Vitamin A supplementation at pharmacological doses induces nitrosative stress on the hypothalamus of adult Wistar rats

Chemico-Biological Interactions

Volumn 180, Issue 3, 2009, Pages 407-413

  De Oliveira, Marcos Roberto ^a   Oliveira, Max William Soares ^a   Da Rocha, Ricardo Fagundes ^a   Moreira, José Cláudio Fonseca ^a  

^a Instituto de Ciencias Biologicas e da Saude Pontifical Catholic University of Minas Gerais   (Brazil)

Author keywords

Mitochondrial electron transfer chain; Nitrosative stress; Rat hypothalamus; Redox environment; Vitamin A

Indexed keywords

3 NITROTYROSINE; ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA SYNUCLEIN; CASPASE 3; CATALASE; CYTOCHROME C OXIDASE; DOPAMINE 2 RECEPTOR; FREE RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RETINOL PALMITATE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; ELECTRON TRANSPORT; ENCEPHALITIS; ENZYME ACTIVITY; EVENING DOSAGE; HYPOTHALAMUS; MALE; NERVE CELL NECROSIS; NITROSATIVE STRESS; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; RAT; TREATMENT DURATION; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ALPHA-SYNUCLEIN; ANIMALS; BRAIN; CASPASE 3; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; HYPOTHALAMUS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE; VITAMIN A;

MAMMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 67349201659     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.02.006     Document Type: Article

References (42)

