메뉴 건너뛰기




Volumn 21, Issue 3, 2009, Pages 251-257

B cell acquisition of antigen in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C3D RECEPTOR; CXCL13 CHEMOKINE; FC RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; T LYMPHOCYTE ANTIGEN;

EID: 67049136155     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2009.05.013     Document Type: Review
Times cited : (37)

References (46)
  • 2
    • 0019231835 scopus 로고
    • The follicular dendritic cell: long term antigen retention during immunity
    • Mandel T.E., Phipps R.P., Abbot A., and Tew J.G. The follicular dendritic cell: long term antigen retention during immunity. Immunol Rev 53 (1980) 29-59
    • (1980) Immunol Rev , vol.53 , pp. 29-59
    • Mandel, T.E.1    Phipps, R.P.2    Abbot, A.3    Tew, J.G.4
  • 3
    • 0036840139 scopus 로고    scopus 로고
    • Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway
    • Gommerman J.L., Mackay F., Donskoy E., Meier W., Martin P., and Browning J.L. Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway. J Clin Invest 110 (2002) 1359-1369
    • (2002) J Clin Invest , vol.110 , pp. 1359-1369
    • Gommerman, J.L.1    Mackay, F.2    Donskoy, E.3    Meier, W.4    Martin, P.5    Browning, J.L.6
  • 4
    • 0030610087 scopus 로고    scopus 로고
    • Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses
    • Fu Y.X., Molina H., Matsumoto M., Huang G., Min J., and Chaplin D.D. Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses. J Exp Med 185 (1997) 2111-2120
    • (1997) J Exp Med , vol.185 , pp. 2111-2120
    • Fu, Y.X.1    Molina, H.2    Matsumoto, M.3    Huang, G.4    Min, J.5    Chaplin, D.D.6
  • 6
    • 30444457243 scopus 로고    scopus 로고
    • FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses
    • Victoratos P., Lagnel J., Tzima S., Alimzhanov M.B., Rajewsky K., Pasparakis M., and Kollias G. FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity 24 (2006) 65-77
    • (2006) Immunity , vol.24 , pp. 65-77
    • Victoratos, P.1    Lagnel, J.2    Tzima, S.3    Alimzhanov, M.B.4    Rajewsky, K.5    Pasparakis, M.6    Kollias, G.7
  • 7
    • 0032545987 scopus 로고    scopus 로고
    • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
    • Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., and Williams L.T. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 391 (1998) 799-803
    • (1998) Nature , vol.391 , pp. 799-803
    • Gunn, M.D.1    Ngo, V.N.2    Ansel, K.M.3    Ekland, E.H.4    Cyster, J.G.5    Williams, L.T.6
  • 9
    • 0032211091 scopus 로고    scopus 로고
    • Antibody production and B cell-FDC communication via CD21-CD21 ligand
    • Qin D., Wu J., Carroll M.C., Burton G.F., Szakal A.K., and Tew J.G. Antibody production and B cell-FDC communication via CD21-CD21 ligand. J Immunol 161 (1998) 4549-4554
    • (1998) J Immunol , vol.161 , pp. 4549-4554
    • Qin, D.1    Wu, J.2    Carroll, M.C.3    Burton, G.F.4    Szakal, A.K.5    Tew, J.G.6
  • 10
    • 0032521019 scopus 로고    scopus 로고
    • Local synthesis of C3 within the splenic lymphoid compartment can reconstitute the impaired immune response in C3-deficient mice
    • Fischer M.B., Ma M., Hsu N., and Carroll M.C. Local synthesis of C3 within the splenic lymphoid compartment can reconstitute the impaired immune response in C3-deficient mice. J Immunol 160 (1998) 2619-2625
    • (1998) J Immunol , vol.160 , pp. 2619-2625
    • Fischer, M.B.1    Ma, M.2    Hsu, N.3    Carroll, M.C.4
  • 14
    • 0025255536 scopus 로고
    • The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1
    • Kurtz C.B., O'Toole E., Christensen S.M., and Weis J.H. The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1. J Immunol 144 (1990) 3581-3591
    • (1990) J Immunol , vol.144 , pp. 3581-3591
    • Kurtz, C.B.1    O'Toole, E.2    Christensen, S.M.3    Weis, J.H.4
  • 15
    • 0028291667 scopus 로고
    • Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2
    • Molina H., Kinoshita T., Webster C.B., and Holers V.M. Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2. J Immunol 153 (1994) 789-795
