Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats

Phytotherapy Research

Volumn 23, Issue 6, 2009, Pages 859-862

  Preissler, Thales ^a   Martins, Márcio Rodrigo ^b   Pardo Andreu, Gilberto L ^c   Pêgas Henriques, João Antônio ^a   Quevedo, João ^b   Delgado, Rene ^c   Roesler, Rafael ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^c Centro de Quimica Farmaceutica   (Cuba)

Author keywords

Behaviour; Mangifera indica; Memory; Phytotherapy; Vimang

Indexed keywords

MANGIFERA INDICA EXTRACT; UNCLASSIFIED DRUG; VIMANG; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; AVERSIVE BEHAVIOR; BRAIN FUNCTION; CONTROLLED STUDY; HABITUATION; LOCOMOTION; LONG TERM MEMORY; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; NONHUMAN; OPEN FIELD BEHAVIOR; RAT; SHORT TERM MEMORY; ANIMAL; ANIMAL BEHAVIOR; AVOIDANCE BEHAVIOR; CHEMISTRY; DRUG EFFECT; MANGO; MEMORY; MOTOR ACTIVITY; WISTAR RAT;

MANGIFERA INDICA; RATTUS;

ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; HABITUATION, PSYCHOPHYSIOLOGIC; MALE; MANGIFERA; MEMORY; MOTOR ACTIVITY; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 67149117114     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2713     Document Type: Article

References (28)

