Histological and electron microscopic studies of the effect of β-carotene on the pancreas of streptozotocin (STZ)-induced diabetic rats

Pakistan Journal of Biological Sciences

Volumn 12, Issue 4, 2009, Pages 301-314

  Attia, Azza A ^a  

^a Alexandria University Faculty Of Science   (Egypt)

Author keywords

carotene; Antioxidants; Diabetes mellitus; Islets of langerhans; Oxidative stress; Pancreas; Streptozotocin

Indexed keywords

ANTIOXIDANT; BETA CAROTENE; STREPTOZOCIN; VITAMIN;

ANIMAL; ARTICLE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HUMAN; MALE; PANCREAS; RANDOMIZATION; RAT; ULTRASTRUCTURE;

ANIMALS; ANTIOXIDANTS; BETA CAROTENE; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; MALE; PANCREAS; RANDOM ALLOCATION; RATS; STREPTOZOCIN; VITAMINS;

GREAT ISLAND VIRUS; RATTUS;

EID: 67049086159     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2009.301.314     Document Type: Article

References (52)

1. Appel, M.J. and R.A. Woutersen, 1996. Effect of dietary β-carotene and selenium on initiation and promotion of pancreatic carcinogenesis inazaserine-treatedrats. Carcinogenesis, 17: 1411-1416.
2. Arulselvan, P. and S.P. Subramanian, 2007. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultrastructural changes of pancreatic-cells in experimental diabetes in rats. Chem. Biol. Interact, 165: 155-164.
3. Aughsteen, A.A., 2000. An ultrastructural study on the effect of STZ on the islet of Langerhans in mice. Elect. Microsc, 49: 681-690.
4. Bast A., G. Wolf, I. Oberbaumerand and R. Walther, 2002. Oxidative and nitrosative stress induces peroxiredoxins in pancreatic β-cells. Diabetologia, 45: 867-876.
5. Brosky, G. and J. Logothetopoulos, 1969. Streptozotocin diabetes in mouseand guinea pig. Diabetes, 18: 606-606.
6. Brownlee, M., 2005. The pathobiology of diabetic complications: A unifying mechanism. Diabetes, 54: 1615-1625.
7. Buncher, A. and L.M. Sreebny, 1970. Effect of prolonged food reduction on the rat parotid gland and exocrine pancreas. J. Nutr., 100: 655-655.
8. Burton, G.W. and K.U. Ingold, 1984. β-Carotene: An unusual type of lipid antioxidant. Science, 224: 569-573.
9. Chakrabarty, A., R.A. Norman and T.J. Phillips, 2002. Cutaneous manifestations of diabetes. Wounds, 14: 267-274.
10. Colditz, G., J. Manson, M. Stampfer, B. Ronser, W. Willett and F. Speizer, 1992. Diet and risk of clinical diabetesin women. Am. J. Clin. Nutr., 55: 1018-1023.
11. Cotran, R.S., V. Kumar and S.L. Robbius, 1994. Robbins Pathologic Basis of Disease. 5th Edn., WB Saunders Company, Philadephia, London, Toronto, Montreal, Sydney.
12. Drury, R.A.B. and E.A. Wallington, 1980. Carleton's Histological Techniques. 5th Edn., Toronto, Oxford, New York.
13. Edress, Z., I. Zaki, S. El-Kalawyee, S. Fawzy and M. Abd-El-Hafez, 1987. Effect of starvation on certain organs of albino rat. Egypt. J. Histol., 10: 193-193.
14. El-Feki, M.A., Z.A. Radwan, A.A. Abdel-Monaiem and E. Salah, 1997. Effect of Nigella sativa fish oil on alloxan giabetic rats, 2-Immunological studies. J. Egypt. Ger. Soc. Zool, 23: 166-186.
15. Evans, J.L., I.D., Goldfine, B.A. Maddux and G.M. Grodsky, 2003. Are oxidative stress activated signaling pathways mediators of insulin resistance and β-cell dysfunction? Diabetes, 52: 1-8.
16. Flament, P. and C. Remacle, 1987. Ultrastructural aspects of STZ in cytotoxicity on rat pancreatic islets in vitro. Test of a protective effect of zinc. Virchows Arch. B Cell Pathol. Zell Pathologie, 53: 107-112.
17. Florence, T.M., 1995. The role of free radicals in disease. Aust. N. Z. J. Ophthalmol, 23: 3-7.
18. Ford, E.S., C.W. Julie, A.B. Barbara and K.M. Venkat Narayan, 1999. Diabetes Mellitus and serum carotenoids: Findings from the Third National Health and Nutrition Examination Survey. Am. J. Epidomol., 149: 168-176.
19. Frusho, T., E. Kataoka, T. Yasuhara, M. Wada and S. Innami, 2002. Administration of beta-carotene suppresses lipid peroxidation in tissues and improves the glucose tolerance ability of streptozotocin-induced diabetic rats. Int. J. Vitam. Nature Res., 72: 71-76.
20. Ganda, O.P., A.A. Rassini, A.A. Like and C. Boston, 1976. Studies on streptozotocin diabetes. Diabetes, 25: 595-595.
21. Gandy, S.E., M.G. Buse, J.R. Sorenson and R.K. Crouch, 1983. Attenuation of STZ diabetes with superoxide dismutase like copper II in the rat. Diabetologia, 24: 437-440.
22. Glauert, A.M. and R.H. Glauert, 1958. Araldite as an embedding medium for electron microscopy. J. Biophys. Biochem. Cytol, 4: 191-191.
23. Hong, J.H., M.J. Kim, M.R. Park, O.G. Kwag and IS. Lee et al., 2004. Effects of vitamin E on oxidative stress and membrane fluidity in brain of streptozotoc in-induced diabetic rats. Clin. Chem. Acta, 340: 107-115.
24. Howarth, F.C., M.A. Qureshi, P. Lawrence and E. Adeghate, 2000. Chronic effects of STZ induced diabetes on the ultrastructure of rat ventricular and papillary muscle. Acta Diabetol., 37: 119-124.
25. Hruban, Z., H.D. Swift and D. Lewis, 1965. Effect of B-3-Furylalamine on the ultrastructure of the hepatocytes and pancreatic acinar cells. Lab. Invest, 14: 70-80.
26. Kakkar, R., S.V. Mantha, J. Radhi, K. Prasad and J. Kalra, 1998. Increased oxidative stress in rat liver and pancreas during progression of STZ-induced diabetes. Clin Sci., 94: 623-632.
27. Kataja-Tuomola, M., J.R. Sundell, S. Mannisto, M.J. Virtanen, J. Kontto, D. Albanes and J. Virtamo, 2008. Effect of alpha tocopherol and β-carotene supplementation on the incidence of type II diabetes. Diabetologia, 51: 47-53.
28. Kloppel, G., P. Heitz and W. Gepts, 1984. Pancreatic Pathology. Churchill Livingstone, Edinburgh, London, Melbourne, New York.
29. Kohlmeier, L. and S.D. Hasting, 1995. Epidemiologic evidence of a role of carotenoids in cardiovascular disease protection. Am. J. Clin. Nutr., 62: 13705-13765.
30. Krinsky, N.I., 1993. Actions of carotenoids in biological systems. Ann. Rev. Nutr., 13: 561-587.
31. Krishna, M.I. and U.N. Das, 2001. Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids. Nutrition, 17: 126-151.
32. Lee, S.H. and I.S. Park, 2000. Effects of soyabean diet on the beta cells in the STZ treated rats for induction of diabetes. Diab. