Evaluation, by a statistically designed experiment, of an experimental grade of microcrystalline cellulose, Avicel 955, as a technology to aid the production of pellets with high drug loading

Journal of Pharmaceutical Sciences

Volumn 85, Issue 7, 1996, Pages 700-705

  Jover, Isabel ^a   Podczeck, Fridrun ^a   Newton, Michael ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; AVICEL 955; BORIC ACID; CAFFEINE; CITRATE SODIUM; GLUCOSE; GLYCINE; IBUPROFEN; MANNITOL; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; POTASSIUM CHLORIDE; SALICYLAMIDE; SALICYLATE SODIUM; SODIUM CHLORIDE; SORBITOL; THEOPHYLLINE; UNCLASSIFIED DRUG; ZINC SULFATE;

ARTICLE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG GRANULATION; DRUG MANUFACTURE; DRUG QUALITY; DRUG SCREENING; DRUG SOLUBILITY; PKA; PREDICTION; TECHNICAL AID; WATER CONTENT;

EID: 0030017608     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js950524a     Document Type: Article

References (9)

1. Newton, J. M. In Powder Technology and Pharmaceutical Processes; Chulia, D., Deleuil, M., Pourcelot, Y., Eds.; Elsevier: Amsterdam, 1994; pp 391-401.
2. Podczeck, F. In Pharmaceutical Powder Compaction; Alderborn, G., Nyström, C., Eds.; Marcel Dekker Inc.: New York, 1995; pp 561-593.
3. Harrison, P. J.; Newton, J. M.; Rowe, R. C. J. Pharm. Pharmacol. 1985, 38, 689-691.
4. Fielden, K. E.; Newton, J. M.; Rowe, R. C. Int. J. Pharm. 1992, 81, 225-233.
5. Newton, J. M.; Chapman, S. R.; Rowe, R. C. Ibid. 1995, 120, 95-99.
6. Podczeck, F.; Newton, J. M. J. Pharm. Pharmacol. 1994, 46, 82-85.
7. Davies, L. Efficiency in Research, Development and Production: The Statistical Design and Analysis of Chemical Experiments; The Royal Society of Chemistry; Dorchester, 1993.
8. Flury, B.; Riedwyl, H. Angewandte multivariate Statistik; Gustav Fischer Verlag: Stuttgart, 1983; pp 112-134.
9. Hartung, J.; Elpelt, B. Multivariate Statistik; R. Oldenbourg Verlag München, 1984; pp 172-181.