A novel ex vivo skin model for the assessment of the potential transcutaneous anti-inflammatory effect of topically applied Harpagophytum procumbens extract

International Journal of Pharmaceutics

Volumn 376, Issue 1-2, 2009, Pages 63-68

  Ouitas, Nassima Abdelouahab ^a   Heard, Charles M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

5 LOX; COX 2; Devil's Claw; H. procumbens; Inflammation; iNOS; PGE 2; Skin; Transcutaneous delivery

Indexed keywords

8 O PARA COUMAROYL HARPAGIDE; ACTEOSIDE; ALCOHOL; CYCLOOXYGENASE 2; GLYCOSIDE; HARPAGIDE; HARPAGOPHYTUM PROCUMBENS EXTRACT; HARPAGOSIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOXYGENASE; PLANT MEDICINAL PRODUCT; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MEMBRANE; CELL TYPE; CONTROLLED STUDY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; EX VIVO STUDY; IMMUNOCYTOCHEMISTRY; NONHUMAN; POWDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SKIN CELL; SWINE; WESTERN BLOTTING;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DINOPROSTONE; HARPAGOPHYTUM; LIPOXYGENASE; MODELS, IMMUNOLOGICAL; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PLANT TUBERS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SKIN; SKIN ABSORPTION; SWINE;

EID: 67349102312     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.04.017     Document Type: Article

References (23)

1. Abdelouahab N., and Heard C.M. Dermal and transcutaneous delivery of the major glycosides constituents of H. procumbens (Devil's Claw) in vitro. Planta Med. 74 (2008) 527-531
2. Abdelouahab N., and Heard C.M. Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro. J. Nat. Prod. 71 (2008) 746-749
3. Aggarwal B., Shishodia S., Sandur S.K., Pandey M.K., and Sethi G. Inflammation and cancer: how hot is the link?. Biochem. Pharm. 72 (2006) 1605-1621
4. Baghdikian B., Lanhers M.C., Fleurentin J., Ollivier E., Maillard C., Balansard G., and Mortier F. An analytical study: anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeheri. Planta Med. 63 (1997) 171-176
5. Benito P.B., Lanza A.M.D., Sen A.M.S., Galindez J.D., Matellano L.F., Gomez A.S., and Martinez M.J.A. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Med. 66 (2000) 324-328
6. Chantre P., Cappelaere D., Leblan D., Guedon J., Vandermander J., and Fournie B. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 7 (2000) 177-183
7. Chrubasik S., Zimper C., Schuett U., and Ziegler R. Effectiveness of Harpagophytum procumbens in treatment of acute low back pain. Phytomedicine 3 (1996) 1-10
8. Chrubasik S., Conradt C., and Roufogalis B.D. Effectiveness of Harpagophytum extracts and clinical efficacy. Phytother. Res. 18 (2004) 187-189
9. Chun K.S., Keum Y.S., Han S.S., Song Y.S., Kim S.H., and Surh Y.J. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-κB activation. Carcinogenesis 24 (2003) 1515-1524
10. Eich J., Schmidt M., and Betti G. HPLC analysis of iridoid compounds of Harpagophytum taxa: quality control of pharmaceutical drug material. Pharmacol. Lett. 8 (1998) 75-78
11. Ernst E., and Chrubasik S. Phyto-anti-inflammatories: a systematic review of randomised, placebo-controlled, double-blind trials. Rheum. Dis. Clin. North Am. 26 (2000) 13-27
12. Escribano E., Calpena A.C., Queralt J., Obach R., and Doménech J. Assessment of diclofenac permeation with different formulations: anti-inflammatory study of a selected formula. Eur. J. Pharmacol. Sci. 19 (2003) 203-210
13. Fiebich B.L., Heinrich M., Hiller K.O., and Kammerer N. Inhibition of TNF-a synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 8 (2001) 28-30
14. Joubert E., Manly M., Gray B.R., and Schulz H. Rapid measurement and evaluation of the effect of drying conditions on harpagoside content in Harpagophytum procumbens (Devil's Claw) root. J. Agric. Food Chem. 53 (2005) 3493-3502
15. Kaszkin M., Beck K.F., Koch E., Erdelmeier C., Kusch S., Pfeilschifter J., and Loew D. Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. Phytomedicine 11 (2004) 585-595
16. Kundu J.K., Mossanda K.S., Na H.K., and Surh Y.J. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Can. Lett. 218 (2005) 21-31
17. Lin L.C., Wang Y.H., Hou Y.C., Chang S., Liou K.T., Chou Y.C., Wang W.Y., and Shen Y.C. The inhibitory effect of phenylpropanoid glycosides and iridoid glucosides on free radical production and beta 2 integrin expression in human leucocytes. J. Pharm. Pharmacol. 58 (2006) 129-135
18. Ling S.K., Tanaka T., and Kouno I. Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by beta-glucosidase in the presence of amino acids. Biol. Pharm. Bull. 26 (2003) 352-356
19. Marcouiller P., Pelletier J.P., Guevremont M., Martel-Pelletier J., Ranger P., Laufer S., and Reboul P. Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1 beta synthesis. J. Rheum. 32 (2005) 704-712
20. Moussard C., Alber D., Toubin M.M., Thevenon N., and Henry J.S. A drug used in traditional medicine, Harpagophytum procumbens: no evidence for nsaid-like effect on whole blood eicosanoid production in human. Prostag. Leukotr. Ess. 46 (1992) 283-286
21. Thomas C.P., Davison Z., and Heard C.M. Probing the skin permeation of fish oil/EPA and ketoprofen 3. Influence of fish oil/ketoprofen on epidermal COX-2 and LOX. Prostag. Leukotr. Ess. 76 (2007) 357-362
22. Tippler B., Syrovets T., Plaza N., Loew D., and Simmet T. Harpagophytum procumbens DC used in traditional medicine inhibits eicosanoid biosynthesis in human whole blood. Int. J. Tissue React. 19 (1997) 101-102
23. Wegener T. Devil's claw: from African traditional remedy to modern analgesic and anti-inflammatory. Herbal Gram. 50 (2000) 47-54