메뉴 건너뛰기




Volumn 41, Issue 8-9, 2009, Pages 1731-1738

Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling

Author keywords

Pancreatic neoplasms; Proliferation and migration; Small interfering RNA; Urokinase plasminogen activator receptor

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PLASMINOGEN ACTIVATOR INHIBITOR 2; SMALL INTERFERING RNA; UROKINASE; UROKINASE RECEPTOR;

EID: 67349218408     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.03.004     Document Type: Article
Times cited : (33)

References (41)
  • 1
    • 52049093658 scopus 로고    scopus 로고
    • The urokinase receptor (u-PAR)-a link between tumor cell dormancy and minimal residual disease in bone marrow?
    • Allgayer H., and guirre-Ghiso J.A. The urokinase receptor (u-PAR)-a link between tumor cell dormancy and minimal residual disease in bone marrow?. APMIS 116 (2008) 602-614
    • (2008) APMIS , vol.116 , pp. 602-614
    • Allgayer, H.1    guirre-Ghiso, J.A.2
  • 2
    • 0030788411 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator system in cancer metastasis: a review
    • Andreasen P.A., Kjoller L., Christensen L., and Duffy M.J. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 72 (1997) 1-22
    • (1997) Int J Cancer , vol.72 , pp. 1-22
    • Andreasen, P.A.1    Kjoller, L.2    Christensen, L.3    Duffy, M.J.4
  • 3
    • 24744449559 scopus 로고    scopus 로고
    • Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice
    • Bauer T.W., Liu W., Fan F., Camp E.R., Yang A., Somcio R.J., et al. Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice. Cancer Res 65 (2005) 7775-7781
    • (2005) Cancer Res , vol.65 , pp. 7775-7781
    • Bauer, T.W.1    Liu, W.2    Fan, F.3    Camp, E.R.4    Yang, A.5    Somcio, R.J.6
  • 4
    • 34347370458 scopus 로고    scopus 로고
    • MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells
    • Bessard A., Fremin C., Ezan F., Coutant A., and Baffet G. MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells. J Cell Physiol 212 (2007) 526-536
    • (2007) J Cell Physiol , vol.212 , pp. 526-536
    • Bessard, A.1    Fremin, C.2    Ezan, F.3    Coutant, A.4    Baffet, G.5
  • 6
    • 0032947058 scopus 로고    scopus 로고
    • MAP kinase pathways
    • Cobb M.H. MAP kinase pathways. Prog Biophys Mol Biol 71 (1999) 479-500
    • (1999) Prog Biophys Mol Biol , vol.71 , pp. 479-500
    • Cobb, M.H.1
  • 7
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley S., Paterson H., Kemp P., and Marshall C.J. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77 (1994) 841-852
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 9
    • 43249124467 scopus 로고    scopus 로고
    • Prostate cancer cell-derived urokinase-type plasminogen activator contributes to intraosseous tumor growth and bone turnover
    • Dong Z., Saliganan A.D., Meng H., Nabha S.M., Sabbota A.L., Sheng S., et al. Prostate cancer cell-derived urokinase-type plasminogen activator contributes to intraosseous tumor growth and bone turnover. Neoplasia 10 (2008) 439-449
    • (2008) Neoplasia , vol.10 , pp. 439-449
    • Dong, Z.1    Saliganan, A.D.2    Meng, H.3    Nabha, S.M.4    Sabbota, A.L.5    Sheng, S.6
  • 10
    • 0347917028 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system: role in malignancy
    • Duffy M.J. The urokinase plasminogen activator system: role in malignancy. Curr Pharm Des 10 (2004) 39-49
    • (2004) Curr Pharm Des , vol.10 , pp. 39-49
    • Duffy, M.J.1
  • 11
    • 0025336879 scopus 로고
    • The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes
    • Estreicher A., Muhlhauser J., Carpentier J.L., Orci L., and Vassalli J.D. The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol 111 (1990) 783-792
    • (1990) J Cell Biol , vol.111 , pp. 783-792
    • Estreicher, A.1    Muhlhauser, J.2    Carpentier, J.L.3    Orci, L.4    Vassalli, J.D.5
  • 12
    • 0033968403 scopus 로고    scopus 로고
    • The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients
    • Foekens J.A., Peters H.A., Look M.P., Portengen H., Schmitt M., Kramer M.D., et al. The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients. Cancer Res 60 (2000) 636-643
    • (2000) Cancer Res , vol.60 , pp. 636-643
    • Foekens, J.A.1    Peters, H.A.2    Look, M.P.3    Portengen, H.4    Schmitt, M.5    Kramer, M.D.6
  • 13
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: diversity and escape mechanisms
    • Friedl P., and Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3 (2003) 362-374
    • (2003) Nat Rev Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 14
    • 33749032836 scopus 로고    scopus 로고
