Therapeutic vitamin A doses increase the levels of markers of oxidative insult in substantia nigra and decrease locomotory and exploratory activity in rats after acute and chronic supplementation

Neurochemical Research

Volumn 33, Issue 3, 2008, Pages 378-383

  De Oliveira, Marcos Roberto ^a   Silvestrin, Roberta Bristot ^a   Mello E Souza, Tadeu ^a   Moreira, José Cláudio Fonseca ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Behavior; Lipid peroxidation; Oxidative stress; Protein carbonylation; Rat substantia nigra; Vitamin A

Indexed keywords

BIOLOGICAL MARKER; CATALASE; GLUTATHIONE PEROXIDASE; LIPID; PROTEIN; RETINOL; SUPEROXIDE DISMUTASE; THIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; EXPLORATORY BEHAVIOR; LIPID PEROXIDATION; LOCOMOTION; LONG TERM EXPOSURE; MALE; NEUROTOXICITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; RAT; SUBSTANTIA NIGRA; VITAMIN SUPPLEMENTATION;

ANIMALS; BIOLOGICAL MARKERS; CATALASE; EXPLORATORY BEHAVIOR; GLUTATHIONE PEROXIDASE; MALE; MOTOR ACTIVITY; OXIDATIVE STRESS; PROTEIN CARBONYLATION; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR; SUBSTANTIA NIGRA; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN A;

RATTUS;

EID: 38949150010     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-007-9438-2     Document Type: Article

References (43)

