Ketamine-induced gastroprotection during endotoxemia: Role of heme-oxygenase-1

Digestive Diseases and Sciences

Volumn 51, Issue 9, 2006, Pages 1571-1581

  Helmer, Kenneth S ^a   Suliburk, James W ^a   Mercer, David W ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

AP 1; Gastric injury; Heme oxygenase; HO 1; Lipopolysacharide; Mild irritants; NF ; Nitric oxide synthase

Indexed keywords

ALCOHOL; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KETAMINE; LIPOPOLYSACCHARIDE; PROTOPORPHYRIN TIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOWN REGULATION; DRUG EFFECT; ENDOTOXEMIA; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STOMACH INJURY; STOMACH MUCOSA; STOMACH PROTECTION; UPREGULATION;

ANALYSIS OF VARIANCE; ANESTHETICS, DISSOCIATIVE; ANIMALS; BLOTTING, WESTERN; ENDOTOXEMIA; ETHANOL; FEMALE; GASTRIC MUCOSA; HEME OXYGENASE-1; KETAMINE; LIPOPOLYSACCHARIDES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1;

EID: 33748588458     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-9013-0     Document Type: Article

References (59)

1. Tryba M (1991) Sucralfate versus antacids or H2-antagonists for stress ulcer prophylaxis: a meta-analysis on efficacy and pneumonia rate. Crit Care Med 19:942-949
2. Maier RV, Mitchell D, Gentilello L (1994) Optimal therapy for stress gastritis. Ann Surg 220:353-360 discussion 360-363
3. Cook DJ, Witt LG, Cook RJ, Guyatt GH (1991) Stress ulcer prophylaxis in the critically ill: a meta-analysis. Am J Med 91:519-527
4. Heyland D, Mandell LA (1992) Gastric colonization by gram-negative bacilli and nosocomial pneumonia in the intensive care unit patient. Evidence for causation. Chest 101:187-193
5. Garvey BM, McCambley JA, Tuxen DV (1989) Effects of gastric alkalization on bacterial colonization in critically ill patients. Crit Care Med 17:211-216
6. Mehall JR, Northrop R, Saltzman DA, Jackson RJ, Smith SD (2001) Acidification of formula reduces bacterial translocation and gut colonization in a neonatal rabbit model. J Pediatr Surg 36:56-62
7. Helmer KS, West SD, Vilela R, Chang L, Cui Y, Kone BC, Mercer DW (2004) Lipopolysaccharide-induced changes in rat gastric H/K-ATPase expression. Ann Surg 239:501-509
8. Mercer DW, Castaneda AA, Denning JW, Chang L, Russell DH (1998) Effects of endotoxin on gastric injury from luminal irritants in rats: potential roles of nitric oxide. Am J Physiol 275:G449-G459
9. Helmer KS, West SD, Shipley GL, Chang L, Cui Y, Mailman D, Mercer DW (2002) Gastric nitric oxide synthase expression during endotoxemia: implications in mucosal defense in rats. Gastroenterology 123:173-186
10. Stark ME, Szurszewski JH (1992) Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology 103:1928-1949
11. Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM, Harbrecht BG, Billiar TR (1997) Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide 1:404-416
12. Wu CC, Chen SJ, Szabo C, Thiemermann C, Vane JR (1995) Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. Br J Pharmacol 114:1666-1672
13. Helmer KS, Chang L, Cui Y, Mercer DW (2002) Induction of NF-kappaB, IkappaB-alpha, and iNOS in rat gastric mucosa during endotoxemia. J Surg Res 104:46-52
14. Guo JS, Cho CH, Wang WP, Shen XZ, Cheng CL, Koo MW (2003) Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats. World J Gastroenterol 9:1767-1771
15. Morse D, Choi AM (2002) Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol 27:8-16
16. Maines MD (1997) The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37:517-554
17. Becker JC, Grosser N, Boknik P, Schroder H, Domschke W, Pohle T (2003) Gastroprotection by vitamin C - A heme oxygenase-1-dependent mechanism? Biochem Biophys Res Commun 312:507-512
18. Larsen B, Hoff G, Wilhelm W, Buchinger H, Wanner GA, Bauer M (1998) Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood. Anesthesiology 89:1218-1227
19. Hoff G, Bauer I, Larsen B, Bauer M (2001) Modulation of endotoxin-stimulated TNF-alpha gene expression by ketamine and propofol in cultured human whole blood. Anaesthesist 50:494-499
20. Li CY, Chou TC, Wong CS, Ho ST, Wu CC, Yen MH, Ding YA (1997) Ketamine inhibits nitric oxide synthase in lipopolysaccharide-treated rat alveolar macrophages. Can J Anaesth 44:989-995
21. Sakai T, Ichiyama T, Whitten CW, Giesecke AH, Lipton JM (2000) Ketamine suppresses endotoxin-induced NF-kappaB expression. Can J Anaesth 47:1019-1024
22. Kawasaki T, Ogata M, Kawasaki C, Ogata J, Inoue Y, Shigematsu A (1999) Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg 89:665-669
23. Taniguchi T, Shibata K, Yamamoto K (2001) Ketamine inhibits endotoxin-induced shock in rats. Anesthesiology 95:928-932
24. Koga K, Ogata M, Takenaka I, Matsumoto T, Shigematsu A (1994) Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan-sensitized endotoxin shockmodel. Circ Shock 44:160-168
25. Bodai BI, Harms BA, Nottingham PB, Zaiss C, Demling RH (1983) The effect of ketamine on endotoxin-induced lung injury. Anesth Analg 62:398-403
26. Suliburk JW, Gonzalez EA, Kennison SD, Helmer KS, Mercer DW (2005) Differential effects of anesthetics on endotoxin-induced liver injury. J Trauma 58(4): 711-716
