Thrombin generation and D-dimer concentrations in a patient cohort investigated for venous thromboembolism. Relations to venous thrombosis, factor V Leiden and prothrombin G20210A. The LIST study

Thrombosis Research

Volumn 124, Issue 2, 2009, Pages 178-184

  Chaireti, Roza ^a   Jennersjö, Cecilia ^a   Lindahl, Tomas L ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

APC resistance; D dimer; FV Leiden; Prothrombin mutation; Thrombin generation; Thrombosis; Venous thromboembolism

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5 LEIDEN; D DIMER; PROTHROMBIN;

ADULT; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC LINKAGE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHLEBOGRAPHY; PRIORITY JOURNAL; THROMBIN TIME; VEIN THROMBOSIS; VENOUS THROMBOEMBOLISM;

ACTIVATED PROTEIN C RESISTANCE; CASE-CONTROL STUDIES; COHORT STUDIES; FACTOR V; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; GENETIC MARKERS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; MIDDLE AGED; MUTATION; OUTPATIENTS; PROTHROMBIN; SEX FACTORS; SPECIMEN HANDLING; SWEDEN; THROMBIN; VENOUS THROMBOEMBOLISM; VENOUS THROMBOSIS;

EID: 67249118937     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2008.12.033     Document Type: Article

References (52)

