Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells

Experimental Hematology

Volumn 37, Issue 7, 2009, Pages

  Ugarte, Fernando ^a   Ryser, Martin ^a,b   Thieme, Sebastian ^a,b   Fierro, Fernando A ^a   Navratiel, Katrin ^a   Bornhäuser, Martin ^a,b   Brenner, Sebastian ^a,b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ALIZARIN RED S; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; FATTY ACID BINDING PROTEIN 4; JAGGED1; LENTIVIRUS VECTOR; NOTCH RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA;

ADIPOGENESIS; ADULT; ARTICLE; BONE; BONE DEVELOPMENT; BONE MARROW; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; KIDNEY; LIVER; MALE; MARKER GENE; MINERALIZATION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STROMA CELL; TRANSGENE;

EID: 67049173056     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2009.03.007     Document Type: Article

References (37)

1. Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
2. Bianco P., Robey P.G., and Simmons P.J. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2 (2008) 313-319
3. Caplan A.I. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 213 (2007) 341-347
4. Wilson A., and Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 6 (2006) 93-106
5. Calvi L.M., Adams G.B., Weibrecht K.W., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425 (2003) 841-846
6. Sacchetti B., Funari A., Michienzi S., et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131 (2007) 324-336
7. Gregory C.A., Ylostalo J., and Prockop D.J. Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate. Sci STKE (2005) 2005 e37
8. Nuttall M.E., and Gimble J.M. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 4 (2004) 290-294
9. Satija N.K., Gurudutta G.U., Sharma S., et al. Mesenchymal stem cells: molecular targets for tissue engineering. Stem Cells Dev 16 (2007) 7-23
10. Bray S.J. Notch signaling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7 (2006) 678-689
11. Vujovic S., Henderson S.R., Flanagan A.M., and Clements M.O. Inhibition of gamma-secretases alters both proliferation and differentiation of mesenchymal stem cells. Cell Prolif 40 (2007) 185-195
12. Tezuka K., Yasuda M., Watanabe N., et al. Stimulation of osteoblastic cell differentiation by Notch. J Bone Miner Res 17 (2002) 231-239
13. Nobta M., Tsukazaki T., Shibata Y., et al. Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling. J Biol Chem 280 (2005) 15842-15848
14. Shindo K., Kawashima N., Sakamoto K., et al. Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling. Exp Cell Res 290 (2003) 370-380
15. Sciaudone M., Gazzerro E., Priest L., Delany A.M., and Canalis E. Notch 1 impairs osteoblastic cell differentiation. Endocrinology 144 (2003) 5631-5639
16. Deregowski V., Gazzerro E., Priest L., Rydziel S., and Canalis E. Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. J Biol Chem 281 (2006) 6203-6210
17. Zamurovic N., Cappellen D., Rohner D., and Susa M. Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity. J Biol Chem 279 (2004) 37704-37715
18. Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754
19. Komori T., Yagi H., Nomura S., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 (1997) 755-764
20. Engin F., Yao Z., Yang T., et al. Dimorphic effects of Notch signaling in bone homeostasis. Nat Med 14 (2008) 299-305
21. Hilton M.J., Tu X., Wu X., et al. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 14 (2008) 306-314
22. Rosen E.D., and MacDougald O.A. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7 (2006) 885-896
23. Garces C., Ruiz-Hidalgo M.J., Font de M.J., et al. Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J Biol Chem 272 (1997) 29729-29734
24. Ross D.A., Rao P.K., and Kadesch T. Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. Mol Cell Biol 24 (2004) 3505-3513
25. Nichols A.M., Pan Y., Herreman A., et al. Notch pathway is dispensable for adipocyte specification. Genesis 40 (2004) 40-44
26. Leis H.J., Hulla W., Gruber R., et al. Phenotypic heterogeneity of osteoblast-like MC3T3-E1 cells: changes of bradykinin-induced prostaglandin E2 production during osteoblast maturation. J Bone Miner Res 12 (1997) 541-551
27. Leboy P.S. Regulating bone growth and development with bone morphogenetic proteins. Ann N Y Acad Sci 1068 (2006) 14-18
28. Diefenderfer D.L., Osyczka A.M., Reilly G.C., and Leboy P.S. BMP responsiveness in human mesenchymal stem cells. Connect Tissue Res 44 Suppl 1 (2003) 305-311
29. Friedman M.S., Long M.W., and Hankenson K.D. Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6. J Cell Biochem 98 (2006) 538-554
30. Osyczka A.M., and Leboy P.S. Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling. Endocrinology 146 (2005) 3428-3437
31. Maillard I., Weng A.P., Carpenter A.C., et al. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood 104 (2004) 1696-1702
32. Schambach A., Bohne J., Chandra S., et al. Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. Mol Ther 13 (2006) 391-400
33. Dull T., Zufferey R., Kelly M., et al. A third-generation lentivirus vector with a conditional packaging system. J Virol 72 (1998) 8463-8471
34. Lian J.B., Stein G.S., Stein J.L., and van Wijnen A.J. Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation. J Cell Biochem 30-31 Suppl (1998) 62-72
35. Ross D.A., and Kadesch T. Consequences of Notch-mediated induction of Jagged1. Exp Cell Res 296 (2004) 173-182
36. Oldershaw R.A., Tew S.R., Russell A.M., et al. Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis. Stem Cells 26 (2008) 666-674
37. Hong J.H., Hwang E.S., McManus M.T., et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309 (2005) 1074-1078