Withanolides from Whitania aristata and their diuretic activity

Journal of Ethnopharmacology

Volumn 123, Issue 2, 2009, Pages 351-355

  Benjumea, D ^a   Martin Herrera D ^a   Abdala, S ^a   Gutierrez Luis J ^a   Quinones W ^b   Cardona, D ^b   Torres, F ^b   Echeverri, F ^b  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

Diuretic activity; Folk medicine; Medicinal plant; Solanaceae; Urinary excretion; Withania aristata

Indexed keywords

HYDROCHLOROTHIAZIDE; PLANT EXTRACT; POTASSIUM ION; SODIUM CHLORIDE; SODIUM ION; UNCLASSIFIED DRUG; WHITANIA ARISTATA EXTRACT; WITHAFERIN A; WITHANOLIDE; WITHARISTATIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIURESIS; DIURETIC ACTIVITY; DRUG ISOLATION; FEMALE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; POTASSIUM EXCRETION; RAT; SODIUM EXCRETION; URINE; WHITANIA ARISTATA;

ADMINISTRATION, ORAL; ANIMALS; DIURESIS; DIURETICS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROCHLOROTHIAZIDE; MALE; MEDICINE, TRADITIONAL; MICE; PLANT EXTRACTS; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SPAIN; WITHANIA; WITHANOLIDES;

ANIMALIA; SOLANACEAE; WITHANIA;

EID: 67349233534     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.12.014     Document Type: Article

References (21)

1. Abe F., Nagafuji S., Okawa M., and Kinjo J. Trypanocidal constituents in plants 6.1. Minor withanolides from the aerial parts of Physalis angulata. Chemical & Pharmaceutical Bulletin 54 (2006) 1226-1228
2. Bani S., Gautam M., Sheikh F.A., Khan B., Satti N.D., Suri K.A., Qazi G.N., and Patwardhan B. Selective Th1 up-regulating activity of Withania somnifera aqueous extract in an experimental system using flow cytometry. Journal of Ethnopharmacology 107 (2006) 107-115
3. Cardona D., Quiñones W., Torres T., Robledo S., Vélez H.D., Cruz V., Notario R., and Echeverri F. Leishmanicidal activity of withajardins and acnistins. An experimental and computational study. Tetrahedron 62 (2006) 6822-6829
4. Choudhary M.I., Nawaz S.A., Haq Z.U., and Lodhi M.A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Biochemical and Biophysical Research Communications 334 (2005) 276-287
5. Darias V., Bravo L., Barquín E., Martín-Herrera D., and Fraile C. Contribution to the ethnopharmacological study of the Canary Island. Journal of Ethnopharmacology 15 (1986) 169-193
6. Darias V., Martín-Herrera D., Abdala S., and De la Fuente D. Plants used in urinary pathologies in the Canary Islands. Pharmaceutical Biology 39 (2001) 170-180
7. González A., Bretón Funes J.L., and Trujillo J.M. Withanolides of Withania aristata and Withania frutescens. Anales de Química 68 (1972) 107-108
8. González A., Bretón Funes J.L., and Trujillo J.M. Withania steroids. II. Five steroidal lactones of Withania aristata. Anales de Química 70 (1974) 64-68
9. Gottlieb H.E., and Kirson I. Carbon-13 NMR spectroscopy of the withanolides and other highly oxygenated C28 steroids. Organic Magnetic Resonance 16 (1981) 20-25
10. Ichikawa H., Takada Y., Shishodia S., Jayaprakasam B., Nair M.G., and Aggarwal B.B. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression. Molecular Cancer Therapeutics 5 (2006) 1434-1445
11. Jayaprakasam B., Strasburg G.A., and Nair M.G. Potent lipid peroxidation inhibitors from Withania somnifera fruits. Tetrahedron 60 (2004) 3109-3121
12. Jayaprakasam B., Zhang Y., Seeram N.P., and Nair M.G. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. Life Sciences 74 (2003) 125-132
13. Kau S.T., Keddi J.R., and Andrews D. A method for screening diuretic agents in rats. Journal Pharmacological Methods 11 (1984) 67-75
14. Khanna D., Sethi G., Ahn K.S., Pandey M.K., Kunnumakkara A.B., Sung B., Aggarwal A., and Aggarwal B.B. Natural products as a gold mine for arthritis treatment. Current Opinion on Pharmacology 7 (2007) 344-351
15. Malik F., Singh J., Khajuria A., Suri K.A., Satti N.K., Singh S., Kaul M.K., Kumar A., Bhatia A., and Qazi G.N. A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by upregulation of Th1-dominant polarization in BALB/c mice. Life Sciences 80 (2007) 1525-1538
16. Martín-Herrera D., Abdala S., Benjumea D., and Pérez-Paz P. Diuretic activity of Withania aristata: an endemic Canary Island species. Journal of Ethnopharmacology 113 (2007) 487-491
17. Martín-Herrera D., Abdala S., Benjumea D., and Gutiérrez-Luis J. Diuretic activity of some Withania aristata Ait. fractions. Journal of Ethnopharmacology 117 (2008) 496-499
18. Muregi F.W., Ishih A., Miyase T., Suzuki T., Kino H., Amano T., Mkoji G.M., and Terada M. Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice. Journal of Ethnopharmacology 111 (2007) 190-195
19. Pérez-Paz, P., Hernández Padrón, C., 1999. Plantas Medicinales o Útiles en la Flora Canaria. Aplicaciones Populares. Ed. Francisco Lemus. La Laguna, p. 386.
20. Valera, M.A., Santos G.A., 2002. Investigaciones Fitoquímicas en Plantas Canarias. Ed. Centro de Estudios Fundación Ramón Areces. Madrid. p. 48 and 197.
21. Veleiro A.S., Oberti J.C., and Burton G. Chemistry and bioactivity of withanolides from South American Solanaceae. Studies in Natural Products Chemistry 32 (2005) 1019-1052