1. Zoller B., Holm J., Svensson P., and Dahlback B. Elevated levels of prothrombin activation fragment 1 + 2 in plasma from patients with heterozygous Arg506 to Gln mutation in the factor V gene (APC-resistance) and/or inherited protein S deficiency. Thromb Haemost 75 (1996) 270-274
2. Dahlback B. New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg506 to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis. Thromb Haemost 74 (1995) 139-148
3. Dati F., Pelzer H., and Wagner C. Relevance of markers of hemostasis activation in obstetrics/gynecology and pediatrics. Semin Thromb Hemost 24 (1998) 443-448
4. Barber M., Langhorne P., Rumley A., Lowe G.D., and Stott D.J. Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression. Stroke 35 (2004) 1421-1425
5. Castoldi E., and Rosing J. Factor V Leiden: a disorder of factor V anticoagulant function. Curr Opin Hematol 11 (2004) 176-181
6. De Lucia D., Papa M.L., Ammendola F., Pezzella S., Del Giudice V., Marotta R., et al. Association of elevated levels of prothrombin fragment 1 + 2 and Arg506 to Gln mutation in patients with a history of ischemic stroke. J Neurosurg Sci 43 (1999) 45-50 discussion 50-51
7. Tans G., van Hylckama Vlieg A., Thomassen M.C., Curvers J., Bertina R.M., Rosing J., et al. Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women. Br J Haematol 122 (2003) 465-470
8. Arkel Y.S., Paidas M.J., and Ku D.H. The use of coagulation activation markers (soluble fibrin polymer, TpP, prothrombin fragment 1.2, thrombin-antithrombin, and D-dimer) in the assessment of hypercoagulability in patients with inherited and acquired prothrombotic disorders. Blood Coagul Fibrinolysis 13 (2002) 199-205
9. Folsom A.R., Cushman M., Tsai M.Y., Aleksic N., Heckbert S.R., Boland L.L., et al. A prospective study of venous thromboembolism in relation to factor V Leiden and related factors. Blood 99 (2002) 2720-2725
10. Gouin-Thibault I., Arkam R., Nassiri S., de la Tourette A., Conard J., Horellou M.H., et al. Markers of activated coagulation in patients with factor V Leiden and/or G20210A prothrombin gene mutation. Thromb Res 107 (2002) 7-11
11. Andreescu A.C., Cushman M., and Rosendaal F.R. D-dimer as a risk factor for deep vein thrombosis: the Leiden Thrombophilia Study. Thromb Haemost 87 (2002) 47-51
12. Curvers J., Thomassen M.C., Rimmer J., Hamulyak K., van der Meer J., Tans G., et al. Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test. Thromb Haemost 88 (2002) 5-11
13. Hron G., Kollars M., Binder B.R., Eichinger S., and Kyrle P.A. Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation. JAMA 296 (2006) 397-402
14. Qaseem A., Snow V., Barry P., Hornbake E.R., Rodnick J.E., Tobolic T., et al. Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians. Ann Fam Med 5 (2007) 57-62
15. Nicolaes G.A., and Dahlback B. Factor V and thrombotic disease: description of a janus-faced protein. Arterioscler Thromb Vasc Biol 22 (2002) 530-538
16. Margaglione M., Brancaccio V., De Lucia D., Martinelli I., Ciampa A., Grandone E., et al. Inherited thrombophilic risk factors and venous thromboembolism: distinct role in peripheral deep venous thrombosis and pulmonary embolism. Chest 118 (2000) 1405-1411
17. Castoldi E., Brugge J.M., Nicolaes G.A., Girelli D., Tans G., and Rosing J. Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations. Blood 103 (2004) 4173-4179
18. Hemker H.C., Al Dieri R., De Smedt E., and Beguin S. Thrombin generation, a function test of the haemostatic-thrombotic system. Thromb Haemost 96 (2006) 553-561
19. Wolberg A.S. Thrombin generation assays: understanding how the method influences the results. Thromb Res 119 (2007) 663-665
20. Brummel-Ziedins K., Vossen C.Y., Rosendaal F.R., Umezaki K., and Mann K.G. The plasma hemostatic proteome: thrombin generation in healthy individuals. J Thromb Haemost 3 (2005) 1472-1481
21. Brummel-Ziedins K.E., Vossen C.Y., Butenas S., Mann K.G., and Rosendaal F.R. Thrombin generation profiles in deep venous thrombosis. J Thromb Haemost 3 (2005) 2497-2505
22. Chantarangkul V., Clerici M., Bressi C., Giesen P.L., and Tripodi A. Thrombin generation assessed as endogenous thrombin potential in patients with hyper- or hypo-coagulability. Haematologica 88 (2003) 547-554
23. Jennersjo C.M., Fagerberg I.H., Karlander S.G., and Lindahl T.L. Normal D-dimer concentration is a common finding in symptomatic outpatients with distal deep vein thrombosis. Blood Coagul Fibrinolysis 16 (2005) 517-523
24. Gerotziafas G.T., Depasse F., Busson J., Leflem L., Elalamy I., and Samama M.M. Towards a standardization of thrombin generation assessment: Theinfluence of tissue factor, platelets and phospholipid concentration on the normal values of Thrombogram-Thrombinoscope assay. Thromb J 26 (2005) 3-16
25. van Hylckama Vlieg A., Christiansen S.C., Luddington R., Cannegieter S.C., Rosendaal F.R., and Baglin T.P. Elevated endogenous thrombin potential is associated with an increased risk of a first venous thrombosis but not with the risk of recurrence. Br J Haemat 138 (2007) 769-774
26. Tappenden K.A., Gallimore M.J., Evans G., Mackie I.J., and Jones D.W. Thrombin generation: a comparison of assays using platelet-poor and -rich plasma and whole blood samples from healthy controls and patients with a history of venous thromboembolism. Br J Haematol 139 (2007) 106-112
27. Martinelli I., Bottasso B., Duca F., Faioni E., and Mannucci P.M. Heightened thrombin generation in individuals with resistance to activated protein C. Thromb Haemost 75 (1996) 703-705
28. Cosmi B., and Palareti G. D-dimer, oral anticoagulation, and venous thromboembolism recurrence. Semin Vasc Med 5 (2005) 365-370
29. Dahlback B., and Villoutreix B.O. Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol 25 (2005) 1311-1320
30. Nomura H., Wada H., Mizuno T., Katayama N., Abe Y., Noda M., et al. Negative predictive value of D: -dimer for diagnosis of venous thromboembolism. Int J Hematol 87 (2008) 250-255
31. Brugge J.M., Simioni P., Bernardi F., Tormene D., Lunghi B., Tans G., et al. Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation. J Thromb Haemost 3 (2005) 2695-2702
32. Simioni P., Castoldi E., Lunghi B., Tormene D., Rosing J., and Bernardi F. An underestimated combination of opposites resulting in enhanced thrombotic tendency. Blood 106 (2005) 2363-2365
33. Hochuli M., Duewell S., and Frauchiger B. Quantitative d-dimer levels and the extent of venous thromboembolism in CT angiography and lower limb ultrasonography. Vasa 36 (2007) 267-274
34. Mann K.G. Thrombin formation. Chest 124 (2003) 4-10
35. Haidl H., Cimenti C., Leschnik B., Zach D., and Muntean W. Age-dependency of thrombin generation measured by means of calibrated automated thrombography (CAT). Thromb Haemost 95 (2006) 772-775
36. Rosing J., Hemker H.C., and Tans G. Molecular biology and pathophysiology of APC resistance: current insights and clinical implications. Semin Thromb Hemost 24 (1998) 329-335
37. Butenas S., van't Veer C., and Mann K.G. 'Normal' thrombin generation. Blood 94 (1999) 2169-2178
38. Esmon C. The protein C pathway. Crit Care Med 28 (2000) S44-48
39. van't Veer C., kalafatis M., Bertina R.M., Simioni P., and Mann K.G. Increased tissue factor-initiated prothrombin activation as a result of the Arg506 -> Gln mutation in factor VLEIDEN. J Biol Chem 272 (1997) 20721-20729
40. Koeleman B.P., Reitsma P.H., Allaart C.F., and Bertina R.M. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 84 (1994) 1031-1035
41. van Bonen H.H., Reitsma P.H., Rosendaal F.R., Bayston T.A., Chowdhury V., Bauer K.A., et al. Factor V Leiden (FV R506Q) in families with inherited antithrombin deficiency. Thromb Haemost 75 (1996) 417-421
42. Hillarp A., Zoller B., Svensson P.J., and Dahlback B. The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis. Thromb Haemost 78 (1997) 990-992
43. Strandberg K., Svensson P.J., and Ohlin A.K. Venous thromboembolism in carriers of the Factor V Leiden mutation and in patients without known thrombophilic risk factor; prediction of recurrence and APC-PCI complex concentration and/or soluble thrombomodulin antigen and activity. Thromb Res 121 (2007) 145-151
44. Vandenbroucke J.P., Koster T., Briet E., Reitsma P.H., Bertina R.M., and Rosendaal F.R. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 344 (1994) 1453-1457
45. Bertina R.M., Koeleman B.P., Koster T., Rosendaal F.R., Dirven R.J., de Ronde H., et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369 (1994) 64-67
46. Ma D.D., Aboud M.R., Williams B.G., and Isbister J.P. Activated protein c resistance (APC) and inherited factor V (FV) mis-sense mutation in patients with venous and arterial thrombosis in a haematology clinic. Aust N Z J Med 25 (1995) 151-154
47. Rao A.K., Sheth S., and Kaplan R. Inherited hypercoagulable states. Vasc Med 2 (1997) 313-320
48. Lensen R., Rosendaal F., Vandenbroucke J., and Bertina R. Factor V Leiden: the venous thrombotic risk in thrombophilic families. Br J Haematol 110 (2000) 939-945
49. Svensson P.J., Zoller B., Mattiasson I., and Dahlback B. The factor VR506Q mutation causing APC resistance is highly prevalent amongst unselected outpatients with clinically suspected deep venous thrombosis. J Intern Med 241 (1997) 379-385
50. Kyrle P.A., Mannhalter C., Beguin S., Stumpflen A., Hirschl M., Weltermann A., et al. Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene. Arterioscl Thromb Vasc Biol 18 (1998) 1287-1291
51. Hezard N., Bouaziz-Borgi L., Remy M.G., and Nguyen P. Utility of thrombin-generation assay in the screening of factor V G1691A (Leiden) and prothrombin G20210A mutations and protein S deficiency. Clin Chem 52 (2006) 665-670
52. Wahlander K., Larson G., Lindahl T.L., Andersson C., Frison L., Gustafsson D., et al. Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery. Thromb Haemost 87 (2002) 580-585