Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells

Virus Research

Volumn 143, Issue 1, 2009, Pages 77-85

  Yang, Tsuey Ching ^a   Shiu, Su Lian ^a   Chuang, Pei Hsin ^a   Lin, Ying Ju ^b   Wan, Lei ^b   Lan, Yu Ching ^a   Lin, Cheng Wen ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; ASK1 p38 MAPK pathway; Japanese encephalitis virus; NS2B NS3 protease

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEINASE; PROTEINASE NS2B; PROTEINASE NS3; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVATION; EPIDEMIC ENCEPHALITIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; JAPANESE ENCEPHALITIS VIRUS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS REPLICATION;

APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE; CYTOCHROMES C; ENCEPHALITIS VIRUS, JAPANESE; ENZYME ACTIVATION; HUMANS; MAP KINASE KINASE KINASE 5; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RNA HELICASES; SERINE ENDOPEPTIDASES; VIRAL NONSTRUCTURAL PROTEINS;

JAPANESE ENCEPHALITIS VIRUS;

EID: 67349244347     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2009.03.007     Document Type: Article

References (33)

1. Burk D.S., and Monath T.P. Flaviviruses. In: Knipe D.M., and Howley P.M. (Eds). Fields Virology. 4th ed. (2001), Lippincott-Raven, Philadephia 1043-1125
2. Chen C.J., Chen J.H., Chen S.Y., Liao S.L., and Raung S.L. Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection. J. Virol. 78 (2004) 12107-12119
3. Chen S.O., Chang T.J., Stone G., Chen C.H., and Liu J.J. Programmed cell death induced by Japanese encephalitis virus YL vaccine strain or its recombinant envelope protein in varied cultured cells. Intervirology 49 (2006) 346-351
4. Chiou S.S., and Chen W.J. Mutations in the NS3 gene and 3′-NCR of Japanese encephalitis virus isolated from an unconventional ecosystem and implications for natural attenuation of the virus. Virology 289 (2001) 129-136
5. Ghoshal A., Das S., Ghosh S., Mishra M.K., Sharma V., Koli P., Sen E., and Basu A. Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia 55 (2007) 483-496
6. Hatai T., Matsuzawa A., Inoshita S., Mochida Y., Kuroda T., Sakamaki K., Kuida K., Yonehara S., Ichijo H., and Takeda K. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J. Biol. Chem. 275 (2000) 26576-26581
7. Hsieh C.C., and Papaconstantinou J. Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. FASEB J. 20 (2006) 259-268
8. Huang C.R., Chang W.N., Lui C.C., Wu H.S., and Liou C.W. Neuroimages of Japanese encephalitis: report of three patients. Chin. Med. J. (Taipei) 60 (1997) 105-108
9. Kalita J., and Misra U.K. Comparison of CT and MRI findings in the diagnosis of Japanese encephalitis. J. Neurol. Sci. 174 (2000) 3-8
10. Kuo P.L., Chen C.Y., and Hsu Y.L. Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells. Cancer Res. 67 (2007) 7406-7420
11. Lin C.W., Cheng C.W., Yang T.C., Li S.W., Cheng M.H., Wan L., Lin Y.J., Lai C.H., Lin W.Y., and Kao M.C. Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus Res. 137 (2008) 49-55
12. Lin C.W., Liu K.T., Huang H.D., and Chen W.J. Protective immunity of E. coli-synthesized NS1 protein of Japanese encephalitis virus. Biotechnol. Lett. 30 (2008) 205-214
13. Lin C.W., Huang H.D., Shiu S.Y., Chen W.J., Tsai M.H., Huang S.H., Wan L., and Lin Y.J. Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease. Virus Res. 127 (2007) 88-94
14. Lin C.W., Lin K.H., Lyu P.C., and Chen W.J. Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper. Virus Res. 116 (2006) 106-113
15. Lin C.W., Lin K.H., Hsieh T.H., Shiu S.Y., and Li J.Y. Severe acute respiratory syndrome coronavirus 3C-like protease-induced apoptosis. FEMS Immunol. Med. Microbiol. 46 (2006) 375-380
16. Lin R.J., Liao C.L., and Lin Y.L. Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system. J. Gen. Virol. 85 (2004) 521-533
17. Lin S.S., Huang H.P., Yang J.S., Wu J.Y., Hsaim T.C., Lin C.C., Linm C.W., Kuo C.L., Gibson W., and Chung J.G. DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett. 272 (2008) 77-90
18. Lindenbach B.D., and Rice C.M. Flaviridae: the viruses and their replication. In: Knipe D.M., and Howley P.M. (Eds). Fields Virology. 4th ed. (2001), Lippincott-Raven, Philadephia 991-1041
19. Liu T.H., Liang L.C., Wang C.C., Liu H.C., and Chen W.J. The blood-brain barrier in the cerebrum is the initial site for the Japanese encephalitis virus entering the central nervous system. J. Neurovirol. 20 (2008) 1-8
20. Misra U.K., Kalita J., Goel D., and Mathur A. Clinical, radiological and neurophysiological spectrum of JEV encephalitis and other non-specific encephalitis during post-monsoon period in India. Neurol. India 51 (2003) 55-59
21. Prikhod'ko G.G., Prikhod'ko E.A., Pletnev A.G., and Cohen J.I. Langat flavivirus protease NS3 binds caspase-8 and induces apoptosis. J. Virol. 76 (2002) 5701-5710
22. Ramanathan M.P., Chambers J.A., Pankhong P., Chattergoon M., Attatippaholkun W., Dang K., Shah N., and Weiner D.B. Host cell killing by the West Nile Virus NS2B-NS3 proteolytic complex: NS3 alone is sufficient to recruit caspase-8-based apoptotic pathway. Virology 345 (2006) 56-72
23. Sánchez Y., Amrán D., Fernández C., de Blas E., and Aller P. Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK). Int. J. Cancer 123 (2008) 1205-1214
24. Shafee N., and AbuBakar S. Dengue virus type 2 NS3 protease and NS2B-NS3 protease precursor induce apoptosis. J. Gen. Virol. 84 (2003) 2191-2195
25. Singh D., McCann K.L., and Imani F. MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption. Am. J. Physiol. Lung Cell. Mol. Physiol. 293 (2007) L436-L445
26. Solomon T., Dung N.M., Kneen R., Gainsborough M., Vaughn D.W., and Khanh V.T. Japanese encephalitis. J. Neurol. Neurosurg. Psychiatry 68 (2000) 405-415
27. Su H.L., Liao C.L., and Lin Y.L. Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response. J. Virol. 76 (2002) 4162-4171
28. Sumbayev V.V., and Yasinska I.M. Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection. Scand. J. Immunol. 63 (2006) 391-400
29. Swarup V., Ghosh J., Das S., and Basu A. Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis. Neurochem. Int. 52 (2008) 1310-1321
30. Takeda K., Noguchi T., Naguro I., and Ichijo H. Apoptosis signal-regulating kinase 1 in stress and immune response. Annu. Rev. Pharmacol. Toxicol. 48 (2008) 199-225
31. Tsai T.F. Factors in the changing epidemiology of Japanese encephalitis and West Nile fever. In: Saluzzo J.F., and Dodet B. (Eds). Factors in the Emergence of Arbovirus Diseases (1997), Elselvier, Paris 179-189
32. Tsao C.H., Su H.L., Lin Y.L., Yu H.P., Kuo S.M., Shen C.I., Chen C.W., and Liao C.L. Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner. J. Gen. Virol. 89 (2008) 1930-1941
33. 2+ productions and caspase-3 activation. Mutat. Res. 601 (2006) 71-82