Phyto-anti-inflammatories: A systemic review of randomized, placebo- controlled, double-blind trials

Rheumatic Disease Clinics of North America

Volumn 26, Issue 1, 2000, Pages 13-27

  Ernst, Edzard ^a   Chrubasik, Sigruu ^b  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; AYURVEDIC DRUG; BLACKCURRANT SEED OIL; BORAGE SEED OIL; FRAXINUS EXCELSIOR EXTRACT; GAMMA LINOLENIC ACID; HARPAGOPHYTUM EXTRACT; HARPAGOSIDE; HERBACEOUS AGENT; LINOLENIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PHYTODOLOR; POPULUS TREMULA EXTRACT; PRIMROSE OIL; SALICIN; SOLIDAGO VIRGAUREA EXTRACT; UNCLASSIFIED DRUG; URTICA DIOICA EXTRACT; URTICA EXTRACT; VEGETABLE OIL; WILLOW BARK EXTRACT; WITHANIA SOMNIFERA EXTRACT;

ANTIINFLAMMATORY ACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CURCUMA LONGA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG RESEARCH; FEVER; GASTROINTESTINAL SYMPTOM; HUMAN; ICOSANOID METABOLISM; LOW BACK PAIN; MAJOR CLINICAL STUDY; MORNING STIFFNESS; OSTEOARTHRITIS; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; TANACETUM PARTHENIUM; TRADITIONAL MEDICINE; TREATMENT OUTCOME;

EID: 0033962441     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-857X(05)70117-4     Document Type: Article

References (58)

