The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer

British Journal of Cancer

Volumn 100, Issue 10, 2009, Pages 1659-1665

  Talieri, M ^a   Li, L ^b   Zheng, Y ^b   Alexopoulou, D K ^a   Soosaipillai, A ^c   Scorilas, A ^d   Xynopoulos, D ^a   Diamandis, E P ^c  

^a SAINT SAVVAS HOSPITAL   (Greece)

^b Fred Hutchinson Cancer Research Center   (United States)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF ATHENS   (Greece)

Author keywords

Colorectal cancer; ELISA; Kallikrein related peptidases; KLKs; Tumour markers

Indexed keywords

KALLIKREIN; KALLIKREIN 10; KALLIKREIN 11; KALLIKREIN 13; KALLIKREIN 14; KALLIKREIN 15; KALLIKREIN 5; KALLIKREIN 6; NEUROPSIN; STRATUM CORNEUM CHYMOTRYPTIC ENZYME; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CANCER TISSUE; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE MARKER; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN LOCALIZATION; SURVIVAL RATE; SURVIVAL TIME; TISSUE DISTRIBUTION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; ENDOPEPTIDASES; HUMANS; KALLIKREINS; MIDDLE AGED; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; TISSUE DISTRIBUTION; TUMOR MARKERS, BIOLOGICAL;

EID: 67349241440     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605033     Document Type: Article

References (48)

