Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer

Journal of Cancer Research and Clinical Oncology

Volumn 135, Issue 6, 2009, Pages 761-769

  Kang, Min Ah ^a   Kim, Jong Tae ^a   Kim, Joo Heon ^b   Kim, Soo Young ^b   Kim, Young Ho ^c   Yeom, Young Il ^a   Lee, Younghee ^d   Lee, Hee Gu ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Eulji University School of Medicine   (South Korea)

^c Samsung Medical Center   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

CDK1; CKS2; Gastric cancer; P53

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; PROTEIN P53; SMALL INTERFERING RNA;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER PATIENT; CELL GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INDUCTION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CARCINOMA; TUMOR DIFFERENTIATION; TUMOR VOLUME;

BLOTTING, WESTERN; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; PROTEIN KINASES; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STOMACH NEOPLASMS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 67349193572     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-008-0510-3     Document Type: Article

References (39)

1. SA Alhasan JF Ensley FH Sarkar 2000 Genistein induced molecular changes in a squamous cell carcinoma of the head and neck cell line Int J Oncol 16 333 338
2. SK Banerjee AP Weston MN Zoubine DR Campbell R Cherian 2000 Expression of cdc2 and cyclin B1 in Helicobacter pylori-associated gastric MALT and MALT lymphoma: relationship to cell death, proliferation, and transformation Am J Pathol 156 217 225 (Pubitemid 30644455)
3. WS El-Deiry T Tokino VE Velculescu DB Levy R Parsons JM Trent D Lin WE Mercer KW Kinzler B Vogelstein 1993 WAF1, a potential mediator of p53 tumor suppression Cell 75 817 825 (Pubitemid 23346378)
4. W El-Rifai HF Frierson Jr JC Harper SM Powell S Knuutila 2001 Expression profiling of gastric adenocarcinoma using cDNA array Int J Cancer 92 832 838 (Pubitemid 32467372)
5. D Ganoth G Bornstein TK Ko B Larsen M Tyers M Pagano A Hershko 2001 The cell-cycle regulatory protein Cks1 is required for SCF (Skp2)-mediated ubiquitinylation of p27 Nat Cell Biol 3 321 324 (Pubitemid 32201330)
6. M Gostissa TG Hofmann H Will G Del Sal 2003 Regulation of p53 functions: let's meet at the nuclear bodies Curr Opin Cell Biol 15 351 357 (Pubitemid 36638655)
7. J Haaber N Abildgaard LM Knudsen IM Dahl M Lodahl M Thomassen GB Kerndrup T Rasmussen 2008 Myeloma cell expression of 10 candidate genes for osteolytic bone disease. Only overexpression of DKK1 correlates with clinical bone involvement at diagnosis Br J Haematol 140 25 35 (Pubitemid 350233249)
8. DE Hansel S Dhara RC Huang R Ashfaq M Deasel Y Shimada HS Bernstein J Harmon M Brock A Forastiere MK Washington A Maitra E Montgomery 2005 CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target Am J Surg Pathol 29 390 399 (Pubitemid 40321976)
9. J Hayles S Aves P Nurse 1986 suc1 is an essential gene involved in both the cell cycle and growth in fission yeast Embo J 5 3373 3379
10. J Hayles D Beach B Durkacz P Nurse 1986 The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function Mol Gen Genet 202 291 293 (Pubitemid 16159578)
11. K Kawakami H Enokida T Tachiwada T Gotanda K Tsuneyoshi H Kubo K Nishiyama M Takiguchi M Nakagawa N Seki 2006 Identification of differentially expressed genes in human bladder cancer through genome-wide gene expression profiling Oncol Rep 16 521 531
12. K Krause M Wasner W Reinhard U Haugwitz CL Dohna J Mossner K Engeland 2000 The tumour suppressor protein p53 can repress transcription of cyclin B Nucleic Acids Res 28 4410 4418
13. K Krause U Haugwitz M Wasner M Wiedmann J Mossner K Engeland 2001 Expression of the cell cycle phosphatase cdc25C is down-regulated by the tumor suppressor protein p53 but not by p73 Biochem Biophys Res Commun 284 743 750 (Pubitemid 32924792)
14. Y Lan Y Zhang J Wang C Lin MM Ittmann F Wang 2008 Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death Int J Cancer 123 543 551
15. M Li YM Lin S Hasegawa T Shimokawa K Murata M Kameyama O Ishikawa T Katagiri T Tsunoda Y Nakamura Y Furukawa 2004 Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray Int J Oncol 24 305 312
16. CC Lin SY Lin JG Chung JP Lin GW Chen ST Kao 2006 Down-regulation of cyclin B1 and upregulation of Wee1 by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle Anticancer Res 26 1097 1104