1. M.J. Abad P. Bermejo E. Carretero Antiinflammatory activity of some medicinal plant extracts from Venezuela J Ethnopharmacol 55 1996 63 68
2. P.A. Akah A.I. Nwambie Evaluation of Nigerian traditional medicines: 1. Plants used for rheumatic (inflammatory) disorders J Ethnopharmacol 42 1994 179 182
3. B.H. Ali A.K. Bashir M.O.M. Tanira Anti-inflammatory, antipyretic, and analgesic effects of Lawsonia inermis L. (Henna) in rats Pharmacology 51 1995 356 363
4. J.A. Astin Why patients use alternative medicine. Results of a national study JAMA 279 1998 1548 1553
5. R. Bauer A. Holz S. Chrubasik Kaffeoyläpfelsäure als Leitsubstanz in Brennesselzubereitungen Chrubasik S. Wink M. Rheumatherapie mit Phytopharmaka 1996 Hippokrates-Verlag Stuttgart 112 120
6. D. Baumann G. Focke G. Kornosoff Phytodolor bei Patienten mit aktivierter Gonarthrose, Koxathrose bzw Schulter-Arm-Syndrom Multizentrische randomisierte Doppelblindstudie versus Diclofenac-Natrium 1989 Steigerwald GmbH Interner Forschungsbericht Darmstadt
7. J.J.F. Belch D. Ansell R. Madhok Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: A double blind placebo controlled study Ann Rheum Dis 47 1988 96 104
8. Bernhardt M, Keimel A, Belucci G, et al: Doppelblinde, randomisierte Vergleichstudie von Phytodolor N und Placebo sowie offener Vergleich zu Felden 20 Tabs bei stationaren Kurpatienten mit arthrotischen Gelenkveränderungen. Unpublished trial. Darmstadt, Steigerwald GmbH, 1991
9. M. Bernhardt B. Keimel U. Dormehl Vergleich der Wirksamkeit und Verträglichkeit von Phytodolor N in verschiedenen Konzentrationen bei Erkrankungen rheumatischer Genese 1990 Steigerwald GmbH Darmstadt Unpublished trial
10. B.S. Bloom Direct medical costs of disease and gastrointestinal side-effects during treatment for arthritis Am J Med 84 1988 20 24
11. M. Brzeski R. Madhok H.A. Capell Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs Br J Rheumatol 30 1991 370 372
12. S. Chrubasik F. Sporer M. Wink Zum Wirkstoffgehalt in Arzneimitteln aus Harpagophytum procumbens Forsch Komplementärmed 3 1996 57 63
13. Chrubasik S. Zimpfer Ch. U. Schütt Effectiveness of Harpagophytum procumbens in treatment of acute low back pain Phytomedicine 3 1996 1 10
14. Chrubasik S, Junck H, Breitschwerdt H, et al: Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: A randomized placebo-controlled double-blind study. Eur J Anaesthesiol, in press
15. S. Chrubasik W. Enderlein R. Bauer Evidence for antirheumatic effectiveness of stewed Herba urticae dioicae in acute arthritis: A pilot study Phytomedicine 4 1997 105 108
16. S. De B. Ravishankar G.C. Bhavsar Investigation of the anti-inflammatory effects of Paederia foetida [abstract] J Ethnopharmacol 43 1994 31 38
17. P. Dolara C. Luceri C. Ghelardini Analgesic effects of myrrh Nature 379 1996 29
18. D. Eisenberg R.B. David S.L. Ettner Trends in alternative medicine use in the United States, 1990–1997 JAMA 280 1998 1569 1575
19. E. Ernst Harmless herbs? A review of the recent literature Am J Med 104 1998 170 178
20. E. Ernst Over-the-counter complementary therapies used for arthritis Pharmaceutical Journal 260 1998 830 831
21. E. Ernst Usage of complementary therapies in rheumatology: A systematic review Clin Rheumatol 17 1998 301 305
22. E. Ernst M. Willoughby T.H. Weihmayr Nine possible reasons for choosing complementary medicine Perfusion 8 1995 356 358
23. Ernst E. De Smet P.A.G.M. D. Shaw Traditional remedies and the “test of time.” Eur J Clin Pharmacol 54 1998 100 199
24. European Scientific Cooperative of Phytotherapy monographs ISBN-1 901964019
25. M.B. Ferraz R.B. Pereira N.M. Iwata Tipi. A popular analgesic tea: A double-blind cross-over trial in osteoarthritis Clin Exp Rheumatol 9 1991 205 206
26. M. Guyader Les plantes antirheumatismales Etudes historique et pharmacologique, et etude clinique du nebulisat d' Harpagophytum procumbens DC chez 50 patients arthrosiques suivis en service hospitalier [dissertation] 1984 Universite Pierre et Marie Curie Paris
27. S. Hahn U. Hübner-Steiner Behandlung schmerzhafter rheumatischer Erkrankungen mit Phytodolor im Verglerch zur Placebo- und Ammuno-Behandlung Rheund, Sehmerz und Entzündung 8 1988 55 58
28. R. Hawel Phytodolor vs Diclofenac bei rheumatischen Erkrankungen Darmstadt 1991 Steigerwald GmbH, Interner Forschungsbericht
