Effect of bone morphogenetic protein-12 gene transfer on posterior cruciate ligament healing in a rabbit model

American Journal of Sports Medicine

Volumn 37, Issue 3, 2009, Pages 599-609

  Ma, Yong ^a   Zhang, Xin ^a   Wang, Jian ^a   Liu, Ping ^a   Zhao, Liheng ^a   Zhou, Chunyan ^b   Ao, Yingfang ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Bone morphogenetic protein 12; Collagen; Heal; Posterior cruciate ligament

Indexed keywords

ADENOVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN 12; COLLAGEN; BONE MORPHOGENETIC PROTEIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BIOMECHANICS; CONTROLLED STUDY; ENERGY ABSORPTION; FEMALE; HISTOLOGY; JOINT STIFFNESS; KNEE CRUCIATE LIGAMENT; KNEE LIGAMENT INJURY; NONHUMAN; POSTERIOR CRUCIATE LIGAMENT INJURY; PRIORITY JOURNAL; RABBIT; TENSILE STRENGTH; TISSUE REPAIR; TREATMENT FAILURE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WEIGHT BEARING; ANALYSIS OF VARIANCE; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; GENE TRANSFER; GENETICS; INJURY; KNEE LIGAMENT; WOUND HEALING;

ANALYSIS OF VARIANCE; ANIMALS; BONE MORPHOGENETIC PROTEINS; COLLAGEN; GENE TRANSFER TECHNIQUES; POSTERIOR CRUCIATE LIGAMENT; RABBITS; TENSILE STRENGTH; WOUND HEALING;

EID: 67049162831     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546508325960     Document Type: Article

References (42)

