The effects of yohimbine and amphetamine on fear expression and extinction in rats

Psychopharmacology

Volumn 204, Issue 4, 2009, Pages 599-606

  Mueller, Devin ^a,d   Olivera Figueroa, Lening A ^b   Pine, Daniel S ^c   Quirk, Gregory J ^a  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^b PONCE SCHOOL OF MEDICINE   (Puerto Rico)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

2 Adrenoceptor antagonist; Anxiety disorders; Bar press suppression; Fear conditioning; Fear extinction; Freezing; Norepinephrine; Psychostimulant; Reuptake blocker

Indexed keywords

AMPHETAMINE; YOHIMBINE;

ANIMAL EXPERIMENT; ANXIETY DISORDER; ARTICLE; DOSE RESPONSE; DRUG DOSE COMPARISON; FEAR; FREEZING; LEARNING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; TRAINING;

ADRENERGIC ALPHA-ANTAGONISTS; AMPHETAMINE; ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM STIMULANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTINCTION, PSYCHOLOGICAL; FEAR; FREEZING REACTION, CATALEPTIC; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; YOHIMBINE;

EID: 67349185545     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-009-1491-x     Document Type: Article

References (50)

1. CW Berridge 2006 Neural substrates of psychostimulant-induced arousal Neuropsychopharmacology 31 2332 2340 (Pubitemid 44607049)
2. CA Blaiss PH Janak 2007 Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach Neurobiol Learn Mem 87 644 658 (Pubitemid 46505110)
3. TB Borowski L Kokkinidis 1998 The effects of cocaine, amphetamine, and the dopamine D1 receptor agonist SKF 38393 on fear extinction as measured with potentiated startle: implications for psychomotor stimulant psychosis Behav Neurosci 112 952 965 (Pubitemid 28397378)
4. ME Bouton 2002 Context, ambiguity, and unlearning: sources of relapse after behavioral extinction Biol Psychiatry 52 976 986 (Pubitemid 35356355)
5. ME Bouton RC Bolles 1980 Conditioned fear assessed by freezing and by the suppression of three different baselines Anim Learn Behav 8 429 434 (Pubitemid 11218674)
6. S Cabib C Orsini M Le Moal PV Piazza 2000 Abolition and reversal of strain differences in behavioral responses to drugs of abuse after a brief experience Science 289 463 465 (Pubitemid 30490460)
7. CK Cain AM Blouin M Barad 2004 Adrenergic transmission facilitates extinction of conditional fear in mice Learn Mem 11 179 187 (Pubitemid 38456600)
8. JP Chhatwal M Davis KA Maguschak KJ Ressler 2005 Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear Neuropsychopharmacology 30 516 524 (Pubitemid 40271154)
9. P Chopin S Pellow SE File 1986 The effects of yohimbine on exploratory and locomotor behavior are attributable to its effects at noradrenaline and not at benzodiazepine receptors Neuropharmacology 25 53 57 (Pubitemid 16188196)
10. JA Davies B Jackson PH Redfern 1974 The effect of amantadine, L-dopa, (plus)-amphetamine and apomorphine on the acquisition of the conditioned avoidance response Neuropharmacology 13 199 204
11. PB Dews 1953 The measurement of the influence of drugs on voluntary activity in mice Br J Pharmacol 8 46 48
12. S Fenu G Di Chiara 2003 Facilitation of conditioned taste aversion learning by systemic amphetamine: role of nucleus accumbens shell dopamine D1 receptors Eur J Neurosci 18 2025 2030 (Pubitemid 37372384)
13. TD Geracioti Jr DG Baker NN Ekhator SA West KK Hill AB Bruce D Schmidt B Rounds-Kugler R Yehuda PE Keck Jr JW Kasckow 2001 CSF norepinephrine concentrations in posttraumatic stress disorder Am J Psychiatry 158 1227 1230 (Pubitemid 32717695)
14. TD Geracioti Jr LL Carpenter MJ Owens DG Baker NN Ekhator PS Horn JR Strawn G Sanacora B Kinkead LH Price CB Nemeroff 2006 Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression Am J Psychiatry 163 637 643 (Pubitemid 44464573)
15. MR Goldberg D Robertson 1983 Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor Pharmacol Rev 35 143 180 (Pubitemid 14216352)
16. AJ Guastella R Richardson PF Lovibond RM Rapee JE Gaston P Mitchell MR Dadds 2008 A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder Biol Psychiatry 63 544 549
17. K Hefner N Whittle J Juhasz M Norcross RM Karlsson LM Saksida TJ Bussey N Singewald A Holmes 2008 Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse train J Neurosci 28 8074 8085
18. SG Hofmann MH Pollack MW Otto 2006 Augmentation treatment of psychotherapy for anxiety disorders with D-cycloserine CNS Drug Rev 12 208 217 (Pubitemid 46047788)
19. AL Johnston SE File 1989 Yohimbine's anxiogenic action: evidence for noradrenergic and dopaminergic sites Pharmacol Biochem Behav 32 151 156 (Pubitemid 19125930)
20. T Kikusui Y Takeuchi Y Mori 2001 Pharmacological manipulations of the extinction process of fear-induced ultrasonic vocalization in rats J Vet Med Sci 63 591 595 (Pubitemid 33641620)
