Influence of drug polarity upon the solid-state structure and release properties of self-emulsifying drug delivery systems in relation with water affinity

Colloids and Surfaces B: Biointerfaces

Volumn 71, Issue 1, 2009, Pages 73-78

  Chambin, O ^a   Karbowiak, T ^b   Djebili, L ^a   Jannin, V ^c   Champion, D ^b   Pourcelot, Y ^a   Cayot, P ^b  

^a EA 581   (France)

^b Physico chemical Group   (France)

^c GATTEFOSSÉ SAS   (France)

Author keywords

Drug polarity; Gelucire 44 14; Self emulsifying drug delivery system; Solid state structure; Water affinity

Indexed keywords

CHEMICAL STRUCTURES; DRUG POLARITY; IN-VITRO DISSOLUTIONS; MATRIXES; MODEL DRUGS; NAPROXEN; PHYSICO-CHEMICAL PROPERTIES; POORLY WATER-SOLUBLE DRUGS; SELF-EMULSIFYING DRUG DELIVERY SYSTEM; SOLID-STATE STRUCTURE; SURFACE WETTABILITIES; THERMAL BEHAVIOURS; WATER AFFINITY; WATER SOLUBILITIES; WATER-SOLUBLE DRUGS;

BIOCHEMISTRY; DISSOLUTION; DRUG DELIVERY; SODIUM; SOLUBILITY;

EMULSIFICATION;

GELUCIRE; NAPROXEN; WATER;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; HYDROPHOBICITY; IN VITRO STUDY; PRIORITY JOURNAL; WETTABILITY;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG DELIVERY SYSTEMS; EMULSIFYING AGENTS; HYDROPHOBICITY; KINETICS; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; WATER;

EID: 67349140974     PISSN: 09277765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2009.01.008     Document Type: Article

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