Role of placenta in the vertical transmission of human immunodeficiency virus

Journal of Perinatology

Volumn 29, Issue 5, 2009, Pages 331-336

  Al Husaini, A M ^a  

^a LUTHERAN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR;

CD4+ T LYMPHOCYTE; CHORION VILLUS; ENDOTHELIUM; GENETIC ANALYSIS; GENETIC SELECTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; PLACENTAL TRANSFER; REVIEW; SEQUENCE ANALYSIS; TROPHOBLAST; VERTICAL TRANSMISSION; VIRUS REPLICATION; VIRUS TRANSMISSION;

CHEMOKINES; FEMALE; FETAL DISEASES; HIV INFECTIONS; HIV-1; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY OUTCOME; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TROPHOBLASTS;

EID: 67349265142     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/jp.2008.187     Document Type: Review

References (56)

1. Fisher S, Genbacev O, Maidji E, Pereira L. Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero implications for transmission and pathogenesis. Virol 2000; 74: 6808-6820.
2. Gabrielli L, Losi L, Varani S, Lazzarotto T, Eusebi V, Landini MP. Complete replication of human cytomegalovirus in explants of first trimester human placenta. J Med Virol 2001; 64: 499-504.
3. Koi H, Zhang J, Parry S. The mechanism of placental viral infection. Ann NY Acad Sci 2001; 943: 148-156.
4. Bhat P, Anderson DA. Hepatitis B virus translocates across a trophoblastic barrier. J Virol 2007; 81(13): 7200-7207.
5. Menu E, Mbopi-Keou FX, Lagaye S, Pissard S, Mauclere P, Scarlatti G et al. Selection of maternal human immunodeficiency virus type 1 variants in human placenta. J Infect Dis 1999; 179: 44-51.
6. Leroy V, Karon JM, Alioum A, Ekpini ER, Meda N, Greenberg AE et al Twenty-four month efficacy of a maternal short-course zidovudine regimen to prevent mother-to-child transmission of HIV-1 in West Africa. AIDS 2002; 16: 631-641.
7. Qian M, Bui T, Ho RJ, Unadkat JD. Metabolism of 3′-azido-3′-deoxythymidine (AZT) in human placental trophoblasts and Hofbauer cells. Biochem Pharmacol 1994; 48(2): 383-389.
8. Burton GJ, O'Shea S, Rostron T, Mullen JE, Aiyer S, Skepper JN et al Significance of placental damage in vertical transmission of human immunodeficiency virus. J Med Virol 1996; 50: 237-243.
9. Chandwani S, Greco MA, Mittal K, Antoine C, Krasinski K, Borkowsky W. Pathology of human immunodeficiency virus expression in placenta of seropositive women. J Infect Dis 1991; 163(5): 1134-1138.
10. Lewis SH, Reynolds-Kohler C, Fox HE, Nelson JA. HIV-1 in trophoblastic and villous Hofbauer cells, and hematologic precursors in eight week fetuses. Lancet 1990; 335: 565.
11. Bagasra O, Bobroski L, Saikumari P, Pestaner JP, Seshamma T, Pomerantz RJ et al. Presence of HIV-1 in placentas of HIV-1 seropositive mothers by in situ PCR. Natl Conf Hum Retroviruses Relat Infect (2nd) 1995; 2: 136.
12. McGann KA, Collman R, Kolson DL, Gonzalez-Scarano F, Coukos G, Coutifaris C et al. Human immunodeficiency virus type 1 causes productive infection of macrophages in primary placental cell cultures. J Infect Dis 1994; 169: 746-753.
13. Kilani RT, Chang LJ, Garcia-Lloret M, Hemmings D, Winkler-Lowen B, Guilbert LJ. Placental trophoblasts resist infection by multiple human immunodeficiency virus (HIV) type 1 variants even with cytomegalovirus coinfection but support HIV replication after provirus transfection. J Virol 1997; 71: 6359-6372.
14. Ishii M, Hayakawa S, Suzuki MK, Yoshino N, Honda M, Nishinarita S et al. Expression of functional chemokine receptors of human placental cells. Am J Reprod Immunol 2000; 44: 365-373.
15. Lagaye S, Derrien M, Menu E, Coïto C, Tresoldi E, Mauclère P. Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasispecies across a trophoblastic barrier by both transcytosis and infection. J Virol 2001; 75 4780-4791.
16. Garcia PM, Kalish LA, Pitt J, Minkoff H, Quinn TC, Burchett KC et al Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. N Engl J Med 1999; 341 394-402.
