New cytotoxic rosamine derivatives selectively accumulate in the mitochondria of cancer cells

Anti-Cancer Drugs

Volumn 20, Issue 6, 2009, Pages 461-468

  Siang, Hui Lim ^a   Wu, Liangxing ^b   Burgess, Kevin ^b   Hong, Boon Lee ^a  

^a CANCER RESEARCH INITIATIVES FOUNDATION   (Malaysia)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Accumulation in mitochondria; Cytotoxic rosamines; Lipophilic cations

Indexed keywords

CYTOTOXIC AGENT; RHODAMINE 123; ROSAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRAIN HL 60; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG POTENCY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; MITOCHONDRION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHENES;

EID: 67249113081     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32832b7bee     Document Type: Article

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