Factor V Leiden: The venous thrombotic risk in thrombophilic families

British Journal of Haematology

Volumn 110, Issue 4, 2000, Pages 939-945

  Lensen, Ruud ^a   Rosendaal, Frits ^a   Vandenbroucke, Jan ^a   Bertina, Rogier ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Activated protein C resistance; Factor V Leiden; Hypercoagulability; Thrombophilia; Venous thromboembolism

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN;

ADULT; ARTICLE; DISEASE ASSOCIATION; FAMILY HISTORY; FEMALE; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; THROMBOPHILIA; VEIN THROMBOSIS;

ADULT; AGE FACTORS; DISEASE-FREE SURVIVAL; FACTOR V; FEMALE; FOLLOW-UP STUDIES; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREVALENCE; PROTHROMBIN; RECURRENCE; RETROSPECTIVE STUDIES; RISK; VENOUS THROMBOSIS;

EID: 0033760132     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02236.x     Document Type: Article

References (35)

1. Familial venous thrombophilia
2. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect
3. Survival in families with hereditary protein C deficiency, 1820-1993
4. Mutation in blood coagulation factor V associated with resistance to activated protein C
5. The family history and inherited thrombophilia
6. Inherited thrombophilia: Resistance to activated protein C as a pathogenic factor of venous thromboembolism
7. Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C
8. Laboratory diagnosis of APC-resistance: A critical evaluation of the test and the development of diagnostic criteria
9. Activated protein C resistance causes by Arg 506 Gln mutation in factor Va
10. Anticoagulant protein C pathway defective in majority of thrombophilia patients
11. Mortality and causes of death in families with the factor V Leiden mutation (resistance to activated protein C)
12. Epidemiology and pathogenesis of venous thrombosis
13. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study
14. Inherited thrombophilia: Part 1 and 2
15. Apparent different thrombotic tendency in patients with Factor V Leiden and Protein C deficiency due to selection of patients
16. Venous thrombotic risk in family members of unselected individuals with factor V Leiden
17. Mutant factor V (Arg506Gln) in healthy centenarians
18. The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis
19. Hypercoagulable states
20. A prospective study of the incidence of deep-vein thrombosis within a defined urban population
21. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
22. Long-term outcomes after deep vein thrombosis of the lower extremities
23. World distribution of factor V Leiden
24. Factor V Leiden and risks of recurrent idiopathic venous thromboembolism
25. Thrombosis in the young: Epidemiology and risk factors. A focus on venous thrombosis
26. Mortality in hereditary antithrombin-III deficiency - 1830-1989
27. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)
28. The risk of recurrent venous thromboembolism in patients with an Arg506Gln mutation in the gene for factor V
29. Incidence of venous thromboembolism in families with inherited thrombophilia
30. Resistance to activated protein C as a basis for venous thrombosis
31. Hereditary antithrombin deficiency. Heterogeneity of the molecular basis and mortality in Dutch families
32. 506 (of) factor V
33. A single genetic origin for a common Caucasian risk factor for venous thrombosis
34. Identification of the same factor V gene mutation in 47 of 50 thrombosis-prone families with inherited resistance to activated protein C