29. U. Herzog J. Fitzek H. Franek Phytodolor N versus Diclofenac: Wirksamkeit und Verträglichkeit 1991 Steigerwald GmbH Interner Forschungsbericht Darmstadt
30. Huber von B. Therapie degenerativer rheumatischer Erkrankungen Fortschr Med 109 1991 248 250
31. A.R. Jadad A. Moore D. Carroll Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 17 1996 1 12
32. J. Jäntti T. Nikkari T. Solakivi Evening primrose oil in rheumatoid arthritis: Changes in serum lipids and fatty acids Ann Rheum Dis 48 1989 124 127
33. R.R. Kulkarni P.S. Patki V.P. Jog Treatment of osteoarthritis with a herbomineral formulation: A double-blind, placebo-controlled, cross-over study J Ethnopharmacol 33 1991 91 95
34. M. Larhsini H.B. Lazrek H. Amarouch Investigation of antifungal and analgesic activities of extracts from Sium nodiflorum J Ethnopharmacol 53 1996 105 110
35. A. Larsen I. Petersson B. Svensson Podophyllum derivatives (CPH 82) compared with placebo in the treatment of rheumatoid arthritis Br J Rheumatol 28 1989 124 127
36. A. Lecomte J.P. Costa Harpagophytum dans l'arthrose: Etudes en double insu contre placebo 37°2 Le Magazine 15 1992 27 30
37. L.J. Leventhal E.G. Boyce R.B. Zurier Treatment of rheumatoid arthritis with gammalinolenic acid Ann Intern Med 119 1993 867 873
38. L.J. Leventhal E.G. Boyce R.B. Zurier Treatment of rheumatoid arthritis with blackcurrant seed oil Br J Rheumatol 33 1994 847 852
39. J.S. Levine Mistoprostol and nonsteroidal anti-inflammatory drugs: A tale of effects, outcomes, and cost Ann Intern Med 123 1995 309 310
40. Li S.-H. Y. Kobayashi Y. Yamauchi Suppressive effects of a herbal formula, TBL-1, on type II collagen–induced arthritis in DBA/1J mice Clin Exp Pharmacol Physiol 23 1996 236 240
41. Lin C.-C. Chen M.-F. Chen C.-F. The anti-inflammatory effects of Chinese crude drug prescriptions on experimental arthritis Am J Chin Med 23 1995 145 152
42. Martínez-Vázquez M. Ramírez Apan T.O. A.L. Lastra A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata Planta Med 64 1998 134 137
43. S.Y. Mills R.K. Jacoby M. Chacksfield Effect of a proprietary herbal medicine on the relief of chronic arthritic pain: A double-blind study Br J Rheumatol 35 1996 874 878
44. J.L. Muller K.A. Clauson Pharmaceutical considerations of common herbal medicine American Journal of Managed Care 3 1997 1753 1770
45. G.M. Ostendorf So-called alternative therapies in rheumatology and orthopaedics Aktuelle Rheumatologie 22 1997 75 80
46. M. Pattrick S. Heptinstall M. Doherty Feverfew in rheumatoid arthritis: A double-blind, placebo controlled study Ann Rheum Dis 48 1989 547 549
47. J.M. Prieto M.C. Recio R.M. Giner Topical anti-inflammatory lignans from Haplophyllum hispanicum Z Naturorsch [C] 51 1996 618 622
48. W.J. Pugh K. Sambo Prostaglandin synthetase inhibitors in feverfew J Pharm Pharmacol 40 1998 743 745
49. 1 receptors Pain 75 1998 111 119
50. O. Sander G. Herborn R. Rau Ist H15 (Harzextrakt von Boswellia serrata, “Weihrauch”) eine sinnvolle Ergänzung zur etablierten medikamentösen Therapie der chronischen Polyarthritis?–Ergebnisse einer doppelblinden Pilotstudie Z Rheumatol 57 1998 11 16
51. W. Schadler Phytodolor N zur Behandlung aktivierter Arthrosen Rheuma 8 1988 280 290
52. W. Schaffner Eidenrinde–Ein Antiarrheumatikum der modernen Phytotherapie? Chrubasik S. Wink M. Rheumatherapie mit Phytopharmaka 1997 Hippokrates-Verlag Stuttgart 125 127
53. F. Schreckenberger Die Behandlung von Epicondylitiden mit Phytodolor Österreichische Zeitschrift für Allgemeinmedizin 42 1988 1638 1644
54. B. Tippler T. Syrovets D. Loew Harpagophytum procumbens : Wirkung von Extrakten auf die Eicosanoidbiosynthese in lonophor A23187–stimuliertem menschlichem Vollblut Loew D. Rietbrock N. Phytopharmaka II. Forschung und klinische Anwendung 1996 Steinkopf-Verlag Darmstadt 95 100
55. H. Tunón C. Olavsdotter L. Bohlin Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis J Ethnopharmacol 48 1995 61 76
56. A. Vodja Vergleich der Wirksamkeit und Verträglichkeit von Phytodolor–und Indometacin-Tabletten bei Patienten mit rheumatoider Arthritis 1992 Steigerwald GmbH Interner Forschungbericht Darmstadt
57. T. Xue-Lian D. Yi Z. Nei-Zheng A double-blind controlled study of Tripterygium wilfordii hook F (T2) in rheumatoid arthritis (RA) Arthritis Rheum 30 suppl 1987 S59
58. R.B. Zurier R.G. Rossetti E.W. Jacobson Gamma-linolenic acid treatment of rheumatoid arthritis Arthritis Rheum 39 1996 1808 1817