Concentrations of chlorinated and brominated contaminants and their metabolites in serum of harbour seals and harbour porpoises

Environment International

Volumn 35, Issue 6, 2009, Pages 842-850

  Weijs, Liesbeth ^a,b   Das, Krishna ^c   Siebert, Ursula ^d   van Elk, Niels ^e   Jauniaux, Thierry ^c   Neels, Hugo ^b   Blust, Ronny ^a   Covaci, Adrian ^a,b  

^a Ecophysiology   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d UNIVERSITY OF KIEL   (Germany)

^e Dolfinarium Harderwijk   (Netherlands)

Author keywords

Harbour porpoises; Harbour seals; HO PCBs; MeO PBDEs; Metabolites; North Sea; PBDEs; PCBs; Serum

Indexed keywords

BIOMOLECULES; BODY FLUIDS; MAMMALS; METABOLITES; POLYCHLORINATED BIPHENYLS;

HARBOUR PORPOISE; HARBOUR SEAL; MEO-PBDES; NORTH SEA; PBDES; SERUM;

ORGANIC POLLUTANTS;

POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL;

BIOACCUMULATION; METABOLITE; PBDE; PCB; PINNIPED; PORPOISE; SERUM;

AGE DETERMINATION; ARTICLE; BLOOD ANALYSIS; CONCENTRATION PROCESS; FEMALE; LACTATION; LIFESPAN; MALE; METABOLIC CAPACITY; NONHUMAN; PHOCA; PORPOISE; PRIORITY JOURNAL; SEAL; SEX DIFFERENCE; SPECIES DIFFERENCE; WATER POLLUTION; WEIGHT REDUCTION;

ATLANTIC OCEAN; NORTH SEA;

ANIMALIA; PHOCA VITULINA; PHOCOENA PHOCOENA; PHOCOENIDAE;

EID: 67349170502     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2009.02.001     Document Type: Article

References (73)

