Dual mechanism of mangiferin protection against iron-induced damage to 2-deoxyribose and ascorbate oxidation

Pharmacological Research

Volumn 53, Issue 3, 2006, Pages 253-260

  Pardo Andreu, Gilberto Lázaro ^a,b   Delgado, René ^c   Núñez Sellés, Alberto J ^c   Vercesi, Anibal E ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSIDAD DE CAMAGÜEY   (Cuba)

^c Centro de Quimica Farmaceutica   (Cuba)

Author keywords

2 Deoxyribose; Ascorbate; Iron chelation; Mangiferin

Indexed keywords

2 DEOXYRIBOSE; ASCORBIC ACID; CITRIC ACID; EDETIC ACID; FERRIC ION; FERROUS ION; HYDROXYL RADICAL; IRON; IRON CHELATING AGENT; MANGIFERIN; OXYGEN; OXYGEN RADICAL; SCAVENGER; ANTIOXIDANT; DEOXYRIBOSE; FE(III) EDTA; FE(III)-EDTA; FERRIC CITRATE; XANTHONE DERIVATIVE;

ARTICLE; AUTOOXIDATION; DEGRADATION; DRUG EFFICACY; DRUG MECHANISM; IRON CHELATION; IRON OVERLOAD; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; CHEMICAL MODEL; CHEMISTRY; OXIDATION REDUCTION REACTION;

ANTIOXIDANTS; ASCORBIC ACID; DEOXYRIBOSE; EDETIC ACID; FERRIC COMPOUNDS; IRON CHELATING AGENTS; MODELS, CHEMICAL; OXIDATION-REDUCTION; XANTHONES;

EID: 32644464082     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2005.06.006     Document Type: Article

References (29)

1. I. Fridovich Oxygen toxicity: a radical explanation J Exp Biol 201 1998 1203 1209
2. J.S. Valentine, D.L. Wertz, T.J. Lyons, L.L. Liou, J.J. Goto, and E.B. Gralla The dark side of dioxygen biochemistry Curr Opin Chem Biol 2 1998 253 262
3. D.M. De Silva, C.C. Askwith, and J. Kaplan Molecular mechanisms of iron uptake in eukaryotes Physiol Rev 76 1996 31 47
4. R.S. Eisenstein, M.C. Kennedy, and H. Beinert The iron responsive element (IRE), the iron regulatory protein (IRP), and cytosolic aconitase. Post-transcriptional regulation of mammalian iron metabolism S. Silver W. Walden Metal Ions and Gene Regulation 1997 Chapman & Hall New York 157 216
5. S. Sheth, and G.M. Brittenham Genetic disorders affecting proteins of iron metabolism: clinical implications Annu Rev Med 51 2000 443 464
6. D.R. Richardson, and P. Ponka Pyridoxal isonicotinoyl hydrazone and its analogues: potential orally effective iron chelating agents for the treatment of iron overload diseases J Lab Clin Med 131 1998 306 314
7. M. Aritomi, and T. Kawasaki A new xanthone c-glucoside, position isomer of mangiferin, from Anemarrhena asphodeloides Bunge Tetrahedron Lett 12 1969 941 944
8. H. Ichiki, T. Miura, M. Kubo, E. Ishihara, Y. Komatsu, and K. Tanigawa New antidiabetic compounds, mangiferin and its glucoside Biol Pharm Bull 21 1998 1389 1390
9. S. Guha, S. Ghosal, and U. Chattopadhyay Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone Chemotherapy 42 1996 443 451
10. N. Yoshimi, K. Matsunaga, M. Katayama, Y. Yamada, T. Kuno, and Z. Qiao The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats Cancer Lett 163 2001 163 170
11. J. Leiro, J.A. Arranz, M. Yáñez, F.M. Ubeira, M.L. Sanmartín, and F. Orallo Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin Int Immunopharmacol 4 2004 763 778
12. T. Sato, A. Kawamoto, A. Tamura, Y. Tatsumi, and T. Fujii Mechanism of antioxidant action of pueraria glycoside (PG)-1 (an isoflavonoid) and mangiferin (a xanthonoid) Chem Pharm Bull 40 1992 721 724
13. 2+-citrate- induced lipoperoxidation in isolated rat liver mitochondria Pharmacol Res 51 2005 427 435
14. M. Yoshino, and K. Murakami Interaction of iron with polyphenolic compounds: application to antioxidant characterization Anal Biochem 257 1998 40 44
15. M. Hermes-Lima, P. Ponka, and M.H. Schulman The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate Biochim Biophys Acta 1523 2000 154 160
16. H.M. Schulman, M. Hermes-Lima, E.M. Wang, and P. Ponka In vitro antioxidant properties of the iron chelators pyridoxal isonicotinoyl hydrazone and some of its analogs Redox Rep 1 1995 373 378
17. 2+-citrate Eur J Pharmacol 513 2005 47 55
18. M.J. Zhao, and L. Jung Kinetics of the competitive degradation of the oxyribose and other molecules by hydroxyl radicals produced by the Fenton reaction in the presence of ascorbic acid Free Radic Res 23 1995 229 243
19. M. Roche, J. Desbarres, C. Colin, A. Hardy, and D. Bauer Collection Info Chimie, Technique et Documentation 1990 Lavoisier Paris
20. K.D. Welch, T.Z. Davies, and S.D. Aust Iron autoxidation and free radical generation: effects of buffer, ligands and chelators Arch Biochem Biophys 397 2002 360 369
21. A. Avdeef, S.R. Sofen, T.L. Bregante, and K.N. Raymond Coordination chemistry of microbial iron transport compounds. Stability constants for catechol models of enterobactin J Am Chem Soc 100 1978 5362 5370
22. J.B. Neilands Microbial iron transport compounds (sidrochromes) G. Eichorn Inorganic biochemistry 1973 Elsevier science Inc New York 167 202
23. M.Y. Moridani, J. Pourahmad, H. Bui, A. Siraki, and P.J. O'Brien Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers Free Radic Biol Med 34 2003 243 253
24. R.S. Britton, B.R. Bacon, and A.S. Tavill Mechanism of iron toxicity J.H. Brock J.W. Halliday M.J. Pippard L.W. Powell Iron metabolism in health and diseaes 1994 Saunders London 311 351
25. M. Grootveld, J.D. Bell, B. Halliwell, O.I. Aruoma, A. Bomford, and P.J. Sadler Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis J Biol Chem 264 1989 4417 4422
26. B. Halliwell, and J.M.C. Gutteridge Antioxidant defences B. Halliwell Gutteridge JMC Free radical in biology and medicine 3rd ed. 1999 Oxford University Press Oxford, UK 105 245
27. L. Lai, L.C. Lin, J.H. Lin, and T.H. Tsai Pharmacokinetic study of free mangiferin in rats by microdialysis coupled with microbore high-performance liquid chromatography and tandem mass spectrometry J Chromatogr A 987 2003 367 374
28. R. Dai, J. Gao, and K.J. Bi Determination of mangiferin, jateorrhizine, palmatine, berberine, cinnamic acid, and cinnamaldehyde in the traditional Chinese medicinal preparation Zi-Shen pill by high-performance liquid chromatography J Chromatogr Sci 42 2004 88 90
29. B. Halliwell Drug antioxidant effects. A basis for drug selection? Drugs 42 1991 569 605