1. American Cancer Society (2005) Cancer Facts and Figures, 2005. American Cancer Society: Atlanta
2. Anwar S, Frayling IM, Scott NA, Carlson GL (2004) Systematic review of genetic influences on the prognosis of colorectal cancer. Brit J Surg 91: 1275-1291
3. Borgono CA, Diamandis EP (2004) The emerging roles of human kallikreins in cancer. Nat Rev Cancer 4: 876 - 890
4. Borgono CA, Michael IP, Show JLV, Luo L-Y, Ghosh MC, Soosaipillai A, Grass L, Katsaros D, Diamandis EP (2007) Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14. J Biol Chem 282: 2405-2422
5. Christophi GP, Isackson PJ, Blaber S, Blaber M, Rodriquez M, Scarisbrick IA (2004) Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease. J Neurochem 91: 1439-1449
6. Chung CH, Parker JS, Karaca G, Wu J, Funkhouser WK, Moore D, Butterfoss D, Xiang D, Zanation A, Yin X, Shockley WW, Weissler MC, Dressler LG, Shores CG, Yarbrough WG, Perou CM (2004) Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. Cancer Cell 5: 489 - 500
7. Coleman MP, Quaresma M, Berrino F, Lutz J-M, De Angelis R, and the CONCORD Working Group (2008) Cancer survival in five continents: a worldwide population-based study(CONCORD). Lancet Oncol 9: 730-756
8. Dasgupta S, Tripathi PK, Qin H, Bhattacharya-Chatterjee M, Valentino J, Chatterjee SK (2006) Identifiction of molecular targets for immunotherapy of patients with head and neck squamous cell carcinoma. Oral Oncol 42: 306-316
9. Dong Y, Matigian N, Harvey TJ, Samaratunga H, Hooper JD, Clements JA (2008) Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function. Biol Chem 389: 99-109
10. Dorn J, Schmitt M, Kates R, Schmalfeldt B, Kiechle M, Scorilas A, Diamandis EP, Harbeck N (2007) Primary tumor levels of human tissue kallikreins affect surgical success and survival in ovarian cancer patients. Clin Cancer Res 13: 1742-1748
11. Duffy MJ (1996) Proteases as prognostic markers of cancer. Clin Cancer Res 2: 613-618
12. Duffy MJ, van Dalen A, Haglund C, Hansson L, Klapdor R, Lamerz R, Nilsson O, Sturgeon C, Topolcan O (2003) Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines. Eur J Cancer 39: 718-727
13. Emami N, Diamandis EP (2007) Human tissue kallikreins: a road under construction. Clin Chim Acta 381: 78-84
14. Feng B, Xu WB, Zheng MH, Ma JJ, Cai Q, Zhang Y, Ji J, Lu AG, Qu Y, Li JW, Wang ML, Hu WG, Liu BY, Zhu ZG (2006) Clinical significance of human kallikrein 10 gene expression in colorectal cancer and gastric cancer. J Gastroenterol Hepatol 21: 1596-1603
15. Heagerty PJ, Lumley T, Pepe MS (2000) Time-dependent ROC curves for censored survival data and a diagnostic marker. Biometrics 56: 337-344
16. Henkhaus RS, Gerner EW, Ignatenko NA (2008a) Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells. Biol Chem 389: 757-764
17. Henkhaus R, Roy UKB, Cavallo-Medved D, Sloane BF, Gerner EW, Ignatenko NA (2008b) Caveolin-1-Mediated Expression and Secretion of kallikrein 6 in colon cancer cells. Neoplasia 10: 140-148
18. Huang W, Zhong J, Wu L-Y, Yu L-F, Tian X-l, Zhang Y-F, Li B (2007) Downregulation and CpG island hypermethylation of NES1/hK10 gene in the pathogenesis of human gastric cancer. Cancer Lett 251: 78 - 85
19. Klucky B, Mueller R, Vogt I, Teurich S, Hartenstein B, Breuhahn K, Flechtenmacher Ch, Angel P, Hess J (2007) Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion. Cancer Res 67: 8198-8206
20. Lu Y, Papagerakis P, Yamakoshi Y, Hu JCC, Bartlett JD, Simmer JP (2008) Functions of KLK4 and MMP-20 in dental enamel formation. Biol Chem 389: 695 - 700
21. Luo LY, Diamandis EP, Look MP, Soosaipillai AP, Foekens JA (2002) Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance. Br J Cancer 86: 1790-1796
22. Luo LY, Katsaros D, Scorilas A, Fracchioli S, Bellino R, van Gramberen M, de Bruijn H, Henrik A, Stenman UH, Massobrio M, van der Zee AG, Vergote I, Diamandis EP (2003) The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis. Cancer Res 63: 807-811
23. Luo LY, Rajpert De Meyts ER, Jung K, Diamandis EP (2001) Expression of the normal epithelial cell-specific I (NES1; KLK10) candidate tumor suppressor gene in normal and malignant testicular tissue. Br J Cancer 85: 220-224
24. McCracken M, Olsen M, Chen MS, Jemal A, Thun M, Cokkinides V, Deapen D, Ward E (2007) Cancer incidence, mortality, and associated risk factors British Journal of Cancer (2009) 100(10), 1659-1665 among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities. CA Cancer J Clin 57: 190-205