1. Bang K., Jenssen B.M., Lydersen C., and Skaare J.U. Organochlorine burdens in blood of ringed and bearded seals from north-western Svalbard. Chemosphere 44 (2001) 193-203
2. Benedict R.T., Stapleton H.M., Letcher R.J., and Mitchelmore C.L. Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes. Chemosphere 69 (2007) 987-993
3. Beineke A., Siebert U., McLachlan M., Bruhn R., Thron K., Failing K., et al. Investigations of the potential influence of environmental contaminants on the thymus and spleen of harbor porpoises (Phocoena phocoena). Environ Sci Technol 39 (2005) 3933-3938
4. Birnbaum L.S., and Staskal D.F. Brominated flame retardants: cause for concern?. Environ Health Perspect 112 (2004) 9-17
5. Boon J.P., Reijnders P.J.H., Dols J., Wensvoort P., and Hillebrand M.T.J. The kinetics of individual polychlorinated biphenyl congeners in female harbour seals (Phoca vitulina), with evidence for structure-related metabolism. Aquat Toxicol 10 (1987) 307-324
6. Boon J.P., van der Meer J., Allchin C.R., Law R.J., Klungsoyr J., Leonards P.E.G., et al. Concentration-dependent changes of PCB patterns in fish-eating mammals: structural evidence for induction of cytochrome P450. Arch Environ Contam Toxicol 33 (1997) 298-311
7. Boon J.P., Lewis W.E., Tjoen-A-Choy M.R., Allchin C.R., Law R.J., de Boer J., et al. Levels of polybrominated diphenyl ether (PBDE) flame retardants in animals representing different trophic levels of the North Sea food web. Environ Sci Technol 36 (2002) 4025-4032
8. Bossart G.D. Emerging diseases in marine mammals: from dolphins to manatees. Microbe 2 (2007) 544-549
9. Bruhn R., Kannan N., Petrick G., Schulz-Bull D.E., and Duinker J.C. CB pattern in the harbour porpoise: bioaccumulation, metabolism and evidence for cytochrome P450 IIB activity. Chemosphere 31 (1995) 3721-3732
10. Burns J.J. Harbor seal and spotted seal Phoca vitulina and P. largha. In: Perrin W.F., Würsig B., and Thewissen J.G.M. (Eds). Encyclopedia of marine mammals vol. 1 (2002), Academic Press, San Diego 552-560
11. Cheek A.O., Kow K., Chen J., and McLachlan J.A. Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect 107 (1999) 273-278
12. Chu S., Covaci A., Haraguchi K., Voorspoels S., Van de Vijver K., Das K., et al. Levels and enantiomeric signatures of methyl sulfonyl PCB and DDE metabolites in livers of harbor porpoises (Phocoena phocoena) from the Southern North Sea. Environ Sci Technol 37 (2003) 4573-4578
13. Covaci A., and Voorspoels S. Optimization of the determination of polybrominated diphenyl ethers in human serum using solid-phase extraction and gas chromatography-electron capture negative ionization mass spectrometry. J Chromatogr B 827 (2005) 216-223
14. Covaci A., Van de Vijver K., De Coen W., Das K., Bouquegneau J.M., Blust R., et al. Determination of organohalogenated contaminants in liver of harbour porpoises (Phocoena phocoena) stranded on the Belgian North Sea coast. Mar Pollut Bull 44 (2002) 1157-1165
15. Damstra T., Barlow S., Bergman Å., Kavlock R., and Van Der Kraak G. Global assessment of the state-of-science of endocrine disruptors, International Programme on Chemical Safety (2002), World Health Organization
16. 15N measurements. Mar Ecol Prog Ser 263 (2003) 287-298
17. Das K., Vossen A., Tolley K., Vikingsson G., Thron K., Müller G., et al. Interfollicular fibrosis in the thyroid of the harbour porpoise: an endocrine disruption?. Arch Environ Contam Toxicol 51 (2006) 720-729
18. Debier C., Pomeroy P.P., Dupont C., Joiris C., Comblin V., Le Boulengé E., et al. Quantitative dynamics of PCB transfer from mother to pup during lactation in UK grey seals, Halichoerus grypus. Mar Ecol Prog Ser 247 (2003) 237-248
19. Debier C., Pomeroy P.P., Dupont C., Joiris C., Comblin V., Le Boulengé E., et al. Dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation period. Mar Ecol Prog Ser 247 (2003) 249-256