17. Khouri YF, McIntosh K, Cavacini L, Posner M, Pagano M, Tuomala R et al. Vertical transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 antibodies. J Clin Invest 1995; 95: 732-737.
18. Cao Y, Krogstad P, Korber BT, Koup RA, Muldoon M, Macken C et al. Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the prevention of HIV transmission from mother to infant. Nat Med 1997; 3: 549-552.
19. Pugatch D, Sullivan JL, Pikora CA, Luzuriaga K. Delayed generation of antibodies mediating human immunodeficiency virus type 1-specific antibody-dependent cellular cytotoxicity in vertically infected infants. WITS Study Group. Women and Infants Transmission Study. J Infect Dis 1997; 176: 643-648.
20. Jenkins M, Landers D, Williams-Herman D, Wara D, Viscarello RR, Hammill HA et al. Association between anti-human immunodeficiency virus type 1 (HIV-1) antibody-dependent cellular cytotoxicity antibody titers at birth and vertical transmission of HIV-1. J Infect Dis 1994; 170: 308-312.
21. Mulder-Kampinga GA, Simonon A, Kuiken CL, Dekker J, Scherpbier HJ, van de Perre P et al. Similarity in env and gag genes between genomic RNAs of human immunodeficiency virus type 1 (HIV-1) from mother and infant is unrelated to time of HIV-1 RNA positivity in the child. J Virol 1995; 69: 2285-2296.
22. Harrer T, Harrer E, Kalams SA, Barbosa P, Trocha A, Johnson RP et al Cytotoxic T lymphocytes in asymptomatic long-term no progressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J Immunol 1996; 156: 2616-2623.
23. Rinaldo C, Huang XL, Fan ZF, Ding M, Beltz L, Logar A et al. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J Virol 1995; 69: 5838-5842.
24. Price DA, Goulder PJR, Klenerman P, Sewell AK, Easterbrook PA, Troop M et al. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci USA 1997; 94: 1890-1895.
25. Behbahani H, Popek E, Garcia P, Andersson J, Spetz AL, Landay A et al Up-regulation of CCR5 expression in the placenta is associated with human immunodeficiency virus-1 vertical transmission. Am J Pathol 2000; 157: 1811-1818.
26. Goulder PJ, Phillips RE, Colbert RA, McAdam S, Ogg G, Nowak MA et al Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat Med 1997; 3: 212-217.
27. D'costa GF, Khadke K, Vishwasrao PY. Pathology of placenta in HIV infection. Indian J Pathol Microbiol 2007; 50(3): 515-519.
28. Kwon BS, Tan KB, Ni J, Oh KO, Lee ZH, Kim KK et al. A newly identified member of the tumor necrosis factor receptor super family with a wide tissue distribution and involvement in lymphocyte activation. J Biol Chem 1997; 272: 14272-14276.
29. Ayouba A, Badaut C, Kfutwah A, Cannou C, Juillerat A, Gangnard S et al. Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum. AIDS 2008; 22(6): 785-787.
30. Ramakrishnan R, Mehta R, Sundaravaradan V, Davis T, Ahmad N. Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission. Retrovirology 2006; 3 42.
31. Matala E, Crandall KA, Bker RC, Ahmad N. Limited heterogeneity of HIV-1 in infected mothers correlated with lack of vertical transmission. AIDS Res Hum Retroviruses 2000; 16(15): 1481-1489.
32. Hahn T, Matala E, Cheppry C, Ahmad N. Characterization of mother infant HIV-1 gag p17 sequences associated with perinatal transmission. AIDS Res Hum Retroviruses 1999; 15(10): 875-888.
33. Hahn T, Ahmad N. Genetic characterization of HIV-1 gag p17 matrix genes in isolate from infected mothers lacking perinatal transmission. AIDS Res Hum Retroviruses 2000; 17(17): 1673-1680.
34. Wellensiek BP, Sundaravaradan V, Ramakrishnan R, Ahmad N. Molecular characterization of the HIV-1 gag nucleocapsid gene associated with vertical transmission. Retrovirology 2006; 3: 21.
35. Connor RI, Chen BK, Choe S, Landau NR. vpr is required for efficient replication of human immunodeficiency virus type 1 in mononuclear phagocytes. Virology 1995; 206(2): 935-944.
36. Venkat RKY, Ahmad N. Low conservation of functional domains of HIV type 1 vif and vpr genes in infected mothers correlates with lack of vertical transmission. AIDS Res Hum Retroviruses 2001; 17 (10): 911-923.
