Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties

Biochemical and Biophysical Research Communications

Volumn 334, Issue 1, 2005, Pages 276-287

  Choudhary, M Iqbal ^a   Nawaz, Sarfraz Ahmad ^a   Zaheer Ul Haq, ^a   Lodhi, M Arif ^a   Ghayur, M Nabeel ^b   Jalil, Saima ^a   Riaz, Naheed ^a   Yousuf, Sammer ^a   Malik, Abdul ^a   Gilani, Anwarul Hassan ^b   Atta Ur Rahman, ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

Acetylcholinesterase; Ajuga bracteosa; Butyrylcholinesterase; Calcium antagonist; Enzyme inhibition; Molecular docking studies; Withania somnifera; Withanolides

Indexed keywords

CALCIUM ANTAGONIST; CALCIUM ION; CHOLINESTERASE INHIBITOR; LIGAND; POTASSIUM ION; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG; WITHANOLIDE; WITHANOLIDE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM ANTAGONISM; CATALYSIS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SAFETY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IC 50; INTERMETHOD COMPARISON; INTESTINE CONTRACTION; JEJUNUM; LINEAR SYSTEM; MALE; MOLECULAR INTERACTION; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RABBIT; SPASMOLYSIS; WITHANIA SOMNIFERA;

ACETYLCHOLINESTERASE; ANIMALS; CALCIUM; CALCIUM SIGNALING; CELL SURVIVAL; CELLS, CULTURED; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ERGOSTEROL; HUMANS; JEJUNUM; LETHAL DOSE 50; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEUTROPHILS; RABBITS; WITHANIA;

AJUGA; ORYCTOLAGUS CUNICULUS; WITHANIA SOMNIFERA;

EID: 22144444946     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.06.086     Document Type: Article

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