20. Debier C., Chalon C., Le Boeuf B.J., De Tillesse T., Larondelle Y., and Thomé J.P. Mobilization of PCBs from blubber to blood in northern elephant seals (Mirounga angustirostris) during the post-weaning fast. Aquat Toxicol 80 (2006) 149-157
21. de Boer J., Wester P.G., Klamer H.J.C., Lewis W.E., and Boon J.P. Do flame retardants threaten ocean life?. Nature 394 (1998) 28-29
22. Dorneles, P.R., Lailson-Brito, J., Covaci, A., Dirtu, A.C., Weijs, L., Azevedo, A.F., et al., Anthropogenic and naturally-produced organobrominated compounds in marine mammals from Brazil. Environ Pollut, submitted for publication.
23. Dunkin R.C., McLellan W.A., Blum J.E., and Pabst D.A. The ontogenetic changes in the thermal properties of blubber from Atlantic bottlenose dolphin Tursiops truncatus. J Exp Biol 208 (2005) 1469-1480
24. Gebbink W.A., Sonne C., Dietz R., Kirkegaard M., Riget F.F., Born E.W., et al. Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). Environ Pollut 152 (2008) 621-629
25. Haglund P.S., Zook D.R., Buser H.R., and Hu J. Identification and quantification of polybrominated diphenyl ethers and methoxy-polybrominated diphenyl ethers in Baltic biota. Environ Sci Technol 31 (1997) 3281-3287
26. Hammond P.S., Berggren P., Benke H., Borchers D.L., Collet A., Heide-Jørgensen M.P., et al. Abundance of harbour porpoise and other cetaceans in the North Sea and adjacent waters. J Appl Ecol 39 (2002) 361-376
27. Hasselmeier I., Fonfara S., Driver J., and Siebert U. Differential hematology profiles of free-ranging, rehabilitated, and captive harbor seals (Phoca vitulina) of the German North Sea. Aquat Mammals 34 (2008) 149-156
28. Hobbs K.E., Lebeuf M., and Hammill M.O. PCBs and OCPs in male harbour, grey, harp and hooded seals from the Estuary and Gulf of St Lawrence, Canada. Sci Total Environ 296 (2002) 1-18
29. Hoekstra P.F., Letcher R.J., O'Hara T.M., Backus S.M., Solomon K.R., and Muir D.C.G. Hydroxylated and methylsulfone-containing metabolites of polychlorinated biphenyls in the plasma and blubber of bowhead whales (Balaena mysticetus). Environ Toxicol Chem 22 (2003) 2650-2658
30. Houde M., Pacepavicius G., Wells R.S., Fair P.A., Letcher R.J., Alaee M., et al. Polychlorinated biphenyls and hydroxylated polychlorinated biphenyls in plasma of bottlenose dolphins (Tursiops truncatus) from the Western Atlantic and the Gulf of Mexico. Environ Sci Technol 40 (2006) 5860-5866
31. Hutchinson J.D., and Simmonds M.P. Organochlorine contamination in Pinnipeds. Rev Environ Contam Toxicol 136 (1994) 123-167
32. Huwe J.K., and Smith D.J. Accumulation, whole-body depletion, and debromination of decabromodiphenyl ether in male Sprague-Dawley rats following dietary exposure. Environ Sci Technol 41 (2007) 2371-2377
33. Jaspers V.L.B., Dirtu A.C., Eens M., Neels H., and Covaci A. Predatory birds species show different patterns of hydroxylated polychlorinated biphenyls (HO-PCBs) and polychlorinated biphenyls (PCBs). Environ Sci Technol 42 (2008) 3465-3471
34. Kajiwara N., Kannan K., Muraoka M., Watanabe M., Takahashi S., Gulland F., et al. Organochlorine pesticides, polychlorinated biphenyls, and butyltin compounds in blubber and livers of stranded California sea lions, elephant seals, and harbor seals from coastal California, USA. Arch Environ Contam Toxicol 41 (2001) 90-99
35. Kastelein R.A., van der Sijs S.J., Staal C., and Nieuwstraten S.H. Blubber thickness in harbour porpoises (Phocoena phocoena). In: Read A.J., Wiepkema P.R., and Nachtigall P.E. (Eds). The biology of harbour porpoise (1997), De Spill Publishers, Woerden, The Netherlands 179-199
36. Kelly B.C., Ikonomou M.G., Blair J.D., and Gobas F.A.P.C. Hydroxylated and methoxylated polybrominated diphenyl ethers in a Canadian Arctic marine food web. Environ Sci Technol 42 (2008) 7069-7077
