Transgenic expression of matrix metalloproteinase-9 modulates collagen deposition in a mouse model of atherosclerosis

Atherosclerosis

Volumn 205, Issue 1, 2009, Pages 107-112

  Lemaître, Vincent ^a   Kim, Henry E ^a,b   Forney Prescott, Margaret ^c   Okada, Yasunori ^d   D'Armiento, Jeanine ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b HENRY FORD HOSPITAL   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d KEIO UNIVERSITY   (Japan)

Author keywords

Collagen; Matrix metalloproteinase; Mouse model of atherosclerosis

Indexed keywords

COLLAGEN; GELATINASE B; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; COLLAGEN METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID DIET; MACROPHAGE; MICROANEURYSM; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SUPERNATANT; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; AORTA; ATHEROSCLEROSIS; COLLAGEN; GENE EXPRESSION REGULATION; HUMANS; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; TRANSFORMING GROWTH FACTOR BETA; TRANSGENES;

EID: 67349160215     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.11.030     Document Type: Article

References (29)

1. Lusis A.J. Atherosclerosis. Nature 407 (2000) 233-241
2. Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
3. Galis Z.S., Sukhova G.K., Lark M.W., and Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94 (1994) 2493-2503
4. Thompson R.W., Holmes D.R., Mertens R.A., et al. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J Clin Invest 96 (1995) 318-326
5. Brown D.L., Hibbs M.S., Kearney M., Loushin C., and Isner J.M. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation 91 (1995) 2125-2131
6. Zhang B., Ye S., Herrmann S.M., et al. Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation 99 (1999) 1788-1794
7. Cho A., and Reidy M.A. Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury. Circ Res 91 (2002) 845-851
8. Galis Z.S., Johnson C., Godin D., et al. Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling. Circ Res 91 (2002) 852-859
9. Luttun A., Lutgens E., Manderveld A., et al. Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth. Circulation 109 (2004) 1408-1414
10. Johnson J.L., George S.J., Newby A.C., and Jackson C.L. Divergent effects of matrix metalloproteinases 3, 7, 9 and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries. Proc Natl Acad Sci USA 102 (2005) 15575-15580
11. Pyo R., Lee J.K., Shipley J.M., et al. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 105 (2000) 1641-1649
12. Gibbs D.F., Warner R.L., Weiss S.J., Johnson K.J., and Varani J. Characterization of matrix metalloproteinases produced by rat alveolar macrophages. Am J Respir Cell Mol Biol 20 (1999) 1136-1144
13. Jeng A.Y., Chou M., Sawyer W.K., et al. Enhanced expression of matrix metalloproteinase-3, -12, and -13 mRNAs in the aortas of apolipoprotein E-deficient mice with advanced atherosclerosis. Ann NY Acad Sci 878 (1999) 555-558
14. Lemaître V., Soloway P.D., and D'Armiento J. Increased medial degradation with pseudoaneurysm formation in apoE knockout mice deficient in Tissue inhibitor of metalloproteinases-1. Circulation 107 (2003) 333-338
15. Horvai A., Palinski W., Wu H., et al. Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions. Proc Natl Acad Sci USA 92 (1995) 5391-5395
16. Lemaître V., O'Byrne T.K., Borczuk A.C., et al. ApoE knockout mice expressing human matrix metalloproteinase-1 in their macrophages have less advanced atherosclerosis. J Clin Invest 107 (2001) 1227-1234
17. Kozaki K., Kaminski W.E., Tang J., et al. Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice. Am J Pathol 161 (2002) 1395-1407
18. Fukumoto Y., Libby P., Rabkin E., et al. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits. Circulation 103 (2001) 993-999
19. Ray J.L., Leach R., Herbert J.M., and Benson M. Isolation of vascular smooth muscle cells from a single murine aorta. Methods Cell Sci 23 (2001) 185-188
20. Abe M., Harpel J.G., Metz C.N., et al. An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 216 (1994) 276-284
21. Morishige K., Shimokawa H., Matsumoto Y., et al. Overexpression of matrix metalloproteinase-9 promotes intravascular thrombus formation in porcine coronary arteries in vivo. Cardiovasc Res 57 (2003) 572-585
22. Gough P.J., Gomez I.G., Wille P.T., and Raines E.W. Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J Clin Invest 116 (2006) 59-69
23. Newby A.C. Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 85 (2005) 1-31
24. Mallat Z., Gojova A., Marchiol-Fournigault C., et al. Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 89 (2001) 930-934
25. Lutgens E., Gijbels M., Smook M., et al. Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. Arterioscler Thromb Vasc Biol 22 (2002) 975-982
26. Yu Q., and Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis. Genes Dev 14 (2000) 163-166
27. Lee C.G., Homer R.J., Zhu Z., et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 194 (2001) 809-821
28. Ogata Y., Itoh Y., and Nagase H. Steps involved in activation of the pro-matrix metalloproteinase 9 (progelatinase B)-tissue inhibitor of metalloproteinases-1 complex by 4-aminophenylmercuric acetate and proteinases. J Biol Chem 270 (1995) 18506-18511
29. Fridman R., Toth M., Chvyrkova I., Meroueh S.O., and Mobashery S. Cell surface association of matrix metalloproteinase-9 (gelatinase B). Cancer Metastasis Rev 22 (2003) 153-166