    • (1994) J Immunol , vol.153 , pp. 789-795
    • Molina, H.1    Kinoshita, T.2    Webster, C.B.3    Holers, V.M.4
  • 16
    • 5444259851 scopus 로고    scopus 로고
    • The complement system in regulation of adaptive immunity
    • Carroll M.C. The complement system in regulation of adaptive immunity. Nat Immunol 5 (2004) 981-986
    • (2004) Nat Immunol , vol.5 , pp. 981-986
    • Carroll, M.C.1
  • 17
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature 381 (1996) 751-758
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 18
    • 0026845207 scopus 로고
    • Signals involved in germinal center reactions
    • Kosco M.H., and Gray D. Signals involved in germinal center reactions. Immunol Rev 126 (1992) 63-76
    • (1992) Immunol Rev , vol.126 , pp. 63-76
    • Kosco, M.H.1    Gray, D.2
  • 19
    • 0026033729 scopus 로고
    • Novel pathways of antigen presentation for the maintenance of memory
    • Gray D., Kosco M.H., and Stockinger B. Novel pathways of antigen presentation for the maintenance of memory. Int Immunol 3 (1991) 141-148
    • (1991) Int Immunol , vol.3 , pp. 141-148
    • Gray, D.1    Kosco, M.H.2    Stockinger, B.3
  • 20
    • 0036360020 scopus 로고    scopus 로고
    • A role for antigen in the maintenance of immunological memory
    • Gray D. A role for antigen in the maintenance of immunological memory. Nat Rev Immunol 2 (2002) 60-65
    • (2002) Nat Rev Immunol , vol.2 , pp. 60-65
    • Gray, D.1
  • 21
  • 22
    • 33745770407 scopus 로고    scopus 로고
    • Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells
    • Brockman M.A., Verschoor A., Zhu J., Carroll M.C., and Knipe D.M. Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells. J Virol 80 (2006) 7111-7117
    • (2006) J Virol , vol.80 , pp. 7111-7117
    • Brockman, M.A.1    Verschoor, A.2    Zhu, J.3    Carroll, M.C.4    Knipe, D.M.5
  • 23
    • 0034609775 scopus 로고    scopus 로고
    • Memory B cell persistece is independent of persisting immunizing antigen
    • Maruyama M., Lam K.-P., and Rajewsky K. Memory B cell persistece is independent of persisting immunizing antigen. Nature 407 (2000) 636-641
    • (2000) Nature , vol.407 , pp. 636-641
    • Maruyama, M.1    Lam, K.-P.2    Rajewsky, K.3
  • 24
    • 0034596892 scopus 로고    scopus 로고
    • Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells
    • Hannum L.G., Haberman A.M., Anderson S.M., and Shlomchik M.J. Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells. J Exp Med 192 (2000) 931-942
    • (2000) J Exp Med , vol.192 , pp. 931-942
    • Hannum, L.G.1    Haberman, A.M.2    Anderson, S.M.3    Shlomchik, M.J.4
  • 26
    • 0042422053 scopus 로고    scopus 로고
    • The B cell receptor itself can activate complement to provide the complement receptor 1/2 ligand required to enhance B cell immune responses in vivo
    • Rossbacher J., and Shlomchik M.J. The B cell receptor itself can activate complement to provide the complement receptor 1/2 ligand required to enhance B cell immune responses in vivo. J Exp Med 198 (2003) 591-602
    • (2003) J Exp Med , vol.198 , pp. 591-602
    • Rossbacher, J.1    Shlomchik, M.J.2
  • 27
    • 0037036142 scopus 로고    scopus 로고
    • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    • Miller M.J., Wei S.H., Parker I., and Cahalan M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296 (2002) 1869-1873
    • (2002) Science , vol.296 , pp. 1869-1873
    • Miller, M.J.1    Wei, S.H.2    Parker, I.3    Cahalan, M.D.4
  • 28
    • 0037418183 scopus 로고    scopus 로고
    • Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy
    • Miller M.J., Wei S.H., Cahalan M.D., and Parker I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci USA 100 (2003) 2604-2609
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2604-2609
    • Miller, M.J.1    Wei, S.H.2    Cahalan, M.D.3    Parker, I.4
  • 29
    • 35948935059 scopus 로고    scopus 로고
    • Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
    • Identification of CD168+ macrophages as important in the trapping of lymph-borne virus and presentation to cognante B cells.