    • Prognostic significance of nuclear factor-kappaB p105/p50 in human melanoma and its role in cell migration
    • Gao K., Dai D.L., Martinka M., and Li G. Prognostic significance of nuclear factor-kappaB p105/p50 in human melanoma and its role in cell migration. Cancer Res 66 (2006) 8382-8388
    • (2006) Cancer Res , vol.66 , pp. 8382-8388
    • Gao, K.1    Dai, D.L.2    Martinka, M.3    Li, G.4
  • 15
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • guirre-Ghiso J.A., Kovalski K., and Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 147 (1999) 89-104
    • (1999) J Cell Biol , vol.147 , pp. 89-104
    • guirre-Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 16
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • guirre-Ghiso J.A. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 7 (2007) 834-846
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • guirre-Ghiso, J.A.1
  • 17
    • 0037379794 scopus 로고    scopus 로고
    • ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)
    • guirre-Ghiso J.A., Estrada Y., Liu D., and Ossowski L. ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res 63 (2003) 1684-1695
    • (2003) Cancer Res , vol.63 , pp. 1684-1695
    • guirre-Ghiso, J.A.1    Estrada, Y.2    Liu, D.3    Ossowski, L.4
  • 18
    • 0035172910 scopus 로고    scopus 로고
    • Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo
    • guirre-Ghiso J.A., Liu D., Mignatti A., Kovalski K., and Ossowski L. Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell 12 (2001) 863-879
    • (2001) Mol Biol Cell , vol.12 , pp. 863-879
    • guirre-Ghiso, J.A.1    Liu, D.2    Mignatti, A.3    Kovalski, K.4    Ossowski, L.5
  • 19
    • 5644222639 scopus 로고    scopus 로고
    • Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth
    • guirre-Ghiso J.A., Ossowski L., and Rosenbaum S.K. Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res 64 (2004) 7336-7345
    • (2004) Cancer Res , vol.64 , pp. 7336-7345
    • guirre-Ghiso, J.A.1    Ossowski, L.2    Rosenbaum, S.K.3
  • 20
    • 0028331139 scopus 로고
    • The urokinase receptor is required for human monocyte chemotaxis in vitro
    • Gyetko M.R., Todd III R.F., Wilkinson C.C., and Sitrin R.G. The urokinase receptor is required for human monocyte chemotaxis in vitro. J Clin Invest 93 (1994) 1380-1387
    • (1994) J Clin Invest , vol.93 , pp. 1380-1387
    • Gyetko, M.R.1    Todd III, R.F.2    Wilkinson, C.C.3    Sitrin, R.G.4
  • 21
    • 0033590636 scopus 로고    scopus 로고
    • Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
    • Hoshino R., Chatani Y., Yamori T., Tsuruo T., Oka H., Yoshida O., et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 18 (1999) 813-822
    • (1999) Oncogene , vol.18 , pp. 813-822
    • Hoshino, R.1    Chatani, Y.2    Yamori, T.3    Tsuruo, T.4    Oka, H.5    Yoshida, O.6
  • 22
    • 0028261732 scopus 로고
    • Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes
    • Hotz M.A., Gong J., Traganos F., and Darzynkiewicz Z. Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry 15 (1994) 237-244
    • (1994) Cytometry , vol.15 , pp. 237-244
    • Hotz, M.A.1    Gong, J.2    Traganos, F.3    Darzynkiewicz, Z.4
  • 24
    • 0032522751 scopus 로고    scopus 로고
    • Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction
    • Konakova M., Hucho F., and Schleuning W.D. Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction. Eur J Biochem 253 (1998) 421-429
    • (1998) Eur J Biochem , vol.253 , pp. 421-429
    • Konakova, M.1    Hucho, F.2    Schleuning, W.D.3
  • 25
    • 48149112465 scopus 로고    scopus 로고
    • Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor
    • Kotzsch M., Sieuwerts A.M., Grosser M., Meye A., Fuessel S., Meijer-van Gelder M.E., et al. Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor. Breast Cancer Res Treat 111 (2008) 229-240
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 229-240
    • Kotzsch, M.1    Sieuwerts, A.M.2    Grosser, M.3    Meye, A.4    Fuessel, S.5    Meijer-van Gelder, M.E.6
  • 26
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
    • Liu D., Aguirre G.J., Estrada Y., and Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 1 (2002) 445-457
    • (2002) Cancer Cell , vol.1 , pp. 445-457
    • Liu, D.1    Aguirre, G.J.2    Estrada, Y.3    Ossowski, L.4
  • 27
    • 0037116616 scopus 로고    scopus 로고
    • Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients
    • Look M.P., van Putten W.L., Duffy M.J., Harbeck N., Christensen I.J., Thomssen C., et al. Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients. J Natl Cancer Inst 94 (2002) 116-128
    • (2002) J Natl Cancer Inst , vol.94 , pp. 116-128
