Cell adhesion molecules in the central nervous system

Cell Adhesion and Migration

Volumn 3, Issue 1, 2009, Pages 29-35

  Togashi, Hideru ^a   Sakisaka, Toshiaki ^a   Takai, Yoshimi ^a,b  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Division of Cellular and Molecular Medicine   (Japan)

Author keywords

Axons; Cadherin superfamily; Cell adhesion molecules; Immunoglobulin superfamily; Nerve tissue proteins; Synapses

Indexed keywords

CADHERIN; CELL ADHESION MOLECULE; EPHRIN RECEPTOR; IMMUNOGLOBULIN; INTEGRIN; NECL 2 PROTEIN; NECTIN 1; NEUROLIGIN; PROTEIN DERIVATIVE; SYG 1 PROTEIN; SYG 2 PROTEIN; UNCLASSIFIED DRUG;

ASTROCYTE; CELL JUNCTION; CENTRAL NERVOUS SYSTEM; EPITHELIUM CELL; GLIA CELL; HUMAN; INTERNEURON; NERVE CELL PLASTICITY; NERVE FIBER; NONHUMAN; PROTEIN LOCALIZATION; REVIEW; SYNAPSE; SYNAPTIC TRANSMISSION;

EID: 67049137065     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.3.1.6773     Document Type: Review

References (80)