17. HM Lin A Chatterjee YH Lin A Anjomshoaa R Fukuzawa JL McCall AE Reeve 2007 Genome wide expression profiling identifies genes associated with colorectal liver metastasis Oncol Rep 17 1541 1549
18. X Lu J Guo TC Hsieh 2003 PC-SPES inhibits cell proliferation by modulating p21, cyclins D, E and B and multiple cell cycle-related genes in prostate cancer cells Cell Cycle 2 59 63
19. HS Martinsson-Ahlzen V Liberal B Grunenfelder SR Chaves CH Spruck SI Reed 2008 Cyclin dependent kinase associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells Mol Cell Biol 28 5698 5709
20. TA Masuda H Inoue K Nishida H Sonoda Y Yoshikawa Y Kakeji T Utsunomiya M Mori 2003 Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma Clin Cancer Res 9 5693 5698 (Pubitemid 37499492)
21. R Medina M van der Deen A Miele-Chamberland RL Xie AJ van Wijnen JL Stein GS Stein 2007 The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes Cancer Res 67 10334 10342 (Pubitemid 350070808)
22. J Pines 1996 Cell cycle: reaching for a role for the Cks proteins Curr Biol 6 1399 1402
23. A Rivera A Mavila KJ Bayless GE Davis SA Maxwell 2006 Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells Cell Mol Life Sci 63 1425 1439 (Pubitemid 43939022)
24. K Rother C Johne K Spiesbach U Haugwitz K Tschop M Wasner L Klein-Hitpass T Moroy J Mossner K Engeland 2004 Identification of Tcf-4 as a transcriptional target of p53 signaling Oncogene 23 3376 3384 (Pubitemid 38669827)
25. K Rother M Dengl J Lorenz K Tschop R Kirschner J Mossner K Engeland 2007 Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73 FEBS Lett 581 1166 1172 (Pubitemid 46385940)
26. IN Roublevskaia BV Polevoda JW Ludlow AR Haake 2000 Induced G2/M arrest and apoptosis in human epidermoid carcinoma cell lines by semisynthetic drug Ukrain Anticancer Res 20 3163 3167
27. CA Scrideli CG Carlotti Jr OK Okamoto VS Andrade MA Cortez FJ Motta AK Lucio-Eterovic L Neder S Rosemberg SM Oba-Shinjo SK Marie LG Tone 2008 Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR J Neurooncol 88 281 291
28. CJ Sherr 1994 G1 phase progression: cycling on cue Cell 79 551 555 (Pubitemid 24363798)
29. SP Singh J Lipman H Goldman FH Ellis Jr L Aizenman MG Cangi S Signoretti DS Chiaur M Pagano M Loda 1998 Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma Cancer Res 58 1730 1735 (Pubitemid 28215101)
30. C Spruck H Strohmaier M Watson AP Smith A Ryan TW Krek SI Reed 2001 A CDK-independent function of mammalian Cks1: targeting of SCF (Skp2) to the CDK inhibitor p27Kip1 Mol Cell 7 639 650 (Pubitemid 32706355)
31. CH Spruck MP de Miguel AP Smith A Ryan P Stein RM Schultz AJ Lincoln PJ Donovan SI Reed 2003 Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis Science 300 647 650 (Pubitemid 36520590)
32. M Stanbrough GJ Bubley K Ross TR Golub MA Rubin TM Penning PG Febbo SP Balk 2006 Increased expression of genes converting adrenal androgens to testosterone in androgen independent prostate cancer Cancer Res 66 2815 2825
33. Y Uchikado H Inoue N Haraguchi K Mimori S Natsugoe H Okumura T Aikou M Mori 2006 Gene expression profiling of lymph node metastasis by oligomicroarray analysis using laser microdissection in esophageal squamous cell carcinoma Int J Oncol 29 1337 1347
34. I Urbanowicz-Kachnowicz N Baghdassarian C Nakache D Gracia Y Mekki PA Bryon M Ffrench 1999 ckshs expression is linked to cell proliferation in normal and malignant human lymphoid cells Int J Cancer 82 98 104 (Pubitemid 29266113)
35. KH Vousden X Lu 2002 Live or let die: the cell's response to p53 Nat Rev Cancer 2 594 604 (Pubitemid 37328926)
36. AH Wiese J Auer S Lassmann J Nahrig R Rosenberg H Hofler R Ruger M Werner 2007 Identification of gene signatures for invasive colorectal tumor cells Cancer Detect Prev 31 282 295
37. YF Wong TH Cheung GS Tsao KW Lo SF Yim VW Wang MM Heung SC Chan LK Chan TW Ho KW Wong C Li Y Guo TK Chung DI Smith 2006 Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray Int J Cancer 118 2461 2469
38. K Xu C Belunis W Chu D Weber F Podlaski KS Huang SI Reed LT Vassilev 2003 Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase Biochem J 371 957 964 (Pubitemid 36578894)
39. J Yun HD Chae HE Choy J Chung HS Yoo MH Han DY Shin 1999 p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor J Biol Chem 274 29677 29682 (Pubitemid 29483335)