Hyperinsulinemia is common in family members of women with polycystic ovary syndrome

Fertility and Sterility

Volumn 66, Issue 6, 1996, Pages 942-947

  Norman, R J ^a   Masters, S ^a   Hague, W ^a  

^a QUEEN ELIZABETH HOSPITAL   (Australia)

Author keywords

familial incidence; insulin; Polycystic ovary syndrome

Indexed keywords

INSULIN; LIPID; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ALOPECIA; ARTICLE; ECHOGRAPHY; FAMILY; FEMALE; GENETIC MARKER; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PARENT; PRIORITY JOURNAL; SIBLING;

EID: 0030473142     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0015-0282(16)58687-7     Document Type: Article

References (23)

1. J.L. Simpson Elucidating the genetics of polycystic ovary syndrome A. Dunaif J.R. Givens F.P. Haseltine G.R. Merrian Polycystic ovary syndrome. Current issues in endocrinology and metabolism 1992 Blackwell Boston 59 70
2. R.S. Legro The genetics of polycystic ovary syndrome Am J Med 98 Suppl 1A 1995 95 165
3. H.E. Cooper W.N. Spellacy K.A. Prem W.D. Cohen Hereditary factors in Stein-Leventhal syndrome Am J Obstet Gynecol 100 1968 371 387
4. A.H. Carey K.L. Chan F. Short D. White R. Williamson S. Franks Evidence for a single gene causing polycystic ovaries and male pattern baldness Clin Endocrinol (Oxf) 38 1993 653 659
5. J.R. Givens Familial polycystic ovarian disease Endocrinol Metab Clin North Am 17 1988 1 17
6. W.M. Hague J. Adams S.T. Reeder T.E. Peto H.S. Jacobs Familial polycystic ovaries: a genetic disease? Clin Endocrinol (Oxf) 29 1988 593 605
7. R.J. Norman S.C. Masters W.M. Hague C. Beng P. Pannall J.X. Wang Metabolic approaches to the subclassification of polycystic ovary syndrome Fertil Steril 63 1995 329 335
8. J.K. Zawadzki A. Dunaif Diagnostic criteria for polycystic ovary syndrome: towards a rational approach A. Dunaif J.R. Givens F.P. Haseltine G.R. Merriam Polycystic ovary syndrome. Current issues in endocrinology and metabolism 1992 Blackwell Boston 377 384
9. A. Dunaif Hyperandrogenie anovulation (PCOS): a unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus Am J Med 98 Supp lA 1995 335 395
10. R.L. Barbieri S. Smith K.J. Ryan The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism Fertil Steril 50 1988 197 212
11. S. Robinson S.P. Chan S. Spacey V. Anyaoku D.G. Johnston S. Franks Postprandial thermogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance Clin Endocrinol (Oxf) 36 1992 537 543
12. S. Franks Polycystic ovary syndrome N Engl J Med 333 1995 853 861
13. D. Meirow O. Yossepowitch A. Rosier A. Brzezinski J.G. Schenker N. Laufer Insulin resistant and non-resistant polycystic ovary syndrome represent two clinical and endocrinology subgroups Hum Reprod 10 1995 1951 1956
14. J. Adams D.W. Polson S. Franks Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism Br Med J 293 1986 355 359
15. A.M. Clark W. Ledger C. Galletly L. Tomlinson F. Blaney R.J. Norman Weight loss results in significant improvement in pregnancy and ovulation rates in infertile, obese women Hum Reprod 10 1995 2705 2712
16. F.S. Facchini C.B. Hollenbeck J. Jappesen Y.-D.I. Chen G.M. Reaven Insulin resistance and cigarette smoking Lancet 339 1992 1128 1130
17. D.W. Polson J. Adams J. Wadsworth S. Franks Polycystic ovaries—a common finding in normal women Lancet 1 1988 870 872
18. R.N. Clayton V. Ogden J. Hodgkinson L. Worswick D.A. Rodin S. Dyer How common are polycystic ovaries in normal women and what is their significance for the fertility of the population? Clin Endocrinol (Oxf) 37 1992 127 134
19. A. Laws M.L. Stefanick G.M. Reaven Insulin resistance and hypertriglyceridemia in non diabetic relatives of patients with non insulin-dependent diabetes mellitus J Clin Endocrinol Metab 69 1989 343 347
20. E. Dahlgren S. Johansson G. Lindstedt F. Knutsson A. Odén P.O. Janson Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long term follow-up focussing on natural history and circulating hormones Fertil Steril 57 1992 505 513
21. A. Dunaif K.R. Segal W. Futterweit A. Dobransky Profound peripheral insulin resistance independent of obesity in polycystic ovary syndrome Diabetes 38 1989 1165 1174
22. G.S. Conway P.M. Clark D. Wong Hyperinsulinaemia in the polycystic ovary syndrome confirmed with a specific immunoradiometric assay for insulin Clin Endocrinol (Oxf) 38 1993 219 222
23. A. Dunaif J. Xia C.B. Book E. Schenker Z. Tang Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle J Clin Invest 96 1995 801 810