A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia

Pharmacogenetics and Genomics

Volumn 19, Issue 5, 2009, Pages 325-329

  Nagele, Peter ^a,b   Zeugswetter, Barbara ^b   Eberle, Corinna ^c   Hüpfl, Michael ^b   Mittlböck, Martina ^d   Födinger, Manuela ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Anesthesiology Critical Care Medicine and Pain Therapy   (United States)

^c Clinical Institute of Medical   (Austria)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Anesthetic mechanism; Cobalamin; Folate; Folate cycle; Nitrous oxide; One carbon metabolism; Pharmacogenetics; Vitamin

Indexed keywords

HOMOCYSTEINE; METHIONINE SYNTHASE; NITROUS OXIDE; ANESTHETIC AGENT; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; METHIONINE SYNTHASE REDUCTASE;

ADULT; ARTICLE; CONTROLLED STUDY; ELECTIVE SURGERY; ENZYME ACTIVITY; ENZYME INACTIVATION; FEMALE; GENERAL ANESTHESIA; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; NORMAL HUMAN; OXIDATION; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; ADOLESCENT; ANESTHESIA; BLOOD; FOLLOW UP; GENE FREQUENCY; GENETIC LINKAGE; GENETICS; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY; POSTOPERATIVE COMPLICATION; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION;

ADOLESCENT; ADULT; ANESTHESIA; ANESTHETICS; FEMALE; FERREDOXIN-NADP REDUCTASE; FOLLOW-UP STUDIES; GENE FREQUENCY; HOMOCYSTEINE; HUMANS; LINKAGE (GENETICS); MALE; MIDDLE AGED; NITROUS OXIDE; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTOPERATIVE COMPLICATIONS; UP-REGULATION; YOUNG ADULT;

EID: 67149084349     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328328d54c     Document Type: Article

References (36)

1. Amess JA, Burman JF, Rees GM, Nancekievill DG, Mollin DL. Megaloblastic haemopoiesis in patients receiving nitrous oxide. Lancet 1978; 2:339-342.
2. Amos RJ, Hinds CJ, Amess JAL, Mollin DL. Incidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care. Lancet 1982; 320:835-839.
3. Flippo TS, Holder WD Jr. Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. Arch Surg 1993; 128:1391-1395.
4. Layzer RB. Myeloneuropathy after prolonged exposure to nitrous oxide. Lancet 1978; 2:1227-1230.
5. Deacon R, Lumb M, Perry J, Chanarin I, Minty B, Halsey MJ, Nunn JF. Selective inactivation of vitamin B12 in rats by nitrous oxide. Lancet 1978; 2:1023-1024.
6. Banks RGS, Henderson RJ, Pratt JM. Reactions of gases in solution. Part III. Some reactions of nitrous oxide with transition-metal complexes. J Chem Soc A 1968; 3:2886-2889.
7. Koblin DD, Waskell L, Watson JE, Stokstad EL, Eger EI 2nd. Nitrous oxide inactivates methionine synthetase in human liver. Anesth Analg 1982; 61:75-78.
8. Nunn JF, Sharer N, Royston D, Watts RW, Purkiss P, Worth HG. Serum methionine and hepatic enzyme activity in anaesthetists exposed to nitrous oxide. Br J Anaesth 1982; 54:593-597.
9. Badner NH, Drader K, Freeman D, Spence JD. The use of intraoperative nitrous oxide leads to postoperative increases in plasma homocysteine. Anesth Analg 1998; 87:711-713.
10. Christensen B, Ueland PM. Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export. J Pharmacol Exp Ther 1993; 267:1298-1303.
11. Culley DJ, Raghavan SV, Waly M, Baxter MG, Yukhananov R, Deth RC, Crosby G. Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats. Anesth Analg 2007; 105:83-88.
12. Kondo H, Osborne ML, Kolhouse JF, Binder MJ, Podell ER, Utley CS, et al. Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats. J Clin Invest 1981; 67:1270-1283.
13. Elmore CL, Wu X, Leclerc D, Watson ED, Bottiglieri T, Krupenko NI, et al. Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab 2007; 91:85-97.
14. Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, et al. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocysteinuria. Proc Natl Acad Sci U S A 1998; 95:3059-3064.
15. Olteanu H, Banerjee R. Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation. J Biol Chem 2001; 276: 35558-35563.
16. Olteanu H, Munson T, Banerjee R. Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry 2002; 41:13378-13385.
17. Nagele P, Zeugswetter B, Wiener C, Burger H, Hüpfl M, Mittlböck M, Födinger M. Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia. Anesthesiology 2008; 109:36-43.
18. American Society of human genetics/American College of medical genetics test and transfer Committee Working Group. Measurement and use of total plasma homocysteine. Am J Hum Genet 1998; 63: 1541-1543.
19. Feix A, Winkelmayer WC, Eberle C, Sunder-Plassmann G, Fodinger M. Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients. Atherosclerosis 2004; 174:43-48.
20. Deng L, Elmore CL, Lawrance AK, Matthews RG, Rozen R. Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice. Mol Genet Metab 2008; 94: 336-342.
21. Wilson A, Leclerc D, Rosenblatt DS, Gravel RA. Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism. Hum Mol Genet 1999; 8:2009-2016.
22. Gherasim C, Rosenblatt D, Banerjee R. Polymorphic background of methionine synthase reductase modulates the phenotype of a disease-causing mutation. Hum Mutat 2007; 28:1028-1033.
23. Ueland PM, Hustad S, Schneede J, Refsum H, Vollset SE. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 2001; 22:195-201.
24. De Bree A, Verschuren WMM, Kromhout D, Kluijtmans LAJ, Blom HJ. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev 2002; 54:599-618.
25. Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 1997; 277:1775-1781.
26. Lonn E. Homocysteine-lowering B vitamin therapy in cardiovascular prevention-wrong again? JAMA 2008; 299:2086-2087.
27. Albert CM, Cook NR, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, et al. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA 2008; 299:2027-2036.
28. The Heart Outcomes Prevention Evaluation Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006; 354:1567-1577.
29. Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006; 354:1578-1588.
30. Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004; 50:3-32.
31. Myles PS, Chan MT, Leslie K, Peyton P, Paech M, Forbes A. Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery. Br J Anaesth 2008; 100:780-786.
32. Myles PS, Chan MT, Kaye DM, McIlroy DR, Lau CW, Symons JA, Chen S. Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function. Anesthesiology 2008; 109:657-663.
33. Myles PS, Leslie K, Chan MT, Forbes A, Paech MJ, Peyton P, et al. Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial. Anesthesiology 2007; 107:221-231.
34. Myles PS, Chan MT, Forbes A, Leslie K, Paech M, Peyton P. Preoperative folate and homocysteine status in patients undergoing major surgery. Clin Nutr 2006; 25:736-745.
35. Jahn UR, Berendes E. Nitrous oxide-an outdated anaesthetic. Best Pract Res Clin Anaesthesiol 2005; 19:391-397.
36. Badner NH, Beattie WS, Freeman D, Spence JD. Nitrous oxide-induced increased homocysteine concentrations are associated with increased postoperative myocardial ischemia in patients undergoing carotid endarterectomy. Anesth Analg 2000; 91:1073-1079.