    • Look, M.P.1    van Putten, W.L.2    Duffy, M.J.3    Harbeck, N.4    Christensen, I.J.5    Thomssen, C.6
  • 28
    • 0034782160 scopus 로고    scopus 로고
    • Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells
    • Ma Z., Webb D.J., Jo M., and Gonias S.L. Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells. J Cell Sci 114 (2001) 3387-3396
    • (2001) J Cell Sci , vol.114 , pp. 3387-3396
    • Ma, Z.1    Webb, D.J.2    Jo, M.3    Gonias, S.L.4
  • 30
    • 16844385164 scopus 로고    scopus 로고
    • The urokinase receptor and the regulation of cell proliferation
    • Mazzieri R., and Blasi F. The urokinase receptor and the regulation of cell proliferation. Thromb Haemost 93 (2005) 641-646
    • (2005) Thromb Haemost , vol.93 , pp. 641-646
    • Mazzieri, R.1    Blasi, F.2
  • 31
    • 14844304638 scopus 로고    scopus 로고
    • Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction
    • Nielsen A., Scarlett C.J., Samra J.S., Gill A., Li Y., Allen B.J., et al. Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction. J Gastroenterol Hepatol 20 (2005) 256-263
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 256-263
    • Nielsen, A.1    Scarlett, C.J.2    Samra, J.S.3    Gill, A.4    Li, Y.5    Allen, B.J.6
  • 32
    • 0020621220 scopus 로고
    • Changes in malignant phenotype of a human carcinoma conditioned by growth environment
    • Ossowski L., and Reich E. Changes in malignant phenotype of a human carcinoma conditioned by growth environment. Cell 33 (1983) 323-333
    • (1983) Cell , vol.33 , pp. 323-333
    • Ossowski, L.1    Reich, E.2
  • 33
    • 32544434362 scopus 로고    scopus 로고
    • Pre-clinical study of 213Bi labeled PAI2 for the control of micrometastatic pancreatic cancer
    • Qu C.F., Song E.Y., Li Y., Rizvi S.M., Raja C., Smith R., et al. Pre-clinical study of 213Bi labeled PAI2 for the control of micrometastatic pancreatic cancer. Clin Exp Metastasis 22 (2005) 575-586
    • (2005) Clin Exp Metastasis , vol.22 , pp. 575-586
    • Qu, C.F.1    Song, E.Y.2    Li, Y.3    Rizvi, S.M.4    Raja, C.5    Smith, R.6
  • 35
    • 33748626267 scopus 로고    scopus 로고
    • Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis
    • Sehgal I., Foster T.P., and Francis J. Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis. Cancer Cell Int 6 (2006) 21
    • (2006) Cancer Cell Int , vol.6 , pp. 21
    • Sehgal, I.1    Foster, T.P.2    Francis, J.3
  • 36
    • 33847686021 scopus 로고    scopus 로고
    • High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma
    • Smith R., Xue A., Gill A., Scarlett C., Saxby A., Clarkson A., et al. High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma. World J Surg 31 (2007) 493-502
    • (2007) World J Surg , vol.31 , pp. 493-502
    • Smith, R.1    Xue, A.2    Gill, A.3    Scarlett, C.4    Saxby, A.5    Clarkson, A.6
  • 37
    • 0042349229 scopus 로고    scopus 로고
    • ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
    • Vial E., Sahai E., and Marshall C.J. ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell 4 (2003) 67-79
    • (2003) Cancer Cell , vol.4 , pp. 67-79
    • Vial, E.1    Sahai, E.2    Marshall, C.J.3
  • 38
    • 45549094584 scopus 로고    scopus 로고
    • Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma
    • Xue A., Scarlett C.J., Jackson C.J., Allen B.J., and Smith R.C. Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma. Pancreas 36 (2008) 160-167
    • (2008) Pancreas , vol.36 , pp. 160-167
    • Xue, A.1    Scarlett, C.J.2    Jackson, C.J.3    Allen, B.J.4    Smith, R.C.5
  • 39
    • 34250372944 scopus 로고    scopus 로고
    • Protein C is an autocrine growth factor for human skin keratinocytes
    • Xue M., Campbell D., and Jackson C.J. Protein C is an autocrine growth factor for human skin keratinocytes. J Biol Chem 282 (2007) 13610-13616
    • (2007) J Biol Chem , vol.282 , pp. 13610-13616
    • Xue, M.1    Campbell, D.2    Jackson, C.J.3
  • 40
    • 33748053952 scopus 로고    scopus 로고
    • Plasticity in urokinase-type plasminogen activator receptor (uPAR) display in colon cancer yields metastable subpopulations oscillating in cell surface uPAR density-implications in tumor progression
    • Yang L., Avila H., Wang H., Trevino J., Gallick G.E., Kitadai Y., et al. Plasticity in urokinase-type plasminogen activator receptor (uPAR) display in colon cancer yields metastable subpopulations oscillating in cell surface uPAR density-implications in tumor progression. Cancer Res 66 (2006) 7957-7967
    • (2006) Cancer Res , vol.66 , pp. 7957-7967
    • Yang, L.1    Avila, H.2    Wang, H.3    Trevino, J.4    Gallick, G.E.5    Kitadai, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.