37. Koopman H.N., Iverson S.J., and Gaskin D.E. Stratification and age-related differences in blubber fatty acids of the male harbour porpoise (Phocoena phocoena). J Comp Physiol B 165 (1996) 628-639
38. Letcher R.J., Klasson-Wehler E., and Bergman Å. Methyl sulfone and hydroxylated metabolites of polychlorinated biphenyls. In: Paasivirta J. (Ed). The Handbook of Environmental Chemistry (2000), Springer-Verlag, Berlin Heidelberg 315-359
39. Lockyer C. All creatures great and smaller: a study in cetacean life history energetics. J Mar Biol Assoc UK 87 (2007) 1035-1045
40. Løken K.B., Lie E., Sørmo E.G., Jenssen B.M., and Skaare J.U. How important are the hydroxylated PCB metabolites (OH-PCB) in harbour seals (Phoca vitulina)?. Organohalog Compd 70 (2008) 25-28
41. Marsh G., Athanasiadou M., Athanassiadis I., Bergman A., Endo T., and Haraguchi K. Identification, quantification and synthesis of a novel dimethoxylated polybrominated biphenyl in marine mammals caught off the coast of Japan. Environ Sci Technol 39 (2005) 8684-8690
42. McKinney M.A., De Guise S., Martineau D., Béland P., Arukwe A., and Letcher R.J. Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale (Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay. Aquat Toxicol 77 (2006) 87-97
43. McKinney M.A., De Guise S., Martineau D., Béland P., Lebeuf M., and Letcher R.J. Organohalogen contaminants and metabolites in beluga whale (Delphinapterus leucas) liver from two Canadian populations. Environ Toxicol Chem 25 (2006) 1246-1257
44. Meerts I.A., van Zanden J.J., Luijks E.A., Leeuwen-Bol I., Marsh G., Jakobsson E., et al. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci 6 (2000) 95-104
45. Meijer L., Weiss J., Van Velzen M., Brouwer A., Bergman Å., and Sauer P.J.J. Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands. Environ Sci Technol 42 (2008) 3428-3433
46. Melcher J., Olbrich D., Marsh G., Nikiforov V., Gaus C., Gaul S., et al. Tetra- and tribromophenoxyanisoles in marine samples from Oceania. Environ Sci Technol 39 (2005) 7784-7789
47. Montie E.W., Fair P.A., Bossart G.D., Mitchum G.B., Houde M., Muir D.C.G., et al. Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States. Aquat Toxicol 86 (2008) 397-412
48. Pirard C., and De Pauw E. Absorption, disposition and excretion of polybrominated diphenyl ethers (PBDEs) in chicken. Chemosphere 66 (2007) 320-325
49. Reijnders P.J.H., and Aguilar A. Pollution and marine mammals. In: Perrin W.E., Würisg B., and Thewissen J.G.M. (Eds). Encyclopedia of marine mammals (2002), Academic Press 948-957
50. Reijnders P., and Simmonds M.P. Global temporal trends of organochlorines and heavy metals in pinnipeds. Toxicology of marine mammals (2003), Taylor & Francis, London 491-506
51. Ross P. Fireproof killer whales (Orcinus orca): flame retardant chemicals and the conservation imperative in the charismatic icon of British Columbia, Canada. Can J Fish Aquat Sci 63 (2006) 224-234
52. Ruus A., Ugland K.I., Espeland O., and Skaare J.U. Organochlorine contaminants in a local marine food chain from Jarfjord, Northern Norway. Mar Environ Res 48 (1999) 131-146
53. Sandala G.M., Sonne-Hansen C., Dietz R., Muir D.C.G., Valters K., Bennett E.R., et al. Hydroxylated and methyl sulfone PCB metabolites in adipose and whole blood of polar bear (Ursus maritimus) from East Greenland. Sci Total Environ 331 (2004) 125-141
54. Sandau C.D., Meerts I.A.T.M., Letcher R.J., McAlees A.J., Chittim B., Brouwer A., et al. Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transthyretin: a metabolite of octachlorostyrene?. Environ Sci Technol 34 (2000) 3871-3877
55. Shaw S.D., Brenner D., Bourakovsky A., Mahaffey C.A., and Perkins C.R. Polychlorinated biphenyls and chlorinated pesticides in harbor seals (Phoca vitulina concolor) from the northwestern Atlantic coast. Mar Pollut Bull 50 (2005) 1069-1084
