Synthesis and in vitro antimicrobial activities of 2-hydroxy-6-methyl-7- (arylamino)-1,7-dihydropurin-8-ones

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 12, 2004, Pages 3135-3139

  Sharma, Pratibha ^a   Sharma, Shikha ^a   Rane, Nilesh ^a  

^a DEVI AHILYA UNIVERSITY   (India)

Author keywords

2 Hydroxy 6 methyl 7 (arylamino) 1,7 dihydropurin 8 ones; Hammett substituent constant ( ); Molecular refractive index parameters (MR)

Indexed keywords

3 OXO 2 (HYDRAZONO)BUTYRIC ACID ETHYL ESTER; ACETAMIDE DERIVATIVE; ANTIINFECTIVE AGENT; DIOXANE; ESTER DERIVATIVE; FORMAMIDE; N (5 ACETYL 4 ETHOXY 2 OXO 2,5 DIHYDROIMIDAZOL 1 YL) N ACETAMIDE; PURINE DERIVATIVE; TRIETHYLAMINE; UNCLASSIFIED DRUG; UREA;

ACETYLATION; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REFRACTION INDEX; SCREENING; SPECTROSCOPY;

AMINATION; ANTI-BACTERIAL AGENTS; HYDROXYLATION; METHYLATION; MOLECULAR STRUCTURE; PURINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RHIZOBIUM;

NEGIBACTERIA; POSIBACTERIA;

EID: 2542431287     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.007     Document Type: Article

References (31)

1. Kim H.O., Park Y.H., Moon H.R., Jeong L.S. Bioorg. Med. Chem. Lett. 12:2002;2403
2. Fuji T., Itaya T., Ogawa K. Heterocycles. 44:1997;573
3. Biagi G., Costantini A., Constantino L., Giorgi I., Livi O., Pecorari P., Rinaldi Scartoni V. J. Med. Chem. 4:1996;609
4. Yu H.W., Zhang L.R., Zhou J.C., Ma L.T., Zhang L.H. Bioorg. Med. Chem. Lett. 4:1996;609
5. Legraerend M., Ludwig O., Bisagni E., Leclrec S., Meijer L., Giocanti N., Sadri R., Favaudon V. Bioorg. Med. Chem. Lett. 7:1999;1281
6. Seley K.L., Zanuszcyzy K.P., Hagos A., Zhang L., Dransfield D.T. J. Med. Chem. 43:2003;4877
7. Bakkestuen A.K., Gundersen L.L., Langli G., Liu F., Nolsoe J.M. J. Bioorg. Med. Chem. Lett. 10:2000;1207
8. Gundersen L.L., Nissen-Meyer J., Spilsberg B. J. Med. Chem. 45:2002;1383
9. Cocuzza A.J., Chidester D.R., Culp S., Fitzgerald L., Gilligan P. Bioorg. Med. Chem. Lett. 9:1999;1063
10. Kelley J.L., Linn J.A., Selway J.W.T. J. Med. Chem. 34:1991;157
11. Nagamatsu T., Fujita T., Endo K. J. Chem. Soc., Perkin Trans. 1. 2000;33
12. DeSarro A., DeSarro G., Chimrri A., Grasso S. Gen. Pharmacol. 25:1994;1027
13. Jacobso K.A., Daly J.W., Manganiello V. Purines in Cellular Signaling: Targets for New Drugs. 1990;Springer, New York
14. Brun V., Legraverend M., Grierson D.S. Tetrahedron. 58:2002;7911
15. Austin R.E., Okonya J.F., Bond D.R., Al-Obedi F. Tetrahedron Lett. 43:2002;6169
16. Shawali A.S., Mosselhi M.A.N., Tawik N.M. J. Org. Chem. 66:2001;4055
17. Hirota K., Monguchi Y., Sajiki H., Kiatde Y. Synlett. 6:1997;697
18. Bush K., Macielag M. Curr. Opin. Chem. Biol. 4:2000;433
19. Sharma P., Kumar A., Pandey P. Phosphorus, Sulphur and Silicon. 178:2003;583
20. Sharma P., Kumar A., Sharma S. Ind. J. Chem. 43B:2004;385
21. Sharma P., Kumar A., Mandloi A. Synth. Commun. 373:2003;33
22. Jain R., Pandey P. Bull. Electrochem. 2:1987;177
23. Furniss, B. S.; Hannaford, A. J.; Roger, V.; Smith, P. W. G.; Tatchell, A. K. In Vogel's Textbook of Organic Chemistry (Longmann) 1984
24. Rapper R.P. The Actinomycates. 88:1901;12
25. Kumar A., Sharma P., Nigam A., Indapurkar P. Ind. J. Chem. 36B:1997;445
26. Dreisbach R.R. Physical Properties of Chemical Compound. 1961;Am. Chem. Soc, Washington, DC
27. Skagerberg B., Bonelli D., Clementi S., Cruciani G., Ebert C. Quant. Struct. Act. Relat. 8:1989;32
28. 5: C, 56.03; H, 4.28; N, 27.24. Found: C, 55.95; H, 4.20; N, 27.21
29. 5Cl: C, 49.40; H, 3.43; N, 24.01. Found: C, 49.31; H, 3.33; N, 23.90
30. 6: C, 47.68; H, 3.31; N, 27.81. Found: C, 47.60; H, 3.25; N, 27.73
31. 5: C, 57.56; H, 4.80; N, 25.83. Found: C, 57.48; H, 4.75; N, 25.70