1. Sanes JR, Yamagata M. Formation of lamina-specific synaptic connections. Curr Opin Neurobiol 1999; 9:79-87. (Pubitemid 29084093)
2. Yamagata M, Sanes JR, Weiner JA. Synaptic adhesion molecules. Curr Opin Cell Biol 2003; 15:621-632 (Pubitemid 37176972)
3. Washbourne P, Dityatev A, Scheiffele P, Biederer T, Weiner JA, Christopherson KS, et al. Cell adhesion molecules in synapse formation. J Neurosci 2004; 24:9244-9249 (Pubitemid 39426160)
4. Tessier-Lavigne M, Goodman CS. The molecular biology of axon guidance. Science 1996; 274:1123-1133 (Pubitemid 26389268)
5. Scheiffele P. Cell-cell signaling during synapse formation in the CNS. Annu Rev Neurosci 2003; 26:485-508. (Pubitemid 37064942)
6. Fields RD, Stevens-Graham B. New insights into neuron-glia communication. Science 2002; 298:556-562
7. Spacek J, Lieberman AR. Three dimensional reconstruction in electron microscopy of the central nervous system. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove 1974; 17:203-222
8. Peters A, Palay SL, Webster HD. The fine structure of the nervous system: neurons and their supporting cells. New York: Oxford University Press 1991.
9. Uchida N, Honjo Y, Johnson KR, Wheelock MJ, Takeichi M. The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. J Cell Biol 1996; 135:767-779 (Pubitemid 26372931)
10. Mizoguchi A, Nakanishi H, Kimura K, Matsubara K, Ozaki-Kuroda K, Katata T, et al. Nectin: an adhesion molecule involved in formation of synapses. J Cell Biol 2002; 156:555-565 (Pubitemid 34839902)
11. Jontes JD, Smith SJ. Filopodia, spines and the generation of synaptic diversity. Neuron 2000; 27:11-14
12. Ziv NE, Garner CC. Cellular and molecular mechanisms of presynaptic assembly. Nat Rev Neurosci 2004; 5:385-399 (Pubitemid 38568499)
13. Takeichi M. The cadherin superfamily in neuronal connections and interactions. Nat Rev Neurosci 2007; 8:11-20. (Pubitemid 46011995)
14. Wheelock MJ, Johnson KR. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol 2003; 19:207-235 (Pubitemid 37487348)
15. Yamagata M, Herman JP, Sanes JR. Lamina-specific expression of adhesion molecules in developing chick optic tectum. J Neurosci 1995; 15:4556-4571
16. Fannon AM, Colman DR. A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins. Neuron 1996; 17:423-434 (Pubitemid 26322214)
17. Benson DL, Tanaka H. N-cadherin redistribution during synaptogenesis in hippocampal neurons. J Neurosci 1998; 18:6892-6904 (Pubitemid 28388019)
18. Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, Takeichi M. Cadherin regulates dendritic spine morphogenesis. Neuron 2002; 35:77-89. (Pubitemid 34804324)
19. Bozdagi O, Valcin M, Poskanzer K, Tanaka H, Benson DL. Temporally distinct demands for classic cadherins in synapse formation and maturation. Mol Cell Neurosci 2004; 27:509-521 (Pubitemid 39540004)
20. Scheiffele P, Fan J, Choih J, Fetter R, Serafini T. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 2000; 101:657-669
21. Bamji SX, Shimazu K, Kimes N, Huelsken J, Birchmeier W, Lu B, et al. Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 2003; 40:719-731 (Pubitemid 37431033)
22. Elia LP, Yamamoto M, Zang K, Reichardt LF. p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins. Neuron 2006; 51:43-56. (Pubitemid 43963333)
23. Suzuki SC, Inoue T, Kimura Y, Tanaka T, Takeichi M. Neuronal circuits are subdivided by differential expression of type-II classic cadherins in postnatal mouse brains. Mol Cell Neurosci 1997; 9:433-447 (Pubitemid 27467494)
24. Yagi T, Takeichi M. Cadherin superfamily genes: functions, genomic organization and neurologic diversity. Genes Dev 2000; 14:1169-1180 (Pubitemid 30327498)
25. Hirano S, Suzuki ST, Redies C. The cadherin superfamily in neural development: diversity, function and interaction with other molecules. Front Biosci 2003; 8:306-355 (Pubitemid 38943195)
26. Wu Q, Maniatis T. A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 1999; 97:779-790 (Pubitemid 29278051)
27. Weiner JA, Wang X, Tapia JC, Sanes JR. Gamma protocadherins are required for synaptic development in the spinal cord. Proc Natl Acad Sci USA 2005; 102:8-14. (Pubitemid 40094419)
28. Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, et al. Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron 2007; 56:456-471 (Pubitemid 350026265)
29. Takai Y, Nakanishi H. Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci 2003; 116:17-27. (Pubitemid 36113961)
30. Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P, Campadelli-Fiume G, et al. Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C′-C″-D beta-strands of the nectin1 V domain. J Biol Chem 2002; 277:27006-27013 (Pubitemid 34951712)
31. Yasumi M, Shimizu K, Honda T, Takeuchi M, Takai Y. Role of each immunoglobulin-like loop of nectin for its cell-cell adhesion activity. Biochem Biophys Res Commun 2003; 302:61-66 (Pubitemid 36268919)
32. Martinez-Rico C, Pincet F, Perez E, Thiery JP, Shimizu K, Takai Y, et al. Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3. J Biol Chem 2005; 280:4753-4760 (Pubitemid 40288646)
33. Tachibana K, Nakanishi H, Mandai K, Ozaki K, Ikeda W, Yamamoto Y, et al. Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J Cell Biol 2000; 150:1161-1176
34. Honda T, Shimizu K, Kawakatsu T, Yasumi M, Shingai T, Fukuhara A, et al. Antagonistic and agonistic effects of an extracellular fragment of nectin on formation of E-cadherin-based cell-cell adhesion. Genes Cells 2003; 8:51-63. (Pubitemid 36511693)
35. Suzuki K, Hu D, Bustos T, Zlotogora J, Richieri-Costa A, Helms JA, et al. Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palateectodermal dysplasia. Nat Genet 2000; 25:427-430 (Pubitemid 32983436)
36. Honda T, Sakisaka T, Yamada T, Kumazawa N, Hoshino T, Kajita M, et al. Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus. Mol Cell Neurosci 2006; 31:315-325 (Pubitemid 43214541)
37. Xie Z, Huganir RL, Penzes P. Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6. Neuron 2005; 48:605-618 (Pubitemid 41654682)
38. Togashi H, Miyoshi J, Honda T, Sakisaka T, Takai Y, Takeichi M. Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery. J Cell Biol 2006; 174:141-151 (Pubitemid 43992903)
39. Lim ST, Lim KC, Giuliano RE, Federoff HJ. Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. J Comp Neurol 2008; 507:1228-1244
40. Walsh FS, Doherty P. Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance. Annu Rev Cell Dev Biol 1997; 13:425-456 (Pubitemid 28034532)
41. Kiss JZ, Muller D. Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity. Rev Neurosci 2001; 12:297-310. (Pubitemid 33134328)
42. Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, et al. Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. J Neurosci 2004; 24:9372-9382 (Pubitemid 39426174)
43. Polo-Parada L, Bose CM, Landmesser LT. Alterations in transmission, vesicle dynamics and transmitter release machinery at NCAM-deficient neuromuscular junctions. Neuron 2001; 32:815-828 (Pubitemid 34024843)
44. Cremer H, Chazal G, Goridis C, Represa A. NCAM is essential for axonal growth and fasciculation in the hippocampus. Mol Cell Neurosci 1997; 8:323-335 (Pubitemid 127796472)
45. Seki T, Rutishauser U. Removal of polysialic acid-neural cell adhesion molecule induces aberrant mossy fiber innervation and ectopic synaptogenesis in the hippocampus. J Neurosci 1998; 18:3757-3766 (Pubitemid 28225683)
46. Monnier PP, Beck SG, Bolz J, Henke-Fahle S. The polysialic acid moiety of the neural cell adhesion molecule is involved in intraretinal guidance of retinal ganglion cell axons. Dev Biol 2001; 229:1-14. (Pubitemid 32061710)
47. Ango F, di Cristo G, Higashiyama H, Bennett V, Wu P, Huang ZJ. Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. Cell 2004; 119:257-272 (Pubitemid 39360907)
48. Shen K, Bargmann CI. The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans. Cell 2003; 112:619-630 (Pubitemid 36331775)
49. Shen K, Fetter RD, Bargmann CI. Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1. Cell 2004; 116:869-881 (Pubitemid 38410731)
50. Schneider T, Reiter C, Eule E, Bader B, Lichte B, Nie Z, et al. Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons. Neuron 1995; 15:259-271
51. Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, et al. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol 2001; 21:4829-4836 (Pubitemid 32588261)
52. Yamagata M, Weiner JA, Sanes JR. Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina. Cell 2002; 110:649-660 (Pubitemid 35247844)
53. Ushkaryov YA, Petrenko AG, Geppert M, Sudhof TC. Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Science 1992; 257:50-56
54. Missler M, Fernandez-Chacon R, Sudhof TC. The making of neurexins. J Neurochem 1998; 71:1339-1347 (Pubitemid 28443003)
