Synthesis of bioactive spiro-2-[3'-(2'-phenyl)-3H-indolyl]-1-aryl-3- phenylaziridines and SAR studies on their antimicrobial behavior

Medicinal Chemistry Research

Volumn 18, Issue 5, 2009, Pages 383-395

  Sharma, Pratibha ^a   Kumar, Ashok ^a   Sahu, Vinita ^a   Upadhyay, Siya ^a   Singh, Jitendra ^a  

^a DEVI AHILYA UNIVERSITY   (India)

Author keywords

Antimicrobial; Aziridine; Biological activity; SAR

Indexed keywords

ANTIINFECTIVE AGENT; AZIRIDINE DERIVATIVE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (2'' CARBOXY)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (2'' CHLORO)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (2'' ETHOXY)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (2'' HYDROXY)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (2'' METHOXY)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (2'' NITRO)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (3'' CHLORO)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (3'' ETHOXY)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (3'' HYDROXY)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (3'' METHOXY)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (3'' METHYL)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (3'' NITRO)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (4'' CHLORO)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (4'' HYDROXY)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1 (4'' NITRO)PHENYL 3 PHENYL AZIRIDINE; SPIRO 2 [3' (2' PHENYL) 3H INDOLYL] 1,3 DIPHENYL AZIRIDINE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FINITE ELEMENT ANALYSIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INFRARED SPECTROSCOPY; LD 50; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REFRACTION INDEX; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

EID: 67349226348     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-008-9135-y     Document Type: Article

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