    • Junt T., Moseman E.A., Iannacone M., Massberg S., Lang P.A., Boes M., Fink K., Henrickson S.E., Shayakhmetov D.M., Di Paolo N.C., et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450 (2007) 110-114. Identification of CD168+ macrophages as important in the trapping of lymph-borne virus and presentation to cognante B cells.
    • (2007) Nature , vol.450 , pp. 110-114
    • Junt, T.1    Moseman, E.A.2    Iannacone, M.3    Massberg, S.4    Lang, P.A.5    Boes, M.6    Fink, K.7    Henrickson, S.E.8    Shayakhmetov, D.M.9    Di Paolo, N.C.10
  • 30
    • 34447623566 scopus 로고    scopus 로고
    • B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
    • Characterization of cognate B cell uptake of particulate antigen from SCS macrophages.
    • Carrasco Y.R., and Batista F.D. B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity 27 (2007) 160-171. Characterization of cognate B cell uptake of particulate antigen from SCS macrophages.
    • (2007) Immunity , vol.27 , pp. 160-171
    • Carrasco, Y.R.1    Batista, F.D.2
  • 31
    • 34548044827 scopus 로고    scopus 로고
    • Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
    • First identification of a role for naïve B cells within peripheral LNS as carriers of IC from SCS macrophages into B cell follicles.
    • Phan T.G., Grigorova I., Okada T., and Cyster J.G. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol 8 (2007) 992-1000. First identification of a role for naïve B cells within peripheral LNS as carriers of IC from SCS macrophages into B cell follicles.
    • (2007) Nat Immunol , vol.8 , pp. 992-1000
    • Phan, T.G.1    Grigorova, I.2    Okada, T.3    Cyster, J.G.4
  • 32
    • 0029829528 scopus 로고    scopus 로고
    • Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers
    • Martinez-Pomares L., Kosco-Vilbois M., Darley E., Tree P., Herren S., Bonnefoy J.Y., and Gordon S. Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers. J Exp Med 184 (1996) 1927-1937
    • (1996) J Exp Med , vol.184 , pp. 1927-1937
    • Martinez-Pomares, L.1    Kosco-Vilbois, M.2    Darley, E.3    Tree, P.4    Herren, S.5    Bonnefoy, J.Y.6    Gordon, S.7
  • 33
    • 5044252309 scopus 로고    scopus 로고
    • Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells
    • Ferguson A.R., Youd M.E., and Corley R.B. Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells. Int Immunol 16 (2004) 1411-1422
    • (2004) Int Immunol , vol.16 , pp. 1411-1422
    • Ferguson, A.R.1    Youd, M.E.2    Corley, R.B.3
  • 34
    • 37349013401 scopus 로고    scopus 로고
    • Follicular shuttling of marginal zone B cells facilitates antigen transport
    • Report that MZ B cells shuttle between MZ and B cell follicles bearing complement-coated IC.
    • Cinamon G., Zachariah M.A., Lam O.M., Foss Jr. F.W., and Cyster J.G. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol 9 (2008) 54-62. Report that MZ B cells shuttle between MZ and B cell follicles bearing complement-coated IC.