27. Wright M (1982) Pharmacologic effects of ketamine and its use in veterinary medicine. J Am Vet Med Assoc 180:1462-1471
28. Wright M (2003) Hypothermia protects against gut ischemia/reperfusion- induced impaired intestinal transit by inducing heme oxygenase-1. J Surg Res 115:48-55
29. Heid CA, Stevens J, Livak KJ, Williams PM (1996) Real time quantitative PCR. Genome Res 6:986-994
30. Wallace JL, Steel G, Whittle BJ, Lagente V, Vargaftig B (1987) Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists. Gastroenterology 93:765-773
31. Pritts TA, Moon MR, Wang Q, Hungness ES, Salzman AL, Fischer JE, Hasselgren PO (2000) Activation of NF-kappaB varies in different regions of the gastrointestinal tract during endotoxemia. Shock 14:118-122
32. Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649-683
33. Sun J, Wang XD, Liu H, Xu JG (2004) Ketamine suppresses intestinal NF-kappa B activation and proinflammatory cytokine in endotoxic rats. World J Gastroenterol 10:1028-1031
34. Minamoto K, Harada H, Lama VN, Fedarau MA, Pinsky DJ (2005) Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase. J Exp Med 202:283-294
35. Camhi SL, Alam J, Wiegand GW, Chin BY, Choi AM (1998) Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: role of reactive oxygen intermediates and AP-1. Am J Respir Cell Mol Biol 18:226-234
36. Camhi SL, Alam J, Otterbein L, Sylvester SL, Choi AM (1995) Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol 13:387-398
37. Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, Tysoe SA, Wolosker H, Baranano DE, Dore S, Poss KD, Snyder SH (1999) Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol 1:152-157
38. Hayashi S, Takamiya R, Yamaguchi T, Matsumoto K, Tojo SJ, Tamatani T, Kitajima M, Makino N, Ishimura Y, Suematsu M (1999) Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ Res 85:663-671
39. Nakagami T, Toyomura K, Kinoshita T, Morisawa S (1993) A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta 1158:189-193
40. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235:1043-1046
41. Bulotta S, Perrotta C, Cerullo A, De Palma C, Clementi E, Borgese N (2005) A cellular system to study the role of nitric oxide in cell death, survival, and migration. Neurotoxicology (in press)
42. Bishop A, Anderson JE (2005) NO signaling in the CNS: from the physiological to the pathological. Toxicology 208:193-205
43. Ferdinandy P, Schulz R (2003) Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 138:532-543
44. Potoka DA, Nadler EP, Upperman JS, Ford HR (2002) Role of nitric oxide and peroxynitrite in gut barrier failure. World J Surg 26:806-811
45. Torreilles J (2001) Nitric oxide: one of the more conserved and widespread signaling molecules. Front Biosci 6:D1161-D1172
46. Nishikawa Y, Stepp DW, Merkus D, Jones D, Chilian WM (2004) In vivo role of heme oxygenase in ischemic coronary vasodilation. Am J Physiol Heart Circ Physiol 286:H2296-H2304
47. Jozkowicz A, Huk I, Nigisch A, Weigel G, Dietrich W, Motterlini R, Dulak J (2003) Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX. Antioxid Redox Signal 5:155-162
48. Mingone CJ, Gupte SA, Quan S, Abraham NG, Wolin MS (2003) Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP. Exp Biol Med (Maywood) 228:535-539
49. Furchgott RF, Jothianandan D (1991) Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels 28:52-61
50. Brune B, Ullrich V (1987) Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol Pharmacol 32:497-504
51. McMillan K, Bredt DS, Hirsch DJ, Snyder SH, Clark JE, Masters BS (1992) Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide. Proc Natl Acad Sci USA 89:11141-11145
52. Stuehr DJ (1997) Structure-function aspects in the nitric oxide synthases. Annu Rev Pharmacol Toxicol 37:339-359
53. Srisook K, Cha YN (2005) Super-induction of HO-1 in macrophages stimulated with lipopolysaccharide by prior depletion of glutathione decreases iNOS expression and NO production. Nitric Oxide 12:70-79
54. Weiss G, Werner-Felmayer G, Werner ER, Grunewald K, Wachter H, Hentze MW (1994) Iron regulates nitric oxide synthase activity by controlling nuclear transcription. J Exp Med 180:969-976
55. Barton SG, Rampton DS, Winrow VR, Domizio P, Feakins RM (2003) Expression of heat shock protein 32 (hemoxygenase-1) in the normal and inflamed human stomach and colon: an immunohistochemical study. Cell Stress Chaperones 8:329-334
56. Brown JF, Tepperman BL, Hanson PJ, Whittle BJ (1994) Lipopolysaccharide induces Ca(2+)-independent nitric oxide synthase activity in rat gastric mucosal cells. Eur J Pharmacol 292:111-114
57. Ny L, Alm P, Larsson B, Andersson KE (1997) Morphological relations between haem oxygenases, NO-synthase and VIP in the canine and feline gastrointestinal tracts. J Auton Nerv Syst 65:49-56
58. Colpaert EE, Timmermans JP, Lefebvre RA (2002) Investigation of the potential modulatory effect of biliverdin, carbon monoxide and bilirubin on nitrergic neurotransmission in the pig gastric fundus. Eur J Pharmacol 457:177-186
59. Miller SM, Reed D, Sarr MG, Farrugia G, Szurszewski JH (2001) Haem oxygenase in enteric nervous system of human stomach and jejunum and co-localization with nitric oxide synthase. Neurogastroenterol Motil 13:121-131