25. Ogawa K, Utsunomiya T, Mimori K, Tanaka F, Inoue H, Nagahara H, Mori M (2005) Clinical significance of human kallikrein gene 6 messenger RNA expression in colorectal cancer. Clin Cancer Res 11: 2889-2893
26. Oikonomopoulou K, Hansen KK, Chapman K, Vergnolle N, Diamandis EP, Hollenberg MD (2007) Kallikrein-mediated activation of PARs in inflammation and nociception. Inflamm Res 56(Suppl 3): S499-S502
27. Paliouras M, Borgono C, Diamandis E (2007) Human tissue kallikreins: the cancer bio marker family. Cancer Lett 249: 61-79
28. Pampalakis G, Diamandis E, Sotiropoulou G (2006) The epigenetic basis for the aberrant expression of kallikreins in human cancers. Biol Chem 387: 795 - 799
29. Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G (2004) Cloning and chracterization of novel isoforms of the human kallikrein 6 gene. Biochem Biophys Res Commun 320: 54-61
30. Pampalakis G, Sotiropoulou G (2007) Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer. Biochimica et Biophysica Acta 1776:22-31
31. Petraki CD, Papanastasiou PA, Karavana VN, Diamandis EP (2006) Cellular distribution of human tissue kallikreins: immunohistochemical localization. Biol Chem 387: 653-663
32. Planque Ch, Li L, Zheng Y, Soosaipillai A, Reckamp K, Chia D, Diamandis EP, Goodglick L (2008) A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. Clin Cancer Res 14: 1355-1362
33. Prezas P, Arlt MJ, Viktorov P, Soosaipillai A, Holzscheiter L, Schmitt M, Talieri M, Diamandis EP, Krüger A, Magdolen V (2006a) Overexpression of the human tissue kallikrein genes KLK4, 5, 6 and 7 increased the malignant phenotype of ovarian cancer cells. Biol Chem 387: 807-811
34. Prezas P, Scorilas A, Yfanti C, Viktorov P, Agnanti N, Diamandis EP, Talieri M (2006b) Human tissue Kallikreins 7 and 8 gene expression in intracranial tumors: a clinical study in Greece. Biol Chem 387: 613-618
35. Ramani VC, Haun RS (2008) The extracellular matrix protein fibronectin is a substrate for kallikrein 7. Biochem Biophys Res Commun 369: 1169-1173
36. Roman-Gomez J, Jimenez-Velasco A, Agerre X, Castillejo JA, Barrios M, Andreu EJ, Prosper F, Heiniger A, Torres A (2004) The normal epithelial cell-specific 1 (NES1) gene, a candidate tumor suppressor gene on chromosome 19ql3.3 - 4, is downregulated by hypermethylation in acute lymphoblastic leukemia. Leukemia 18: 362 - 365
37. Scarisbrick IA, Limbo R, Vandell AG, Keegan M, Blaber SI, Blaber M, Sneve D, Lucchinetti CF, Rodriguez M, Diamandis EP (2008) Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegenaration. Biol Chem 389: 739-746
38. Shaw JL, Diamandis EP (2007) Distribution of 15 human kallikreins in tissues and biological fluids. Clin Chem 53: 1423 - 1432
39. Shaw JL, Diamandis EP (2008) A potential role for tissue kallikrein-related peptidases in human cervico-vaginal physiology. Biol Chem 389: 681-688
40. Sidiropoulos M, Pampalakis G, Sotiropoulou G, Katsaros D, Diamandis EP (2005) Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers. Tumor Biol 26: 324-336
41. Smith Jr RS, Gao L, Chao L, Chao J (2008) Tissue kallikrein and kinin infusion promotes neovascularizatio in limb ischemia. Biol Chem 389: 725 - 730
42. Sturgeon C (2002) Practice guidelines for tumor marker use in the clinic. Clin Chem 48: 1151-1159
43. Talieri M, Diamandis EP, Gourgiotis D, Mathioudaki K, Scorilas A (2004) Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma. Thromb Haemost 91: 180-186
44. Talieri M, Prezas P, Alexopoulou DK, Mathioudaki K, Diamandis EP, Xynopoulos D, Ardavanis A, Arnogiannaki N, Scorilas A (2009) Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer. Thromb Haemost (in press)
45. Worsham MJ, Chen KM, Meduri V, Nygren AOH, Frrami A, Schouten JP, Benninger M (2006) Epigenetic events of disease progression in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 132: 668-677
46. Yousef GM, Borgono CA, Popalis C, Yacoub GM, Polymeris ME, Soosaipillai A, Diamandis EP (2004) In-silico analysis of kallikrein gene expression in pancreatic and colon cancers. Anticancer Res 24: 43-51
47. Zheng Y, Cai T, Feng Z (2006) Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers. Biometrics 62: 279-287
48. Zheng Y, Katsaros D, Shan SJ, de la Longrais IR, Porpiglia M, Scorilas A, Kim NW, Wolfert RL, Simon I, Li L, Feng Z, Diamandis EP (2007) A multiparametric panel for ovarian cancer diagnosis, prognosis, and response to chemotherapy. Clin Cancer Res 13: 6984-6992