1. Allen CR, Kaplan LD, Fluhme DJ, Harner CD. Posterior cruciate ligament injuries. Curr Opin Rheumatol. 2002;14:142-149.
2. Bispo RZ Jr, Kawano CT, Guedes AV. Chronic multiple knee ligament injuries: epidemiological analysis of more than one hundred cases. Clinics. 2008;63:3-8.
3. Boynton MD, Tietjens BR. Long-term follow-up of the untreated isolated posterior cruciate ligament-deficient knee. Am J Sports Med. 1996;24:306-310.
4. Bray RC, Leonard CA, Salo PT. Correlation of healing capacity with vascular response in the anterior cruciate and medial collateral ligaments of the rabbit. J Orthop Res. 2003;21:1118-1123.
5. Chen CH. Surgical treatment of posterior cruciate ligament injury. Chang Gung Med J. 2007;30:480-492.
6. Davis W, Moskowitz RW. Degenerative joint changes following posterior cruciate ligament section in the rabbit. Clin Orthop Relat Res. 1973;93:307-312.
7. Doillon CJ, Dunn MG, Bender E, Silver FH. Collagen fiber formation in repair tissue: development of strength and toughness. Coll Rel Res. 1985;5:481-492.
8. Eriksson E. Why are some PCL-ruptures almost symptom free and others have "giving-way" problems? Knee Surg Sports Traumatol Arthrosc. 2007;15:319.
9. Fanelli GC. Posterior cruciate ligament rehabilitation: how slow should we go? Arthroscopy. 2008;24:234-235.
10. Fischer S P, Fox JM, Del Pizzo W, Friedman MJ, Snyder SJ, Ferkel RD. Accuracy of diagnoses from magnetic resonance imaging of the knee: a multi-center analysis of one thousand and fourteen patients. J Bone Joint Surg Am. 1991;73:2-10.
11. Fowler PJ, Messieh SS. Isolated posterior cruciate ligament injuries in athletes. Am J Sports Med. 1987;15:553-557.
12. Frank C, McDonald D, Wilson J, Eyre D, Shrive N. Rabbit medial collateral ligament scar weakness is associated with decreased collagen pyridinoline crosslink density. J Orthop Res. 1995;13:157-165.
13. Frank CB, Bray RC, Hart DA, et al. Soft tissue healing. In: Fu F, Harner CD, Vince KG, eds. Knee Surgery. Baltimore: Williams & Wilkins; 1994:189-230.
14. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998;95:2509-2514.
15. Hefti FL, Kress A, Fasel J, Morscher EW. Healing of the transected anterior cruciate ligament in the rabbit. J Bone Joint Surg Am. 1991; 73:373-383.
16. Heron CW, Calvert PT. Three-dimensional gradient-echo MR imaging of the knee: comparison with arthroscopy in 100 patients. Radiology. 1992;183:839-844.
17. Hildebrand KA, Deie M, Allen CR, et al. Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury. J Orthop Res.1999;17:37-42.
18. Inada M, Katagiri T, Akiyama S, et al. Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not include their differentiation into osteoblasts. Biochem Biophys Res Commun. 1996;222:317-322.
19. Iwamoto J, Takeda T, Suda Y, Otani T, Matsumoto H. Conservative treatment of isolated posterior cruciate ligament injury in professional baseball players: a report of two cases. Knee. 2004;11:41-44.
20. Ju YJ, Tohyama H, Kondo E, et al. Effects of local administration of vascular endothelial growth factor on properties of the in situ frozen-thawed anterior cruciate ligament in rabbits. Am J Sports Med. 2006; 34:84-91.
21. Keller P, Shelbourne KD, McCarroll JR, Rettig AC. Nonoperatively treated isolated posterior cruciate ligament injuries. Am J Sports Med. 1993;21:132-136.
22. Kondo E, Yasuda K, Yamanaka M, Minami A, Tohyama H. Effects of administration of exogenous growth factors on biomechanical properties of the elongation-type anterior cruciate ligament injury with partial laceration. Am J Sports Med. 2005;33:188-196.
23. Li G, Papannagari R, Li M, et al. Effect of posterior cruciate ligament deficiency on in vivo translation and rotation of the knee during weightbearing flexion. Am J Sports Med. 2008;36:474-479.
24. Lou J, Tu Y, Burns M, Silva MJ, Manske P. BMP-12 gene transfer augmentation of lacerated tendon repair. J Orthop Res. 2001;19: 1199-1202.
25. Lou J, Tu Y, Ludwig FJ, Zhang J, Manske PR. Effect of bone mor-phogenetic protein-12 gene transfer on mesenchymal progenitor cells. Clin Orthop Relat Res. 1999;369:333-339.
26. Mustonen AO, Koivikko M P, Haapamaki VV, Kiuru MJ, Lamminen AE, Koskinen SK. Multidetector computed tomography in acute knee injuries: assessment of cruciate ligaments with magnetic resonance imaging correlation. Acta Radiol. 2007;48:104-111.
27. Ng GY, Oakes BW, McLean ID, Deacon OW, Lampard D. The long-term biomechanical and viscoelastic performance of repairing anterior cruciate ligament after hemitransection injury in a goat model. Am J Sports Med. 1996;24:109-117.
28. Obayashi K, Akamatsu H, Okano Y, Matsunaga K, Masaki H. Exogenous nitric oxide enhances the synthesis of type I collagen and heat shock protein 47 by normal human dermal fibroblasts. J Dermatol Sci. 2006;41:121-126.
29. Parry DA, Barnes GR, Craig AS. A comparison of the size distribution of collagen fibrils in connective tissues as a function of age and a possible relation between fibril size distribution and mechanical properties. Proc R Soc Lond. 1978;203:305-321.
30. Petrigliano FA, McAllister DR. Isolated posterior cruciate ligament injuries of the knee. Sports Med Arthrosc. 2006;14:206-212.
31. Polly DW Jr, Callaghan JJ, Sikes RA, McCabe JM, McMahon K, Savory CG. The accuracy of selective magnetic resonance imaging compared with the findings of arthroscopy of the knee. J Bone Joint Surg Am. 1988;70:192-198.
32. Roberts CC, Towers JD, Spangehl MJ, Carrino JA, Morrison WB. Advanced MR imaging of the cruciate ligaments. Radiol Clin North Am. 2007;45:1003-1016, vi-vii.
33. Schulz MS, Russe K, Weiler A, Eichhorn HJ, Strobel MJ. Epidemiology of posterior cruciate ligament injuries. Arch Orthop Trauma Surg. 2003;123:186-191.
34. Shelbourne KD, Jennings RW, Vahey TN. Magnetic resonance imaging of posterior cruciate ligament injuries. Am J Knee Surg. 1999;12:209-213.
35. Skyhar M, Warren R, Ortiz G, Schwartz E, Otis J. The effects of sectioning of the posterior cruciate ligament and the posterolateral complex on the articular contact pressure within the knee. J Bone Joint Surg Am. 1993;75:694-699.
36. Spindler K P, Murray MM, Devin C, Nanney LB, Davidson JM. The central ACL defect as a model for failure of intra-articular healing. J Orthop Res. 2006;24:401-406.
37. Torg J, Barton T, Pavlov H, Stine R. Natural history of the posterior cruciate ligament-deficient knee. Clin Orthop Relat Res. 1989;246: 208-216.
38. Wang J, Ao Y F. The effect of rupture and reconstruction of posterior cruciate ligament on the degeneration of articular cartilage in rabbit knee [in Chinese]. Zhonghua Wai Ke Za Zhi. 2005;43:1598-1601.
39. Weiler A, Peters G, Maurer J, Unterhauser FN, Sudkamp N P. Biomechanical properties and vascularity of an anterior cruciate ligament graft can be predicted by contrast-enhanced magnetic resonance imaging: a two-year study in sheep. Am J Sports Med. 2001; 29:751-761.
40. Wind WM Jr, Bergfeld JA, Parker RD. Evaluation and treatment of posterior cruciate ligament injuries: revisited. Am J Sports Med. 2004;32:1765-1775.
41. Wolfman NM, Celeste AJ, Cox K, et al. Preliminary characterization of the biological activities of rhBMP-12. J Bone Miner Res. 1995;10: 148-153.
42. Wolfman NM, Hattersley G, Cox K, et al. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6 and 7 members of the TGF-beta gene family. J Clin Invest. 1997; 100:321-330.