Anticarcinoma activity of a novel drug, 3-ethyl-3'-methyl- thiatelluracarbocyanine iodide (Te), a tellurium-containing cyanine targeted at mitochondria

Clinical Cancer Research

Volumn 2, Issue 8, 1996, Pages 1335-1340

  Sun, Xiaocheng ^a   Wong, James R ^b   Song, Kaili ^a   Chen, Lan Bo ^c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ETHYL 3' METHYLTHIATELLURACARBOCYANINE IODIDE; CARBOCYANINE; TELLURIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER LOCALIZATION; CARCINOMA CELL; CLONOGENIC ASSAY; EPITHELIUM CELL; IMPLANTATION; LIPOPHILICITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MONKEY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, NUDE; MITOCHONDRIA; NEOPLASMS, EXPERIMENTAL; ORGANOMETALLIC COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0029757652     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Summerhayes. I. C., Lampidis, T. J., Bernai, S. D., Nadakavukaren, J. J., Nadakavukaren, K. K., Shepherd, E. L., and Chen, L. B. Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells. Proc. Natl. Acad. Sci. USA, 79: 5292-5296, 1982.
2. Bernai, S. D., Lampidis, T. J., Summerhayes, I. C., and Chen, L. B. Rhodamine 123 selectively reduces clonal growth of carcinoma cells in vitro. Science (Washington DC), 218: 1117-1119, 1982.
3. Bernal, S. D., Lampidis, T. J., Mclsaac, R. M., and Chen, L. B. Anticarcinoma activity in vivo of rhodamine 123, a rnitochondrialspecific dye. Science (Washington DC), 222: 169-172, 1983.
4. Sun, X. C., Wong, J. R., Song, K., Hu, J., Garlid, K. D., and Chen L. B. AA1, a newly synthesized monovalent lipophilic cation, expresses potent in vivo antitumor activity. Cancer Res., 54: 1465-1471, 1994.
5. Oseroff, A. R., Ohuoha, D., Ara, G., McAulieffe, D., Foley, J., and Cincotta, L. Intramitochondrial dyes allow selective in vitro photolysis of carcinoma cells. Proc. Natl. Acad. Sci. USA, 83: 7929-7933, 1986.
6. Weiss. M. J., Wong. J. R., Ha, C. S., Bleday, R., Salem. R. R.. Steel, G. D . and Chen, L. B. Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation. Proc Natl, Acad. Sci. USA, 84: 5444-5448, 1987.
7. Wong, J. R , and Chen, L. B. Recent advances in the study of mitochondria in living cells. Adv. Cell Biol., 2. 263-290, 1988.
8. Modica-Napolitano, J. S.. Joyal, J. L., Ara, G., Oseroff, A. R., and Aprille. J. R. Mitochondrial toxicity of cationic photosensitizers for photochemotherapy. Cancer Res., 50: 7876-7881, 1990.
9. Rideout, D G., Calogeropooulou, T., Jaworski, J. S., Dagnino, R., Jr., and McCarthy, M. R. Phosphonium salts exhibiting selective anticarcinoma activity in vitro. Anti-Cancer Drug Des., 4: 465-480. 1989.
10. Davis, S., Weiss, M. J., Wong, J. R., Lampidis, T. J., and Chen L. B. Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells. J. Biol. Chem., 260: 13844-13850, 1985.
11. Chen, L. B., Weiss, M. J., Davis, S., Bleday, R. S., Wong, J. R., Song, J , and Terasaki, M. Mitochondria in living cells: effects of growth factors and tumor promoters, alterations in carcinoma cells and targets for therapy. Cancer Cells (Cold Spring Harbor), 3: 433-443, 1986.
12. Bleday, R., Weiss, M. J., Salem, R. R., Wilson, R. E., Chen, L. B., and Steele, G., Jr. Inhibition to rat colon tumor isograft growth with dequalinium chloride. Arch. Surg., 121: 1271-1275, 1986.
13. Nadakavukaren, K. K., Nadakavukaren. J. J., and Chen, L. B. Increased rhodamine 123 uptake by carcinoma cells. Cancer Res., 45: 6093-6099, 1986.
14. Teicher, B. A., Holden, S. A., Jacobs. J. L., Abrams, M. J., and Jones, A. G. Intracellular distribution of a platinum-rhodamine 123 complex in cis-platinum sensitive and resistant human squamous carcinoma cell lines. J. Biol. Chem., 35: 3365-3369, 1986.
15. Lampidis, T. J., Salet, C., Mareno, G., and Chen, L. B. Comparative effects of the mitochondrial probe rhodamine 123 and related analogs on the function and viability of pulsating myocardial cells in culture. Agents Actions, 14: 751-757, 1984.
16. Emaus, R. K., Grunwald, R., and Lemasters, J. J., Rhodamine 123 as a probe of transmembrane potential in isolated rat liver mitochondria: spectral and metabolic properties. Biochim. Biophys. Acta, 850: 436-448, 1986.
17. Mai, M. S., and Allison, W. S. Inhibition of an oligomycin-sensitive ATPase by cationic dyes, some of which are atypical uncouplers of intact mitochondria. Arch. Biochem. Biophys., 221: 467-476. 1983.
18. Modica-Napolitano, J. S., Weiss, M. J., Chen, L. B., and Aprille, J. R., Rhodamine 123 inhibits bioenergetic functions in isolated rat liver mitochondria. Biochem. Biophys. Res. Commun., 118: 717-723, 1984.
19. Morita, T., Mori, M., Ikeda, F., and Tatibana, M. Transport of carbamyl phosphate synthetase I and ornithine transcarbamylase into mitochondria. J. Biol. Chem., 257: 10547-10550, 1982.
20. Lubin, I M., Wu, L N. Y., Wuthier, R. E., and Fisher, R. R., Rhodamine 123 inhibits import of rat liver mitochondrial transhydrogenase. Biochem. Biophys. Res. Commun., 144: 477-483, 1987.
21. Devita, V. T, Hellman, S., and Rosenberg, S. (eds.). Principle and Practice of Oncology, Ed. 3. Philadelphia: J. B. Lippincott Co., 1989.