    • (2008) Nat Immunol , vol.9 , pp. 54-62
    • Cinamon, G.1    Zachariah, M.A.2    Lam, O.M.3    Foss Jr., F.W.4    Cyster, J.G.5
  • 35
    • 0034232062 scopus 로고    scopus 로고
    • Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response
    • Guinamard R., Okigaki M., Schlessinger J., and Ravetch J.V. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol 1 (2000) 31-36
    • (2000) Nat Immunol , vol.1 , pp. 31-36
    • Guinamard, R.1    Okigaki, M.2    Schlessinger, J.3    Ravetch, J.V.4
  • 36
    • 0037220540 scopus 로고    scopus 로고
    • Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice
    • Pozdnyakova O., Guttormsen H.K., Lalani F.N., Carroll M.C., and Kasper D.L. Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice. J Immunol 170 (2003) 84-90
    • (2003) J Immunol , vol.170 , pp. 84-90
    • Pozdnyakova, O.1    Guttormsen, H.K.2    Lalani, F.N.3    Carroll, M.C.4    Kasper, D.L.5
  • 37
    • 34247149876 scopus 로고    scopus 로고
    • The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles
    • Pape K.A., Catron D.M., Itano A.A., and Jenkins M.K. The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Immunity 26 (2007) 491-502
    • (2007) Immunity , vol.26 , pp. 491-502
    • Pape, K.A.1    Catron, D.M.2    Itano, A.A.3    Jenkins, M.K.4
  • 38
    • 60149086845 scopus 로고    scopus 로고
    • Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
    • Characterization of FRC conduit in B cell follicles demonstrates that they are structurally similar to those in the T cell area. Follicular conduits are important for delivery of small antigens and B cell chemokine.
    • Roozendaal R., Mempel T.R., Pitcher L.A., Gonzalez S.F., Verschoor A., Mebius R.E., von Andrian U.H., and Carroll M.C. Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity 30 (2009) 264-276. Characterization of FRC conduit in B cell follicles demonstrates that they are structurally similar to those in the T cell area. Follicular conduits are important for delivery of small antigens and B cell chemokine.
    • (2009) Immunity , vol.30 , pp. 264-276
    • Roozendaal, R.1    Mempel, T.R.2    Pitcher, L.A.3    Gonzalez, S.F.4    Verschoor, A.5    Mebius, R.E.6    von Andrian, U.H.7    Carroll, M.C.8
  • 39
    • 0016762452 scopus 로고
    • Studies on the structure and permeability of the microvasculature in normal rat lymph nodes
    • Early identification of network of FRC fibers as conduits for delivery of small antigens into the T cell area.
    • Anderson A.O., and Anderson N.D. Studies on the structure and permeability of the microvasculature in normal rat lymph nodes. Am J Pathol 80 (1975) 387-418. Early identification of network of FRC fibers as conduits for delivery of small antigens into the T cell area.
    • (1975) Am J Pathol , vol.80 , pp. 387-418
    • Anderson, A.O.1    Anderson, N.D.2
  • 40
    • 0034693949 scopus 로고    scopus 로고
    • Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex
    • Elegant characterization of FRC conduits within peripheral LNs showing delivery of chemokines and small antigens from subcapsular sinus to HEV within the cortical zone.
    • Gretz J.E., Norbury C.C., Anderson A.O., Proudfoot A.E., and Shaw S. Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J Exp Med 192 (2000) 1425-1440. Elegant characterization of FRC conduits within peripheral LNs showing delivery of chemokines and small antigens from subcapsular sinus to HEV within the cortical zone.
    • (2000) J Exp Med , vol.192 , pp. 1425-1440
    • Gretz, J.E.1    Norbury, C.C.2    Anderson, A.O.3    Proudfoot, A.E.4    Shaw, S.5
  • 41
    • 12444297666 scopus 로고    scopus 로고
    • The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node
    • Immunochemical characterization of FRC conduits within LNs. Results support role of conduits in delivery of antigen to DCs.
