am J Pathol 1995: 146: 1079-1088.
18. Rodriguez-Villanueva J, Colome M I, Brisbay S, McDonnell T J. The expression and localization of bcl-2 protein in normal skin and in non-melanoma skin cancers. Path Res Pract 1995: 191: 391-391.
19. Plettenberg A, Ballaun C, Pammer J et al. Human melanocytes and melanoma cells constitutively express the bcl-2 proto-oncogene in situ and in cell culture. Am J Pathol 1995: 146: 651-659.
20. Van den Oord J J, Vandeghinste N, De Ley M, De Wolf-Peeters C. Bcl-2 expression in human melanocytes and melanocytic tumors. Am J Pathol 1994: 145: 294-300.
21. Smoller B R, Van de Riyn M, Lebrun D, Warnke R A. Bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. Br J Dermatol 1994: 131: 28-31.