Foxc2 transcription factor as a regulator of angiogenesis via induction of integrin β3 expression

Cell Adhesion and Migration

Volumn 3, Issue 1, 2009, Pages 24-26

  Hayashi, Hisaki ^a   Kume, Tsutomu ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Blood vessel; Endothelial cell migration; Foxc; Integrin; VEGF

Indexed keywords

BETA3 INTEGRIN; CD51 ANTIGEN; FIBRONECTIN; TRANSCRIPTION FACTOR FOXC2; VITRONECTIN;

ALPHA CHAIN; ANGIOGENESIS; BETA CHAIN; CANCER THERAPY; CELL ADHESION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; NOTE; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; TUMOR CELL; VASCULARIZATION;

EID: 67049156259     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.3.1.7252     Document Type: Note

References (30)

1. Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438:932-936 (Pubitemid 43093958)
2. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer 2008; 8:604-617
3. Serini G, Valdembri D, Bussolino F. Integrins and angiogenesis: a sticky business. Exp Cell Res 2006; 312:651-658 (Pubitemid 43290341)
4. Silva R, D'Amico G, Hodivala-Dilke KM, Reynolds LE. Integrins. The Keys to Unlocking Angiogenesis. Arterioscler Thromb Vasc Biol 2008; 28:1703-1713
5. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alphavbeta3 for angiogenesis. Science 1994; 264:569-571
6. Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, et al. Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaVbeta3 integrin. Cancer Cell 2003; 3:589-601. (Pubitemid 36808653)
7. Max R, Gerritsen RR, Nooijen PT, Goodman SL, Sutter A, Keilholz U, et al. Immunohistochemical analysis of integrin alphavbeta3 expression on tumor-associated vessels of human carcinomas. Int J Cancer 1997; 71:320-324 (Pubitemid 27224290)
8. Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Cullere M, et al. Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest 1999; 103:229-238 (Pubitemid 29053141)
9. Huang X, Griffiths M, Wu J, Farese RV Jr, Sheppard D. Normal development, wound healing and adenovirus susceptibility in beta5-deficient mice. Mol Cell Biol 2000; 20:755-759 (Pubitemid 30044211)
10. Weis SM, Lindquist JN, Barnes LA, Lutu-Fuga KM, Cui J, Wood MR, et al. Cooperation between VEGF and beta3 integrin during cardiac vascular development. Blood 2007; 109:1962-1970 (Pubitemid 46348193)
11. Reynolds AR, Reynolds LE, Nagel TE, Lively JC, Robinson SD, Hicklin DJ, et al. Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice. Cancer Res 2004; 64:8643-8650 (Pubitemid 39552078)
12. Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, et al. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 2002; 8:27-34.
13. Mahabeleshwar GH, Feng W, Phillips DR, Byzova TV. Integrin signaling is critical for pathological angiogenesis. J Exp Med 2006; 203:2495-2507 (Pubitemid 44664619)
14. Hayashi H, Sano H, Seo S, Kume T. The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression. J Biol Chem 2008; 283:23791-23800
15. Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T. The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol 2006; 294:458-470 (Pubitemid 43884821)
16. Hayashi H, Kume T. Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells. PLoS ONE 2008; 3:2401.
17. Kume T, Jiang H, Topczewska JM, Hogan BL. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev 2001; 15:2470-2482 (Pubitemid 32899749)
18. Malin D, Kim IM, Boetticher E, Kalin TV, Ramakrishna S, Meliton L, et al. Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol Cell Biol 2007; 27:2486-2498 (Pubitemid 46581341)
19. Odom DT, Dowell RD, Jacobsen ES, Gordon W, Danford TW, MacIsaac KD, et al. Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Genet 2007; 39:730-732 (Pubitemid 46848594)
20. Hayashi H, Kume T. Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration. Biochem Biophys Res Commun 2008; 367:584-589
21. Mahabeleshwar GH, Feng W, Reddy K, Plow EF, Byzova TV. Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res 2007; 101:570-580
22. Kerbel RS. Tumor angiogenesis. N Engl J Med 2008; 358:2039-2049
23. Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basallike breast cancers. Proc Natl Acad Sci USA 2007; 104:10069-10074 (Pubitemid 47175264)
24. Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW. Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. Gene Expr Patterns 2004; 4:611-619 (Pubitemid 39307524)
25. Kriederman BM, Myloyde TL, Witte MH, Dagenais SL, Witte CL, Rennels M, et al. FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome. Hum Mol Genet 2003; 12:1179-1185 (Pubitemid 36622150)
26. Petrova TV, Karpanen T, Norrmen C, Mellor R, Tamakoshi T, Finegold D, et al. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med 2004; 10:974-981 (Pubitemid 39273739)
27. Rutscher K, Wilting J. Transcription factor FOXC2 demarcates the jugular lymphangiogenic region in avian embryos. Lymphology 2008; 41:11-17
28. Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV Jr, et al. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol 2000; 20:5208-5215 (Pubitemid 30431573)
29. Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, et al. Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell 2007; 18:1421-1429 (Pubitemid 46626636)
30. Vlahakis NE, Young BA, Atakilit A, Sheppard D. The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. J Biol Chem 2005; 280:4544-4552 (Pubitemid 40288622)