56. Shaw S.D., Brenner D., Berger M.L., Fang F., Hong C.S., Storm R., et al. PBDEs, PCBs and dioxin-like PCBs in harbor seals from the northwestern Atlantic. Organohalog Compd 69 (2007) 829-832
57. Shimokawa N., Miyazaki W., Iwasaki T., and Koibuchi N. Low dose hydroxylated PCB induces c-Jun expression in PC12 cells. NeuroToxicology 27 (2006) 176-183
58. Siebert U., Wünschmann A., Weiss R., Frank H., Benke H., and Frese K. Post mortem findings in harbour porpoises (Phocoena phocoena) from the German North and Baltic Sea. J Comp Pathol 124 (2001) 102-114
59. Sørmo, E.G. Organochlorine pollutants in grey seal (Halichoerus grypus) pups and their impact on plasma thyroid hormone and vitamin A concentrations. Faculty of Natural Sciences and Technology. Trondheim, Norway, Norwegian University of Science and Technology (NTNU). Dr. scient. thesis: 73 pp; 2005.
60. Sørmo E.G., Skaare J.U., Lydersen C., Kovacs K.M., Hammill M.O., and Jenssen B.M. Partitioning of persistent organic pollutants in grey seal (Halichoerus grypus) mother-pup pairs. Sci Total Environ 302 (2003) 145-155
61. Stapleton H.M., Alaee M., Letcher R.J., and Baker J.E. Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure. Environ Sci Technol 38 (2004) 112-119
62. Tanabe S., Iwata H., and Tatsukawa R. Global contamination by persistent organochlorines and their ecotoxicological impact on marine mammals. Sci Total Environ 154 (1994) 163-177
63. Teuten E.L., and Reddy C.M. Halogenated organic compounds in archived whale oil: a pre-industrial record. Environ Pollut 145 (2007) 668-671
64. Thomas G.O., Moss S.E.W., Asplund L., and Hall A.J. Absorption of decabromodiphenyl ether and other organohalogen chemicals by grey seals (Halichoerus grypus). Environ Pollut 133 (2005) 581-586
65. Thron K.U., Bruhn R., and McLachlan M.S. The influence of age, sex, body-condition, and region on the levels of PBDEs and toxaphene in harbour porpoises from European waters. Fresenius Environ Bull 13 (2004) 146-155
66. Troisi G.M., Haraguchi K., Kaydoo D.S., Nyman M., Aguilar A., Borrell A., et al. Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims. J Toxicol Environ Health A 62 (2001) 1-8
67. Van den Steen E., Covaci A., Jaspers V.L.B., Dauwe T., Voorspoels S., Eens M., et al. Accumulation, tissue-specific distribution and debromination of decabromodiphenyl ether (BDE 209) in European starlings (Sturnus vulgaris). Environ Pollut 148 (2007) 648-653
68. Vetter W., Luckas B., Heidemann G., and Skirnisson K. Organochlorine residues in marine mammals from the Northern hemisphere - a consideration of the composition of organochlorine residues in the blubber of marine mammals. Sci Total Environ 86 (1996) 29-39
69. Vetter W. Marine halogenated natural products of environmental relevance. Rev Environ Contam Toxicol 188 (2006) 1-57
70. Weijs L., Dirtu A.C., Das K., Gheorghe A., Reijnders P.J.H., Neels H., et al. Inter-species differences for polychlorinated biphenyls and polybrominated diphenyl ethers in marine top predators from the Southern North Sea: part 1. Accumulation patterns in harbour seals and harbour porpoises. Environ Pollut 157 (2009) 437-444
71. Weijs L., Dirtu A.C., Das K., Gheorghe A., Reijnders P.J.H., Neels H., et al. Inter-species differences for polychlorinated biphenyls and polybrominated diphenyl ethers in marine top predators from the Southern North Sea: part 2. Biomagnification in harbour seals and harbour porpoises. Environ Pollut 157 (2009) 445-451
72. Weiss J., Wallin E., Axmon A., Jonsson B.A.G., Akesson H., Janak K., et al. Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density. Environ Sci Technol 40 (2006) 6282-6289
73. Young D., Becerra M., Kopec D., and Echols S. GC/MS analysis of PCB congeners in blood of the harbor seal Phoca vitulina from San Francisco Bay. Chemosphere 37 (1998) 711-733