1. Wolf G (1984) Multiple functions of vitamin A. Physiol Rev 64:873-937
2. Semba RD (1998) The role of vitamin A and related retinoids in immune function. Nutr Rev 56:S38-S48
3. McCaferry P, Zhang J, Crandall JE (2005) Retinoic acid signaling and function in the adult hippocampus. J Neurobiol 66:780-791
4. Krezel W, Ghyselinck N, Samad TA, Dupe V, Kastner P, Borrelli E, Chambon P (1998) Impaired locomotion and dopamine signaling in retinoids receptor mutant mice. Science 279:863-867
5. Samad TA, Krezel W, Chambon P, Borrelli E (1997) Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family. Proc Natl Acad Sci USA 94:14349-14354
6. Wang HF, Liu FC (2005) Regulation of multiple dopamine signal transduction molecules by retinoids in the developing striatum. Neuroscience 134:97-105
7. Bendich A, Langseth L (1989) Safety of vitamin A. Am J Clin Nutr 49:358-371
8. Myhre AM, Carlsen MH, Bohn SK, Wold HL, Laake P, Blomhoff R (2003) Water-miscible, emulsified, and solid forms of retinol supplements are more toxic than oil-based preparations. Am J Clin Nutr 78:1152-1159
9. Geelen JA (1979) Hypervitaminosis A induced teratogenesis. CRC Crit Rev Toxicol 6:351-375
10. O'Reilly KC, Shumake J, Gonzalez-Lima F, Lane MA, Bailey SJ (2006) Chronic administration of 13-cis-retinoic acid increases depression-related behavior in mice. Neuropsychopharmacol 31:1919-1927
11. Hazen PG, Carney JF, Walker AE, Stewart JJ (1983) Depression- a side effect of 13-cis-retinoic acid therapy. J Am Acad Dermatol 9:278-279
12. Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97:1634-1658
13. Abou-Sleiman P, Muqit MMK, Wood NW (2006) Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci 7:207-219
14. Zaidi SMKR, Banu N (2004) Antioxidant potential of vitamins A, E, and C in modulating oxidative stress in rat brain. Clin Chim Acta 340:229-233
15. Moreira JCF, Dal-Pizzol F, Von Endt D, Bernard EA (1997) Effect of retinol on chromatin structure in Sertoli cells: 1,10-phenanthroline inhibit the increased DNAse I sensitivity induced by retinol. Med Sci Res 25:635-638
16. Dal-Pizzol F, Klamt F, Frota MLC Jr, Moraes LF, Moreira JCF, Benfato MS (2000) Retinol supplementation induces DNA damage and modulates iron turnover in rat Sertoli cells. Free Rad Res 33:677-687
17. Klamt F, Dal-Pizzol F, Ribeiro NC, Bernard EA, Benfato MS, Moreira JCF (2000) Retinol-induced elevation in ornithine decarboxylase activity in cultured Sertoli cells is attenuated by free radical scavenger and by iron chelator. Mol Cell Biochem 208:71-76
18. Dal-Pizzol F, Klamt F, Benfato MS, Bernard EA, Moreira JCF (2001) Retinol supplementation induces oxidative stress and modulate antioxidant enzyme activity in rat Sertoli cells. Free Rad Res 34:395-404
19. Frota MLC Jr, Klamt F, Dal-Pizzol F, Schiengold M, Moreira JCF (2004) Retinol-induced mdr1 and mdr3 modulation in cultured rat Sertoli cells is attenuated by free radical scavengers. Redox Rep 9:161-165
20. Klamt F, De Oliveira MR, Moreira JCF (2005) Retinol induces permeability transition and cytochrome c release from rat liver mitochondria. Biochim Biophys Acta 1726:14-20
21. Gelain DP, Cammarota M, Zanotto-Filho A, De Oliveira RB, Dal-Pizzol F, Izquierdo I, Bevilaqua L, Moreira JCF (2006) Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells. Cell Signal 18:1685-1694
22. Cohen G, Farooqui R, Kesler N (1997) Parkinson disease: a new link between monoamine oxidase and mitochondrial electron flow. Proc Natl Acad Sci USA 94:4890-4894
23. Norum KR (1993) Acute myeloid leukaemia and retinoids. Eur J Clin Nutr 47:77-87
24. Lam HS, Chow CM, Poon WT, Lai CK, Yeung WL, Hui J, Chan AY, Ng PC (2006) Risk of vitamin A toxicity from candy-like chewable vitamin supplements for children. Pediatrics 118:820-824
25. Lowry OH, Rosebrough AL, Randal RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275
26. Draper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186:421-431
27. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadman ER (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464-478
28. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77
29. Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121-126
30. Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170-3175
31. Flohé L, Günzler WA (1984) Assays of glutathione peroxidase. Methods Enzymol 105:114-121
32. Hirsch EC (1992) Why are nigral catecholaminergic neurons more vulnerable than others in Parkinson's disease. Ann Neurol 32:S88-S93
33. Lotharius J, Brundin P (2002) Pathogenesis of Parkinson's disease: dopamine, vesicles and α-synuclein. Nat Rev Neurosci 3:932-942
34. Graham DG (1978) Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol Pharmacol 14:633-643
35. Dawson TM, Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302:819-822
36. Goetz ME, Gerlach M (2004) Formation of radicals. In: Herdegen T, Delgado-Garcia J (eds) Brain damage and repair. Kluwer, London, pp 135-164
37. Mattson MP, Magnus T (2006) Ageing and neuronal vulnerability. Nat Rev Neurosci 7:278-294
38. Fang YZ, Yang S, Wu G (2002) Free radicals, antioxidants, and nutrition. Nutrition 18:872-879
39. Hathcock JN, Hattan DG, Jenkins MY, McDonald JT, Sundaresan PR, Wilkening VL (1990) Evaluation of vitamin A toxicity. Am J Clin Nutr 52:183-202
40. Napoli JL (1999) Interactions of retinoids binding proteins and enzymes in retinoids metabolism. Biochim Biophys Acta 1440:139-162
41. Frame B, Jackson CE, Reynolds WA, Umphrey JE (1974) Hypercalcemia and skeletal effects in chronic hypervitaminosis A. Ann Intern Med 80:44-48
42. Ellis JK, Russel RM, Makrauer FL, Schaefer EJ (1986) Increased risk for vitamin A toxicity in severe hypertriglyceridemia. Ann Intern Med 105:877-879
43. Croquet V, Pilette C, Lespine A (2000) Hepatic hypervitaminosis A: importance of retinyl ester level determination. Eur J Gastroenterol Hepatol 12:361-364