1. Ross S.A., McCaferry P.J., Dräger U.C., and De Luca L.M. Retinoids in embryonal development. Physiol. Rev. 80 (2000) 1021-1054
2. Lane M.A., and Bailey S.J. Role of retinoids signaling in the adult brain. Prog. Neurobiol. 75 (2005) 275-293
3. McCaferry P., Zhang J., and Crandall J.E. Retinoic acid signaling and function in the adult hippocampus. J. Neurobiol. 66 (2005) 780-791
4. Maden M., Gale E., Kostetskii I., and Zile M. Vitamin A-deficient quail embryos have half a hindbrain and other neural defects. Curr. Biol. 6 (1996) 417-426
5. Cocco S., Diaz G., Stancampiano R., Diana A., Carta M., Curreli R., Sarais L., and Fadda F. Vitamin A deficiency produces spatial learning and memory impairment in rats. Neuroscience 115 (2002) 475-482
6. Etchamendy N., Enderlin V., Marighetto A., Pallet V., Higueret P., and Jaffard R. Vitamin A deficiency and relational memory deficit in adult mice: relationships with changes in brain retinoid signaling. Behav. Brain Res. 145 (2003) 37-49
7. Cohlan S.Q. Excessive intakes of vitamin A as a cause of congenital anomalies in the rat. Science 117 (1953) 535-536
8. Restak R.M. Pseudotumor cerebri, psychosis, and hypervitaminosis A. J. Nerv. Ment. Dis. 155 (1972) 72-75
9. Allen L.H., and Haskell M. Estimating the potential for vitamin A toxicity in women and young children. J. Nutr. 132 (2002) 2907S-2919S
10. Myhre A.M., Carlsen M.H., Bohn S.K., Wold H.L., Laake P., and Blomhoff R. Water-miscible, emulsified, and solid forms of retinol supplements are more toxic than oil-based preparations. Am. J. Clin. Nutr. 78 (2003) 1152-1159
11. Paydas S., Sahin B., Zorludemir S., and Hazar B. All trans retinoic acid as possible cause of necrotizing vasculitis. Leuk. Res. 22 (1998) 655-657
12. Fenaux P., Chomienne C., and Degos L. Treatment of acute promyelocytic leukaemia. Best Pract. Res. Clin. Haematol. 14 (2001) 153-174
13. De Oliveira M.R., and Moreira J.C.F. Acute and chronic vitamin A supplementation at therapeutic doses induces oxidative stress to submitochondrial particles isolated from cerebral cortex and cerebellum of adult rats. Toxicol. Lett. 173 (2007) 145-150
14. De Oliveira M.R., Pasquali M.A.B., Silvestrin R.B., Mello e Souza T., and Moreira J.C.F. Vitamin A supplementation induces a pro-oxidative state in the striatum and impairs locomotory and exploratory activity of adult rats. Brain Res. 1169 (2007) 112-119
15. De Oliveira M.R., Silvestrin R.B., Mello e Souza T., and Moreira J.C.F. Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: effects of sub acute vitamin A supplementation at therapeutic doses. Neurotoxicology 28 (2007) 1191-1199
16. De Oliveira M.R., Silvestrin R.B., Mello e Souza T., and Moreira J.C.F. Therapeutic vitamin A doses increase the levels of markers of oxidative insult in substantia nigra and decrease locomotory and exploratory activity in rats after acute and chronic supplementation. Neurochem. Res. 33 (2008) 378-383
17. Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J. Neurochem. 97 (2006) 1634-1658
18. Moreira J.C.F., Dal-Pizzol F., Von Endt D., and Bernard E.A. Effect of retinol on chromatin structure in Sertoli cells: 1,10-phenanthroline inhibit the increased DNAse I sensitivity induced by retinol. Med. Sci. Res. 25 (1997) 635-638
19. Dal-Pizzol F., Klamt F., Frota Jr. M.L.C., Moraes L.F., Moreira J.C.F., and Benfato M.S. Retinol supplementation induces DNA damage and modulates iron turnover in rat Sertoli cells. Free Rad. Res. 33 (2000) 677-687
20. Dal-Pizzol F., Klamt F., Benfato M.S., Bernard E.A., and Moreira J.C.F. Retinol supplementation induces oxidative stress and modulate antioxidant enzyme activities in rat Sertoli cells. Free Rad. Res. 34 (2001) 395-404
21. Frota Jr. M.L.C., Klamt F., Dal-Pizzol F., Schiengold M., and Moreira J.C.F. Retinol-induced mdr1 and mdr3 modulation in cultured rat Sertoli cells is attenuated by free radical scavengers. Redox Rep. 9 (2004) 161-165
22. Dalmolin R.J., Zanotto-Filho A., De Oliveira R.B., Duarte R.F., Pasquali M.A., and Moreira J.C. Retinol and retinoic acid increase MMP-2 activity by different pathways in cultured Sertoli cells. Free Rad. Res. 41 (2007) 1338-1347
23. Zanotto-Filho A., Schröder R., and Moreira J.C.F. Xanthine oxidase-dependent ROS production mediates vitamin A pro-oxidant effects in cultured Sertoli cells. Free Rad. Res. 42 (2008) 593-601
24. Klamt F., De Oliveira M.R., and Moreira J.C.F. Retinol induces permeability transition and cytochrome c release from rat liver mitochondria. Biochim. Biophys. Acta 1726 (2005) 14-20
25. Klamt F., Dal-Pizzol F., Gelain D.P., Dalmolin R.S., Birnfeld de Oliveira R., Bastiani M., Horn F., and Fonseca Moreira J.C. Vitamin a treatment induces apoptosis through an oxidant-dependent activation of the mitochondrial pathway. Cell Biol. Int. 32 (2008) 100-116
26. Gao Q., and Horvath T.L. Neurobiology of feeding and energy expenditure. Annu. Rev. Neurosci. 30 (2007) 367-398
27. Mactier H., and Weaver L.T. Vitamin A and preterm infants: what we know, what we don't know, and what we need to know. Arch. Dis. Child Fetal Neonatal Ed. 90 (2005) 103-108
28. Lowry O.H., Rosebrough A.L., and Randal R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
29. Draper H.H., and Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 186 (1990) 421-431
30. Levine R.L., Garland D., Oliver C.N., Amici A., Climent I., Lenz A.G., Ahn B.W., Shaltiel S., and Stadman E.R. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186 (1990) 464-478
31. Misra H.P., and Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247 (1972) 3170-3175
32. Aebi H. Catalase in vitro. Methods Enzymol. 105 (1984) 121-126
33. Poderoso J.J., Carreras M.C., Lisdero C., Riobo N., Schopfer F., and Boveris A. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch. Biochem. Biophys. 328 (1996) 85-92
34. Shapira A.H., Mann V.M., Cooper J.M., Dexter D., Daniel S.E., Jenner P., Clark J.B., and Marsden C.D. Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J. Neurochem. 55 (1990) 2142-2145
35. Fischer J.C., Ruitenbeek W., Berden J.A., Trijbels J.M., Veerkamp J.H., Stadhouders M., Sengers R.C., and Janssen A.J. Differential investigation of the capacity of succinate oxidation in human skeletal muscle. Clin. Chim. Acta 153 (1985) 23-36
36. Rustin P., Chretien D., Bourgeron T., Gérard B., Rötig A., Saudubray J.M., and Munnich A. Biochemical and molecular investigations in respiratory chain deficiencies. Clin. Chim. Acta 228 (1994) 35-51
37. Norum K.R. Acute myeloid leukaemia and retinoids. Eur. J. Clin. Nutr. 47 (1993) 77-87
38. Samad T.A., Krezel W., Chambon P., and Borrelli E. Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 14349-14354
39. Bierhaus A., Humpert P.M., Morcos M., Wendt T., Chavakis T., Arnold B., Stern D.M., and Nawroth P.P. Understanding RAGE, the receptor for advanced glycation end products. J. Mol. Med. 83 (2005) 876-886
40. Brownlee M. Negative consequences of glycation. Metabolism 49 (2000) 9-13
41. Napoli J.L. Interactions of retinoids binding proteins and enzymes in retinoids metabolism. Biochim. Biophys. Acta 1440 (1999) 139-162
42. Manoli I., Alesci S., Blackman M.R., Su Y.A., Rennert O.M., and Chrousos G.P. Mitochondria as key components of the stress response. Trends Endocrinol. Metabol. 18 (2007) 190-198