21. R Kumar 1971 Extinction of fear. I. Effects of amylobarbitone and dexamphetamine given separately and in combination on fear and exploratory behaviour in rats Psychopharmacologia 19 163 187
22. L Ledgerwood R Richardson J Cranney 2003 Effects of D-cycloserine on extinction of conditioned freezing Behav Neurosci 117 341 349 (Pubitemid 36384252)
23. H Majczynski A Cabaj U Slawinska T Gorska 2006 Intrathecal administration of yohimbine impairs locomotion in intact rats Behav Brain Res 175 315 322 (Pubitemid 44750235)
24. JL Martinez Jr RA Jensen RB Messing BJ Vasquez B Soumireu-Mourat D Geddes KC Liang JL McGaugh 1980 Central and peripheral actions of amphetamine on memory storage Brain Res 182 157 166 (Pubitemid 10173700)
25. ST Mason H Fibiger 1979 Noradrenaline, fear and extinction Brain Res 165 47 56 (Pubitemid 9166770)
26. K Mason DJ Heal SC Stanford 1998 The anxiogenic agents, yohimbine and FG 7142, disrupt the noradrenergic response to novelty Pharmacol Biochem Behav 60 321 327 (Pubitemid 28282671)
27. M Mast RJ Blanchard DC Blanchard 1982 The relationship of freezing and response suppression in a CER situation Psychol Rec 32 151 167
28. DA McCormick RF Thompson 1982 Locus coeruleus lesions and resistance to extinction of a classically conditioned response: involvement of the neocortex and hippocampus Brain Res 245 239 249 (Pubitemid 12038377)
29. JL McGaugh 2000 Memory-a century of consolidation Science 287 248 251
30. MR Milad SP Orr NB Lasko Y Chang SL Rauch RK Pitman 2008 Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study J Psychiatr Res 42 515 520
31. RW Morris ME Bouton 2007 The effect of yohimbine on the extinction of conditioned fear: a role for context Behav Neurosci 121 501 514 (Pubitemid 47445103)
32. D Mueller JT Porter GJ Quirk 2008 Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction J Neurosci 28 369 375
33. KM Myers M Davis 2007 Mechanisms of fear extinction Mol Psychiatry 12 120 150 (Pubitemid 46160979)
34. RE O'Carroll E Drysdale L Cahill P Shajahan KP Ebmeier 1999 Stimulation of the noradrenergic system enhances and blockade reduces memory for emotional material in man Psychol Med 29 1083 1088 (Pubitemid 29469298)
35. SP Orr LJ Metzger NB Lasko ML Macklin T Peri RK Pitman 2000 De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder J Abnorm Psychol 109 290 298 (Pubitemid 30616926)
36. DS Pine JA Cohen 2002 Trauma in children and adolescents: risk and treatment of psychiatric sequelae Biol Psychiatry 51 519 531 (Pubitemid 34327327)
37. GJ Quirk D Mueller 2008 Neural mechanisms of extinction learning and retrieval Neuropsychopharmacology 33 56 72 (Pubitemid 350191313)
38. GJ Quirk GK Russo JL Barron K Lebron 2000 The role of ventromedial prefrontal cortex in the recovery of extinguished fear J Neurosci 20 6225 6231 (Pubitemid 30658416)
39. RA Rescorla 2004 Spontaneous recovery Learn Mem 11 501 509 (Pubitemid 39299696)
40. KJ Ressler BO Rothbaum L Tannenbaum P Anderson K Graap E Zimand L Hodges M Davis 2004 Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear Arch Gen Psychiatry 61 1136 1144 (Pubitemid 39463415)
41. Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ (2009) Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction. Biol Psychiatry (in press).
42. E Soetens R D'Hooge JE Hueting 1993 Amphetamine enhances human-memory consolidation Neurosci Lett 161 9 12 (Pubitemid 23311052)
43. E Soetens S Casaer R D'Hooge JE Hueting 1995 Effect of amphetamine on long-term retention of verbal material Psychopharmacology (Berl) 119 155 162
44. SM Southwick JH Krystal JD Bremner CA Morgan III AL Nicolaou LM Nagy DR Johnson GR Heninger DS Charney 1997 Noradrenergic and serotonergic function in posttraumatic stress disorder Arch Gen Psychiatry 54 749 758 (Pubitemid 27344103)
45. SM Southwick CA Morgan III DS Charney JR High 1999 Yohimbine use in a natural setting: effects on posttraumatic stress disorder Biol Psychiatry 46 442 444 (Pubitemid 29335928)
46. G Telegdy M Fekete M Balazs T Kadar 1983 Effects of a new antidepressant drug on active avoidance behavior in rats. Comparative study with tricyclic antidepressants Arch Int Pharmacodyn Ther 266 50 59 (Pubitemid 14210709)
47. A Tobena A Fernandez-Terual RM Escorihuela JF Nunez P Ferre R Sanchez 1993 Limits of habituation and extinction: implications for relapse prevention programs in addictions Drug Alcohol Depend 32 209 217
48. DL Walker KJ Ressler KT Lu M Davis 2002 Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats J Neurosci 22 2343 2351 (Pubitemid 35386533)
49. SC Wood SG Anagnostaras 2008 Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice Psychopharmacology 202 197 206
50. K Zushida M Sakurai K Wada M Sekiguchi 2007 Facilitation of extinction learning for contextual fear memory by PEPA: a potentiator of AMPA receptors J Neurosci 27 158 166 (Pubitemid 46089970)