Gastric relaxation induced by apigenin and quercetin: Analysis of the mechanism of action

Life Sciences

Volumn 85, Issue 1-2, 2009, Pages 85-90

  Rotondo, Alessandra ^a   Serio, Rosa ^a   Mulè, Flavia ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Apigenin; Calcium antagonists; Flavonoids; Gastric tone; Quercetin; Smooth muscle

Indexed keywords

APIGENIN; CALCIUM ION; CARBACHOL; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; NIFEDIPINE; POTASSIUM ION; QUERCETIN; RYANODINE;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; MALE; MOUSE; MUSCLE CONTRACTION; MUSCLE RELAXATION; NONHUMAN; STOMACH;

ANIMALS; APIGENIN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CARBACHOL; CYCLIC AMP; CYCLIC GMP; MALE; MICE; MICE, INBRED C57BL; MUSCARINIC AGONISTS; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NIFEDIPINE; POTASSIUM CHLORIDE; QUERCETIN; STOMACH;

MURINAE;

EID: 67349241920     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.04.022     Document Type: Article

References (33)

1. Abdel-Latif AA. Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases, and contraction in smooth muscle. Experimental Biology & Medicine 226 (2001) 153-163
2. Amira S., Rotondo A., and Mulè F. Relaxant effects of flavonoids on the mouse isolated stomach: structure-activity relationships. European Journal of Pharmacology 599 (2008) 126-130
3. Ajay M., Gilani A.H., and Mustafa M.R. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sciences 74 (2003) 603-612
4. Beretz A., Briançon-Scheid F., Stierlé A., Corre G., Anton R., and Cazenave J.P. Inhibition of human platelet cyclic AMP phosphodiesterase and of platelet aggregation by a hemisynthetic flavonoid, amentoflavone hexaacetate. Biochemical Pharmacology 35 (1986) 257-262
5. Beretz A., Stierle A., Anton R., and Cazenave J.P. Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin. Biochemical Pharmacology 31 (1982) 3597-3600
6. Beretz A., Stoclet J., and Anton R. Inhibition of isolated rat aorta contraction by flavonoids. Possible correlation with cAMP-phosphodiesterase inhibition. Planta Medica 39 (1980) 236
7. Bolton T.B. Mechanism of action of transmitters and other substances on smooth muscles. Physiological Review 59 (1979) 606-718
8. Calderone V., Chericoni S., Martinelli C., Testai L., Nardi A., Morelli I., Breschi M.C., and Martinotti E. Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. Naunyn-Schmiedeberg's Archives of Pharmacology 370 (2004) 290-298
9. Capasso A., Pinto A., Sorrentino R., and Capasso F. Inhibitory effects of quercetin and other flavonoids on electrically-induced contractions of guinea pig isolated ileum. Journal of Ethnopharmacology 34 (1991) 279-281
10. Capasso A., Pinto A., Mascolo N., Autore G., and Capasso F. Reduction of agonist-induced contractions of guinea-pig isolated ileum by flavonoids. Phytotherapy Research 5 (1991) 85-87
11. Chan E.C.H., Pannangpetch P., and Woodman O.L. Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. Journal of Cardiovascular Pharmacology 35 (2000) 326-333
12. Cook N.C., and Samman S. Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary sources. Nutritional Biochemistry 7 (1996) 66-76
13. 2+ release from intracellular stores. Planta Medica 71 (2005) 962-964
14. Di Carlo G., Mascolo N., Izzo A.A., and Capasso F. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sciences 65 (1999) 337-353
15. Duarte J., Perez-Vizcaino F., Utrilla P., Jimenez J., Tamargo J., and Zarzuelo A. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. General Pharmacology 24 (1993) 857-862
16. Duarte J., Perez-Vizcaino F., Zarzuelo A., Jimenez J., and Tamargo J. Inhibitory effects of quercetin and staurosporine on phasic contractions in rat vascular smooth muscle. European Journal of Pharmacology 262 (1994) 149-156
17. Eglen R.M., Reddy H., Watson N., and Challis R.A.J. Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacological Sciences 15 (1994) 114-119
18. Gharzouli K., and Holzer P. Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein. Pharmacology 70 (2004) 5-14
19. Ghayur M.N., Khan H., and Gilani A.H. Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid. Archives of Pharmacological Research 30 (2007) 970-975
20. Hammad H.M., and Abdalla S.S. Pharmacological effects of selected flavonoids on rat isolated ileum: structure-activity relationship. General Pharmacology 28 (1997) 767-771
21. Herrera M.D., Zarzuelo A., Jiménez J., Marhuenda E., and Duarte J. Effects of flavonoids on rat aortic smooth muscle contractility: structure-activity relationships. General Pharmacology 27 (1996) 273-277
22. Iino M. Calcium-induced calcium release mechanism in guinea pig taenia caeci. Journal of General Physiology 94 (1989) 363-383
23. Ko F.N., Huang T.F., and Teng C.M. Vasodilatatory action mechanisms of apigenin from Apium graveolens in rat thoracic aorta. Biochemica and Biophysica Acta 1115 (1991) 69-74
24. Landolfi R., Nower R.L., and Steiner M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relationships. Biochemical Pharmacology 33 (1984) 1525-1530
25. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Review 52 (2000) 673-751
26. Morales M.A., and Lozoya X. Calcium-antagonist effects of quercetin on aortic smooth muscle. Planta Medica 60 (1994) 313-317
27. Morales M.A., Tortoriello J., Meckes M., Paz D., and Lozoya X. Calcium-antagonist effects of quercetin and its relation with the spasmolytic properties of Psidium guajava L. Archives of Medical Research 25 (1994) 17-21
28. Morello S., Vellecco V., Alfieri A., Mascolo N., and Cicala C. Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta. Life Sciences 78 (2006) 825-830
29. Mustafa E.H., Abu Zarga M., and Abdalla S. Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum. General Pharmacology 23 (1992) 555-560
30. Peterson J., and Dwyer J. Flavonoids: dietary occurrence and biochemical activity. Nutrition Research 18 (1998) 1995-2018
31. 2. General Pharmacology 29 (1997) 847-857
32. Ca) channel opener in vascular smooth muscle cells. British Journal of Pharmacology 149 (2006) 1013-1021
33. Williams R.J., Spencer J.P.E., and Rice-Evans C. Flavonoids: antioxidants or signalling molecules?. Free Radical Biology & Medicine 36 (2004) 838-849