Astragalus membranaceus prevents daunorubicin-induced apoptosis of cultured neonatal cardiomyocytes: Role of free radical effect of Astragalus membranaceus on daunorubicin cardiotoxicity

Phytotherapy Research

Volumn 23, Issue 6, 2009, Pages 761-767

  Luo, ZhongGuang ^a   Zhong, Lu ^b   Han, XiaoFeng ^c   Wang, HaiRong ^c   Zhong, JiHua ^c   Xuan, ZhengHua ^c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c NONE

Author keywords

Animal; Apoptosis; Astragalus membranaceus; Cardiomyocyte; Daunorubicin; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ASTRAGALUS MEMBRANACEUS EXTRACT; DAUNORUBICIN; DICHLOROFLUORESCEIN; HOE 33342; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ANTINEOPLASTIC ANTIBIOTIC; ANTIOXIDANT; HERBACEOUS AGENT;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CELL ACTIVITY; CELL DAMAGE; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DRUG EFFECT; DRUG MECHANISM; ENZYME RELEASE; FLOW CYTOMETRY; HEART CELL CULTURE; HEART MITOCHONDRION; HEART MUSCLE CELL; NEWBORN; NONHUMAN; RAT; ANIMAL; ASTRAGALUS MEMBRANACEUS; CELL CULTURE; CHEMISTRY; METABOLISM; MITOCHONDRION; SPRAGUE DAWLEY RAT;

ANIMALIA; ASTRAGALUS MEMBRANACEUS;

ACETYLCYSTEINE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; ASTRAGALUS MEMBRANACEUS; CELLS, CULTURED; DAUNORUBICIN; DRUGS, CHINESE HERBAL; L-LACTATE DEHYDROGENASE; MITOCHONDRIA; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 67149096651     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2575     Document Type: Article

References (28)

1. Abe K, Matsuki N. 2000. Measurement of cellular 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT. Neurosci Res 38: 325-329. (Pubitemid 32063338)
2. Chen XJ, Bian ZP, Lu S et al. 2006. Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril. Am J Chin Med 34: 493-502. (Pubitemid 43740985)
3. Cole MP, Chaiswing L, Oberley TD et al. 2006. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res 69: 186-197. (Pubitemid 41814822)
4. Doroshow JH, Locker GY, Myers CE. 1980. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest 65: 128-135. (Pubitemid 10214339)
5. Gong Y, Wang Y, Chen F et al. 2000. Identification of the subcellular localization of daunorubicin in multidrug-resistant K562 cell line. Leuk Res 24: 769-774. (Pubitemid 30649697)
6. Green PS, Leeuwenburgh C. 2002. Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis. Biochim Biophys Acta 1588: 94-101.
7. Jayaraman S. 2005. Flow cytometric determination of mitochondrial membrane potential changes during apoptosis of T lymphocytic and pancreatic beta cell lines: comparison of tetramethylrhodamineethylester (TMRE), chloromethyl-X-rosamine (H2-CMX-Ros) and MitoTracker Red 580 (MTR580). J Immunol Methods 306: 68-79. (Pubitemid 41742215)
8. Johnson SA. 2006. Anthracycline-induced cardiotoxicity in adult hematologic malignancies. Semin Oncol 33: S22-S27. (Pubitemid 43866215)
9. Kang YJ, Sun X, Chen Y et al. 2002. Inhibition of doxorubicin chronic toxicity in catalase-overexpressing transgenic mouse hearts. Chem Res Toxicol 15: 1-6. (Pubitemid 34106083)
10. Karoui H, Hansert B, Sand PJ et al. 1997. Spin-trapping of free radicals formed during the oxidation of glutathione by tetramethylammonium peroxynitrite. Nitric Oxide 1: 346-358. (Pubitemid 28078121)
11. 2+ overload and mitochondrial death pathway in H9c2 cells. Eur J Pharmacol 525: 1-7.
12. Lipshultz SE, Rifai N, Dalton VM et al. 2004. The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med 351: 145-153. (Pubitemid 38886649)
13. Lobner D. 2000. Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? J Neurosci Methods 96: 147-152.
14. Luo HM, Dai RHLi Y. 1995. [Nuclear cardiology study on effective ingredients of Astragalus membranaceus in treating heart failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi 15: 707-709.
15. McKenna D, Hughes K, Jones K. 2002. Astragalus. Altern Ther Health Med 8: 34-40; quiz 41- 42, 124.
16. Minotti G, Menna P, Salvatorelli E et al. 2004. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56: 185-229. (Pubitemid 38720829)
17. Oz E, Erbas D, Surucu HS et al. 2006. Prevention of doxorubicin-induced cardiotoxicity by melatonin. Mol Cell Biochem 282: 31-37. (Pubitemid 43019460)
18. Sarvazyan N. 1996. Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes. Am J Physiol 271: H2079-H2085. (Pubitemid 126832254)
19. Sawyer DB, Fukazawa R, Arstall MA et al. 1999. Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. Circ Res 84: 257-265. (Pubitemid 29095566)
20. Simpson P, Savion S. 1982. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ Res 50: 101-116.
21. Swope VB, Supp AP, Schwemberger S et al. 2006. Increased expression of integrins and decreased apoptosis correlate with increased melanocyte retention in cultured skin substitutes. Pigment Cell Res 19: 424-433. (Pubitemid 44326404)
22. von Harsdorf R, Li PF, Dietz R. 1999. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 99: 2934-2941. (Pubitemid 29258983)
23. 2- and p53-dependent pathways. J Biol Chem 279: 25535-25543.
24. Yilmaz S, Atessahin A, Sahna E et al. 2006. Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology 218: 164-171. (Pubitemid 41821347)
25. Yu DH, Bao YM, Wei CL et al. 2005. Studies of chemical constituents and their antioxidant activities from Astragalus mongholicus Bunge. Biomed Environ Sci 18: 297-301. (Pubitemid 41736475)
26. Yuan L, Inoue S, Saito Y et al. 1993. An evaluation of the effects of cytokines on intracellular oxidative production in normal neutrophils by flow cytometry. Exp Cell Res 209: 375-381. (Pubitemid 24005324)
27. Zhang WD, Chen H, Zhang C et al. 2006. Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Med 72: 4-8. (Pubitemid 43241585)
28. Zhou Z, Kang YJ. 2000. Cellular and subcellular localization of catalase in the heart of transgenic mice. J Histochem Cytochem 48: 585-594. (Pubitemid 30233182)