55. Ichtchenko K, Hata Y, Nguyen T, Ullrich B, Missler M, Moomaw C, et al. Neuroligin 1: a splice site-specific ligand for beta-neurexins. Cell 1995; 81:435-443
56. Nguyen T, Sudhof TC. Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. J Biol Chem 1997; 272:26032-26039 (Pubitemid 27438933)
57. Graf ER, Zhang X, Jin SX, Linhoff MW, Craig AM. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 2004; 119:1013-1026 (Pubitemid 40037614)
58. Chih B, Engelman H, Scheiffele P. Control of excitatory and inhibitory synapse formation by neuroligins. Science 2005; 307:1324-1328 (Pubitemid 40299984)
59. Varoqueaux F, Aramuni G, Rawson RL, Mohrmann R, Missler M, Gottmann K, et al. Neuroligins determine synapse maturation and function. Neuron 2006; 51:741-754 (Pubitemid 44374915)
60. Sakisaka T, Takai Y. Biology and pathology of nectins and nectin-like molecules. Curr Opin Cell Biol 2004; 16:513-521 (Pubitemid 39201235)
61. Shingai T, Ikeda W, Kakunaga S, Morimoto K, Takekuni K, Itoh S, et al. Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem 2003; 278:35421-35427 (Pubitemid 37102311)
62. Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali ET, et al. SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 2002; 297:1525-1531 (Pubitemid 34970994)
63. Flanagan JG, Vanderhaeghen P. The Ephrins and Eph receptors in neural development. Annu Rev of Neurosci 1998; 21:309-345 (Pubitemid 28150666)
64. Dalva MB, Takasu MA, Lin MZ, Shamah SM, Hu L, Gale NW, et al. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell 2000; 103:945-956
65. Takasu MA, Dalva MB, Zigmond RE, Greenberg ME. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science 2002; 295:491-495 (Pubitemid 34101638)
66. Henkemeyer M, Itkis OS, Ngo M, Hickmott PW, Ethell IM. Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol 2003; 163:1313-1326 (Pubitemid 38032092)
67. Wolosker H, Blackshaw S, Snyder SH. Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci USA 1999; 96:13409-13414
68. Baranano DE, Ferris CD, Snyder SH. Atypical neural messengers. Trends Neurosci 2001; 24:99-106. (Pubitemid 32115440)
69. Mauch DH, Nagler K, Schumacher S, Goritz C, Muller EC, Otto A, Pfrieger FW. CNS synaptogenesis promoted by glia-derived cholesterol. Science 2001; 294:1354-1357 (Pubitemid 33063104)
70. Pfrieger FW, Barres BA. Synaptic efficacy enhanced by glial cells in vitro. Science 1997; 277:1684-1687 (Pubitemid 27446234)
71. Ullian EM, Sapperstein SK, Christopherson KS, Barres BA. Control of synapse number by glia. Science 2001; 291:657-661 (Pubitemid 32150425)
72. Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, et al. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell 2005; 120:421-433 (Pubitemid 40222435)
73. Hama H, Hara C, Yamaguchi K, Miyawaki A. PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes. Neuron 2004; 41:405-415 (Pubitemid 38221044)
74. Muller-Husmann G, Gloor S, Schachner M. Functional characterization of beta isoforms of murine Na,K-ATPase. The adhesion molecule on glia (AMOG/beta2), but not beta1, promotes neurite outgrowth. J Biol Chem 1993; 268:26260-26267 (Pubitemid 23361696)
75. Antonicek H, Persohn E, Schachner M. Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration. J Cell Biol 1987; 104:1587-1595 (Pubitemid 17104528)
76. Lecuona E, Luquin S, Avila J, Garcia-Segura LM, Martin-Vasallo P. Expression of the beta1 and beta2(AMOG) subunits of the Na,K-ATPase in neural tissues: cellular and developmental distribution patterns. Brain Res Bull 1996; 40:167-174 (Pubitemid 26166685)
77. Gloor S, Antonicek H, Sweadner KJ, Pagliusi S, Frank R, Moos M, Schachner M. The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,KATPase. J Cell Biol 1990; 110:165-174 (Pubitemid 120026826)
78. Pagliusi SR, Schachner M, Seeburg PH, Shivers BD. The Adhesion Molecule on Glia (AMOG) Is Widely Expressed by Astrocytes in Developing and Adult Mouse Brain. Eur J Neurosci 1990; 2:471-480 (Pubitemid 20170143)
79. Magyar JP, Bartsch U, Wang ZQ, Howells N, Aguzzi A, Wagner EF, et al. Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta2 subunit of murine Na,K-ATPase. J Cell Biol 1994; 127:835-845 (Pubitemid 24332977)
80. Kakunaga S, Ikeda W, Itoh S, Deguchi-Tawarada M, Ohtsuka T, Mizoguchi A, et al. Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J Cell Sci 2005; 118:1267-1277 (Pubitemid 40528696)