37. Venkat RKY, Husain M, Horodner A, Ahmad N. Molecular characterization of HIV type 1 vpu genes from mothers and infants after perinatal transmission. AIDS Res Hum Retroviruses 2001; 17(11): 1089-1098.
38. Husain M, Hahn T, Yedavalli VR, Ahmad N. Characterization of HIV type 1 tat sequences associated with perinatal transmission. AIDS Res Hum Retroviruses 2001; 17: 765-773.
39. Hahn T, Ramakrishnan R, Ahmad N. Evaluation of genetic diversity of human immunodeficiency virus type 1 NEF gene associated with vertical transmission. J Biomed Sci 2003; 10: 436-450.
40. Ramakrishnan R, Husain M, Holzer A, Mehta R, Sundaravaradan V, Ahmad N. Evaluations of HIV type 1 rev gene diversity and functional domains following perinatal transmission. AIDS Res Hum Retroviruses 2005; 21: 1035-1045.
41. Sundaravaradan V, Hahn T, Ahmad N. Conservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmission. Retrovirology 2005; 2: 36.
42. Bourinbaiar AS, Lee-Huang S. Anti-HIV effect of beta subunit of human chorionic gonadotropin (beta hCG) in vitro. Immunol Lett 1995; 44(1): 13-18.
43. Faye A, Pornprasert S, Dolcini G, Ave P, Taïeb J, Taupin JL et al Evaluation of the placental environment with a new in vitro model of histocultures of early and term placentae: Determination of cytokine and chemokine expression profiles. Placenta 2005; 26 262-267.
44. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM et al. CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996; 272: 1955-1958.
45. Jekle A, Keppler OT, De Clercq E, Schols D, Weinstein M, Goldsmith MA. In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells. J Virol 2003; 77: 5846-5854.
46. Newell ML, Peckham C. Risk factor for vertical transmission of HIV-1 and early markers of HIV-1 infection in children. AIDS 1993; 7: S91-S97.
47. Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of seven transmembrane, G protien coupled receptor. Science 1996; 272(5263): 872-877.
48. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD et al. The beta chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996; 85(7): 1135-1845.
49. Westervelt P, Trowbrige DB, Epstein LG, Blumberg BM, Li Y, Hahn BH et al. Acrophage tropism determent of human immunodeficiency virus type-1 in vivo. J Virol 1992; 66: 2577-2582.
50. Philpott S, Burger H, Charbonneau T, Grimson R, Vermund SH, Visosky A et al. CCR5 genotype and resistance to vertical transmission of HIV-1. J Acquir Immune Defic Syndr 1999; 21: 189-193.
51. Bouhlal H, Hocini H, Quillent-Gregoire C, Donkova V, Rose S, Amara A et al. Antibodies to C-C chemokine receptor 5 in normal human IgG block infection of macrophages and lymphocytes with primary R5-tropic strains of HIV-1. J Immunol 2001; 166: 7606-7611.
52. Patterson B, Behbahani H, Kabat WJ, Sullivan Y, Maurice RG, Landay A et al. Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women. J Clin Invest 2001; 107(3): 287-294.
53. Patterson BK, Czerniewski MA, Andersson J, Sullivan Y, Su F, Jiyamapa D et al. Regulation of CCR5 and CXCR4 expression by type 1 and type 2 cytokines: CCR5 expression is downregulated by IL-10 in CD4-positive lymphocytes. Clin Immunol 1999; 91: 254-262.
54. Lee BN, Ordonez N, Popek EJ, Lu JG, Helfgott A, Eriksen N et al. Inflammatory cytokine expression is correlated with the level of human immunodeficiency virus (HIV) transcripts in HIV-infected placental trophoblastic cells. J Virol 1997; 71: 3628-3635.
55. Vidricaire G, Tardif MR, Tremblay MJ. The low viral production in trophoblastic cells is due to a high endocytic internalization of the human immunodeficiency virus type 1 and can be overcome by the proinflammatory cytokines TNF-alpha and IL-1. J Biol Chem 2003; 278: 15832-15841.
56. Zachar V, Fink T, Koppelhus U, Ebbesen P. Role of placental cytokines in transcriptional modulation of HIV type 1 in the isolated villous trophoblast. AIDS Res Hum Retroviruses 2002; 18: 839-847.