Effects of combined bacille calmette-guérin and dehydroepiandrosterone treatment on established asthma in mice

Experimental Lung Research

Volumn 35, Issue 3, 2009, Pages 250-261

  Lin, Xiang Hua ^a   Choi, Inseon S ^b   Koh, Young Ah ^a   Cui, Yong ^a  

^a Chonnam National University   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

Asthma; BCG; Dehydroepiandrosterone; Hypersensitivity; Interferon ; Interleukin 5

Indexed keywords

ANDROGEN; BCG VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 5; OVALBUMIN; PRASTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BCG VACCINATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; EOSINOPHILIA; FEMALE; HYPERSENSITIVITY; IMMUNOGLOBULIN BLOOD LEVEL; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; SUPERNATANT; ANIMAL; BAGG ALBINO MOUSE; BIOLOGICAL THERAPY; CYTOLOGY; IMMUNITY; IMMUNOLOGY; METHODOLOGY; MULTIMODALITY CANCER THERAPY; MYCOBACTERIUM BOVIS; SEX DIFFERENCE; SPLEEN; TREATMENT OUTCOME;

ANIMALS; ASTHMA; BIOLOGICAL THERAPY; BRONCHOALVEOLAR LAVAGE FLUID; COMBINED MODALITY THERAPY; DEHYDROEPIANDROSTERONE; EOSINOPHILIA; FEMALE; IMMUNITY; MALE; MICE; MICE, INBRED BALB C; MYCOBACTERIUM BOVIS; SEX FACTORS; SPLEEN; TREATMENT OUTCOME;

EID: 67149143207     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.1080/01902140802626656     Document Type: Article

References (20)

1. Cameron L, Vercelli D: Synthesis and regulation of immunoglobulin E. In: Adkinson N F Jr, Yunginger JW, Busse WW, Bochner BS, Holgate ST, Simons FER, eds. Middleton's Allergy Principles & Practice, 6th ed. Philadelphia: Mosby; 2003;87-100.
2. Wang CC, Rook GA: Inhibition of an established allergic response to ovalbumin in BALB/c mice by killed Mycobacterium vaccae. Immunology. 1998;93:307-313.
3. Hopfenspirger MT, Agrawal DK: Airway hyperresponsiveness, late allergic response, and eosinophilia are reversed with mycobacterial antigens in ovalbumin-presensitized mice. J Immunol. 2002;168:2516-2522.
4. Zuany-Amorim C, Sawicka E, Manlius C, Le Moine A, Brunet LR, Kemeny DA, Bowen G, Rook G, Walker C: Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat Med. 2002;8:625-629.
5. Araghi-Niknam M, Zhang Z, Jiang S, Call O, Eskelson CD, Watson RR: Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirus. Pro Soc Exp Biol Med. 1997;216:386-391.
6. Cheng GF, Tseng J: Regulation of murine interleukin-10 production by dehydroepiandrosterone. J Interferon Cytokine Res. 2000;20:471-478.
7. Yu CK, Liu YH, Chen CL: Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice. J Microbiol Immunol Infect. 2002;35:199-202.
8. Cui Y, Choi IS, Koh YA, Lin XH, Cho YB, Won YH: Effects of combined BCG and DHEA treatment in preventing the development of asthma. Immunol Invest. 2008;37:191-202.
9. Ribeiro F, Lopes RP, Nunes CP, Maito F,Bonorino C, Bauer ME: Dehydroepiandrosterone sulphate enhances IgG and interferon-gamma production during immunization to tuberculosis in young but not aged mice. Biogerontology. 2007;8:209-220.
10. Malo JL, Chan Yeung M: Occupational asthma. In: Adkinson NF Jr, Yunginger JW, Busse WW, Bochner BS, Holgate ST, Simons FER, eds. Middleton's Allergy Principles & Practice, 6th ed. Philadelphia: Mosby; 2003;1333-1352.
11. Dunn PJ, Mahood CB, Speed JF, Jury DR: Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study. N Z Med J. 1984;97:805-808.
12. Williams GH, Dluhy RG: Disorders of the adrenal cortex. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, eds. Harrison's Principles of Internal Medicine, 15th ed. Toronto: McGraw-Hill; 2001;2084-2105.
13. Du C, Guan Q, Khalil MW, Sriram S: Stimulation of Th2 response by high doses of dehydroepiandrosterone in KLH-primed splenocytes. Exp Biol Med. 2001;226:1051-1060.
14. Barlan I, Bahceciler NN, Akdis M, Akdis CA: Bacillus Calmette- Guérin, Mycobacterium bovis, as an immunomodulator in atopic diseases. Immunol Allergy Clin N Am. 2006;26:365-377.
15. Kemp EB, Belshe RB, Hoft DF: Immune responses stimulated by percutaneous and intradermal bacille Calmette-Guérin. J Infect Dis. 1996;174:113-119.
16. Hernandez-Pando R, De La Luz Streber M, Orozco H, Arriaga K, Pavon L, Al-Nakhli SA, Rook GA: The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice. Immunology. 1998;95:234-241.
17. Romagnani S: Regulatory T cells: which role in the pathogenesis and treatment of allergic disorders? Allergy. 2006;61:3-14.
18. Verthelyi D, Klinman DM: Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo. Immunology. 2000;100:384-390.
19. Harada M, Magara-Koyanagi K, Watarai H, Nagata Y, Ishii Y, Kojo S, Horiguchi S, Okamoto Y, Nakayama T, Suzuki N, Yeh WC, Akira S, Kitamura H, Ohara O, Seino K, Taniguchi M: IL-21- induced Bεcell apoptosis mediated by natural killer T cells suppresses IgE responses. J Exp Med. 2006;203:2929-2937.
20. Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG, Gelfand EW. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med. 1997;156:766-775.