1. Beltran AE, Alvarez Y, Xavier FE et al. 2004. Vascular effects of the Mangifera indica L. extract (Vimang). Eur J Pharmacol 499: 297-305. (Pubitemid 39233669)
2. Garcia D, Delgado R, Ubeira FM, Leiro J. 2002. Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin. Int Immunopharmacol 2: 797-806. (Pubitemid 34603124)
3. Garcia D, Escalante M, Delgado R, Ubeira FM, Leiro J. 2003a. Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin. Phytother Res 17: 1203-1208. (Pubitemid 38057180)
4. Garcia D, Leiro J, Delgado R, Sanmartin ML, Ubeira FM. 2003b. Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses. Phytother Res 17: 1182-1187. (Pubitemid 38057176)
5. Garrido G, Blanco-Molina M, Sancho R, Macho A, Delgado R, Munoz E. 2005. An aqueous stem bark extract of Mangifera indica (Vimang) inhibits T cell proliferation and TNF-induced activation of nuclear transcription factor NF-kappaB. Phytother Res 19: 211-215. (Pubitemid 40827644)
6. Garrido G, Delgado R, Lemus Y, Rodriguez J, Garcia D, Nunez-Selles AJ. 2004a. Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (Vimang). Role of mangiferin isolated from the extract. Pharmacol Res 50: 165-172.
7. Garrido G, Gonzalez D, Delporte C et al. 2001. Analgesic and anti-inflammatory effects of Mangifera indica L. extract (Vimang). Phytother Res 15: 18-21. (Pubitemid 32155103)
8. Garrido G, Gonzalez D, Lemus Y et al. 2004b. In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (Vimang). Pharmacol Res 50: 143-149.
9. Leiro J, Garcia D, Arranz JA, Delgado R, Sanmartin ML, Orallo F. 2004. An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophages. Int Immunopharmacol 4: 991-1003. (Pubitemid 38844174)
10. Martinez G, Delgado R, Perez G, Garrido G, Nunez Selles AJ, Leon OS. 2000. Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract (Vimang). Phytother Res 14: 424-427. (Pubitemid 30694579)
11. Martins MR, Reinke A, Valvassori SS et al. 2005. Non-associative learning and anxiety in rats treated with a single systemic administration of the gastrin-releasing peptide receptor antagonist RC-3095. Peptides 26: 2525-2529. (Pubitemid 41676727)
12. Nunez-Selles AJ, Delgado-Hernandez R, Garrido-Garrido G, Garcia-Rivera D, Guevara-Garcia M, Pardo-Andreu GL. 2007. The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract. Pharmacol Res 55: 351-358.
13. Nunez-Selles A, Vélez-Castro H, Agüero-Agüero J et al. 2002. Isolation and quantitative analysis of phenolic antioxidants, free sugars, fatty acids and polyols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as nutritional supplement. J Agric Food Chem 50: 762-766. (Pubitemid 34163620)
14. Pardo-Andreu GL, Barrios MF, Curti C et al. 2008a. Protective effects of Mangifera indica L extract (Vimang), and its major component mangiferin, on iron-induced oxidative damage to rats serum and liver. Pharmacol Res 57: 79-86.
15. Pardo-Andreu GL, Delgado R, Nunez-Selles AJ, Vercesi AE. 2006a. Mangifera indica L. extract (Vimang) inhibits 2-deoxyribose damage induced by Fe (III) plus ascorbate. Phytother Res 20: 120-124. (Pubitemid 43266836)
16. Pardo-Andreu GL, Delgado R, Núñez-Sellés AJ, Vercesi AE. 2006b. Dual mechanism of mangiferin protection against iron-induced damage to 2-deoxyribose and ascorbate oxidation. Pharmacol Res 53: 253-260. (Pubitemid 43247537)
17. 2+-citrate-induced lipoperoxidation in isolated rat liver mitochondria. Pharmacol Res 51: 427-435.
18. Pardo-Andreu G, Dorta DJ, Delgado R et al. 2006c. Vimang (Mangifera indica L. extract) induces permeability transition in isolated mitochondria, closely reproducing the effect of mangiferin, Vimang's main component. Chem Biol Interact 159: 141-148.
19. Pardo-Andreu GL, Paim BA, Castilho RF et al. 2008b. Mangifera indica L. extract (Vimang) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse. Pharmacol Res 57: 332-338.
20. Pardo-Andreu G, Philip SJ, Riano A et al. 2006d. Mangifera indica L. (Vimang) protection against serum oxidative stress in elderly humans. Arch Med Res 37: 158-164.
21. Pardo-Andreu GL, Sánchez-Baldoquín C, Ávila- González R et al. 2006e. Interaction of Vimang (Mangifera indica L. extract) with Fe(III) improves its antioxidant and cytoprotecting activity. Pharmacol Res 54: 389-395.
22. Picada JN, Schroder N, Izquierdo I, Henriques JA, Roesler R. 2002. Differential neurobehavioral deficits induced by apomorphine and its oxidation product, 8-oxo-apomorphine-semiquinone, in rats. Eur J Pharmacol 443: 105-111. (Pubitemid 34603604)
23. Quevedo J, Vianna MR, Martins MR et al. 2004. Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats. Behav Brain Res 154: 339-343. (Pubitemid 39093984)
24. Rivera DG, Balmaseda IH, Leon AA et al. 2006. Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin. J Pharm Pharmacol 58: 385-392.
25. Roesler R, Kopschina MI, Rosa RM, Henriques JA, Souza DO, Schwartsmann G. 2004. RC-3095, a bombesin/gastrin-releasing peptide receptor antagonist, impairs aversive but not recognition memory in rats. Eur J Pharmacol 486: 35-41. (Pubitemid 38130159)
26. Roesler R, Schroder N, Vianna MR et al. 2003. Differential involvement of hippocampal and amygdalar NMDA receptors in contextual and aversive aspects of inhibitory avoidance memory in rats. Brain Res 975: 207-213. (Pubitemid 36588568)
27. Sanchez GM, Re L, Giuliani A, Nunez-Selles AJ, Davison GP, Leon-Fernandez OS. 2000. Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol Res 42: 565-573. (Pubitemid 30948934)
28. Sanchez GM, Rodriguez HMA, Giuliani A et al. 2003. Protective effect of Mangifera indica L. extract (Vimang) on the injury associated with hepatic ischaemia reperfusion. Phytother Res 17: 197-201. (Pubitemid 36406746)