    • Sixt M., Kanazawa N., Selg M., Samson T., Roos G., Reinhardt D.P., Pabst R., Lutz M.B., and Sorokin L. The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22 (2005) 19-29. Immunochemical characterization of FRC conduits within LNs. Results support role of conduits in delivery of antigen to DCs.
    • (2005) Immunity , vol.22 , pp. 19-29
    • Sixt, M.1    Kanazawa, N.2    Selg, M.3    Samson, T.4    Roos, G.5    Reinhardt, D.P.6    Pabst, R.7    Lutz, M.B.8    Sorokin, L.9
  • 42
    • 0141867750 scopus 로고    scopus 로고
    • Fluid and cellular pathways of rat lymph nodes in relation to lymphatic labyrinths and Aquaporin-1 expression
    • Ohtani O., Ohtani Y., Carati C.J., and Gannon B.J. Fluid and cellular pathways of rat lymph nodes in relation to lymphatic labyrinths and Aquaporin-1 expression. Arch Histol Cytol 66 (2003) 261-272
    • (2003) Arch Histol Cytol , vol.66 , pp. 261-272
    • Ohtani, O.1    Ohtani, Y.2    Carati, C.J.3    Gannon, B.J.4
  • 43
    • 33845455093 scopus 로고    scopus 로고
    • Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
    • Elegent study supporting a role for FRC fibers and 'highways' for lymphocyte and DC migration within peripheral LNs.
    • Bajenoff M., Egen J.G., Koo L.Y., Laugier J.P., Brau F., Glaichenhaus N., and Germain R.N. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25 (2006) 989-1001. Elegent study supporting a role for FRC fibers and 'highways' for lymphocyte and DC migration within peripheral LNs.
    • (2006) Immunity , vol.25 , pp. 989-1001
    • Bajenoff, M.1    Egen, J.G.2    Koo, L.Y.3    Laugier, J.P.4    Brau, F.5    Glaichenhaus, N.6    Germain, R.N.7
  • 44
    • 0037111219 scopus 로고    scopus 로고
    • Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice
    • Gadjeva M., Verschoor A., Brockman M.A., Jezak H., Shen L.M., Knipe D.M., and Carroll M.C. Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice. J Immunol 169 (2002) 5489-5495
    • (2002) J Immunol , vol.169 , pp. 5489-5495
    • Gadjeva, M.1    Verschoor, A.2    Brockman, M.A.3    Jezak, H.4    Shen, L.M.5    Knipe, D.M.6    Carroll, M.C.7
  • 45
    • 0242494429 scopus 로고    scopus 로고
    • Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection
    • Verschoor A., Brockman M.A., Gadjeva M., Knipe D.M., and Carroll M.C. Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection. J Immunol 171 (2003) 5363-5371
    • (2003) J Immunol , vol.171 , pp. 5363-5371
    • Verschoor, A.1    Brockman, M.A.2    Gadjeva, M.3    Knipe, D.M.4    Carroll, M.C.5
  • 46
    • 35348850794 scopus 로고    scopus 로고
    • The presence of MOMA-2+ macrophages in the outer B cell zone and protection of the splenic micro-architecture from LPS-induced destruction depend on secreted IgM
    • Fischer M.B., Ruger B., Vaculik C., Becherer A., Wadsak W., Yanagida G., Losert U.M., Chen J., Carroll M.C., and Eibl M.M. The presence of MOMA-2+ macrophages in the outer B cell zone and protection of the splenic micro-architecture from LPS-induced destruction depend on secreted IgM. Eur J Immunol 37 (2007) 2825-2833
    • (2007) Eur J Immunol , vol.37 , pp. 2825-2833
    • Fischer, M.B.1    Ruger, B.2    Vaculik, C.3    Becherer, A.4    Wadsak, W.5    Yanagida, G.6    Losert, U.M.7    Chen, J.8    Carroll, M.C.9    Eibl, M.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.