Effects of combined BCG and DHEA treatment in preventing the development of asthma

Immunological Investigations

Volumn 37, Issue 3, 2008, Pages 191-202

  Cui, Yong ^a,b   Choi, Inseon S ^a,b   Koh, Young Ah ^b   Lin, Xiang Hua ^a,b   Cho, Yong Bum ^a,b   Won, Young Ho ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Androgen; Asthma; BCG; Dehydroepiandrosterone; Prevention

Indexed keywords

BCG VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4; METHACHOLINE; OVALBUMIN; PRASTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; BRONCHUS HYPERREACTIVITY; COLONY FORMING UNIT; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG INHIBITION; DRUG MEGADOSE; DRUG POTENTIATION; EOSINOPHILIA; FEMALE; IMMUNOMODULATION; LOW DRUG DOSE; LUNG LAVAGE; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SPLEEN CELL; TREATMENT OUTCOME;

ANIMALS; ASTHMA; BRONCHIAL PROVOCATION TESTS; DEHYDROEPIANDROSTERONE; FEMALE; HUMANS; IMMUNOGLOBULIN E; INJECTIONS, SUBCUTANEOUS; INTERFERON-GAMMA; INTERLEUKIN-4; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; MYCOBACTERIUM BOVIS; OVALBUMIN; SEX FACTORS;

EID: 41849115928     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1080/08820130801967833     Document Type: Article

References (25)

1. Barlan, I., Bahceciler, N. N., Akdis, M., Akdis, C. A. (2006). Bacillus Calmette-Guerin, Mycobacterium bovis, as an immunomodulator in atopic diseases. Immunol. Allergy Clin. N. Am. 26:365-377.
2. Choi, I. S., Koh, Y. I. (2002). Therapeutic effects of BCG vaccination in adult asthmatic patients: a randomized, controlled trial. Ann. Allergy Asthma Immunol. 88:584-591.
3. Choi, I. S., Lin, X. H., Koh, Y. A., Koh, Y. I., Lee, H. C. (2005). Strain-dependent suppressive effects of BCG vaccination on asthmatic reactions in BALB/c mice. Ann. Allergy Asthma Immunol. 95:571-578.
4. Crosbie, D., Black, C., McIntyre, L., Royle, P. L., Thomas, S. (2007). Dehydroepiandrosterone for systemic lupus erythematosus. Cochrane Database Syst. Rev. CD005114.
5. Du, C., Guan, Q., Khalil, M. W., Sriram, S. (2001). Stimulation of Th2 response by high doses of dehydroepiandrosterone in KLH-primed splenocytes. Exp. Biol. Med. 226:1051-1060.
6. Dunn, P. J., Mahood, C. B., Speed, J. F., Jury, D. R. (1984). Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study. N. Z. Med. J. 97:805-808.
7. Erb, K. J., Holloway, J. W., Sobeck, A., Moll, H., Le Gros, G. (1998). Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia. J. Exp. Med. 187:561-569.
8. Feher, K. G., Koo, E., Feher, T. (1983). Adrenocortical function in bronchial asthma. Acta Medica Hungarica 40:125-131.
9. Haggerty, C. L., Ness, R. B., Kelsey, S., Waterer, G. W. (2003). The impact of estrogen and progesterone on asthma. Ann. Allergy Asthma Immunol. 90:284-291.
10. Hernandez-Pando, R., De La Luz Streber, M., Orozco, H., Arriaga, K., Pavon, L., Al-Nakhli, S. A., Rook, G. A. (1998). The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice. Immunology 95:234-241.
11. Herz, U., Gerhold, K., Gruber, C., Braun, A., Wahn, U., Renz, H., Paul, K. (1998). BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model. J. Allergy Clin. Immunol. 102:867-874.
12. Hopfenspirger, M. T., Agrawal, D. K. (2002). Airway hyperresponsiveness, late allergic response, and eosinophilia are reversed with mycobacterial antigens in ovalbumin-presensitized mice. J. Immunol. 168:2516-2522.
13. Kemp, E. B., Belshe, R. B., Hoft, D. F. (1996). Immune responses stimulated by percutaneous and intradermal bacille Calmette-Guerin. J. Infect. Dis. 174:113-119.
14. Meikle, A. W., Dorchuck, R. W., Araneo, B. A., Stringham, J. D., Evans, T. G., Spruance, S. L., Daynes, R. A. (1992). The presence of a dehydroepiandrosterone-specific receptor binding complex in murine T cells. J. Steroid Biochem. Mol. Biol. 42:293-304.
15. National Heart, Lung, and Blood Institute (2007). National asthma education and prevention program. Expert panel report 3: Guidelines for the diagnosis and management of asthma. NIH Pub. No. 07-4051.
16. Nestler, J. E. (1995). Introduction. DHEA: A coming of age. Ann. N.Y. Acad. Sci. 774:ix-xi.
17. Shirtcliffe, P. M., Easthope, S. E., Weatherall, M., Beasley, R. (2004). Effect of repeated intradermal injections of heat-inactivated Mycobacterium bovis bacillus Calmette-Guerin in adult asthma. Clin. Exp. Allergy 34:207-212.
18. Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C., Koga, Y. (1997). The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol. 159:1739-1745.
19. Tabata, N., Tagami, H., Terui, T. (1997). Dehydroepiandrosterone may be one of the regulators of cytokine production in atopic dermatitis. Arch. Dermatol. Res. 289:410-414.
20. Yu, C. K., Yang, B. C., Lei, H. Y., Chen, Y. C., Liu, Y. H., Chen, C. C., Liu, C. W. (1999). Attenuation of house dust mite Dermatophagoides farinae-induced airway allergic responses in mice by dehydroepiandrosterone is correlated with down-regulation of Th2 response. Clin. Exp. Allergy 29:414-422.
21. Yu, C. K., Liu, Y. H., Chen, C. L. (2002). Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice. J. Microbiol. Immunol. Infect. 35:199-202.
22. Verthelyi, D., Klinman, D. M. (2000). Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo. Immunology 100:384-390.
23. Wang, C. C., Rook, G. A. (1998). Inhibition of an established allergic response to ovalbumin in BALB/c mice by killed Mycobacterium vaccae. Immunology 93:307-313.
24. Williams, G. H., Dluhy, R. G. (2001). Disorders of the adrenal cortex. In: Braunwald, E., et al., Eds., Harrison's Principles of Internal Medicine. 15th ed. McGraw-Hill: Toronto, pp. 2084-2105.
25. Zuany-Amorim, C., Sawicka, E., Manlius, C., Le Moine, A., Brunet, L. R., Kemeny, D. M., Bowen, G., Rook, G., Walker, C. (2002). Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat. Med. 8:625-629.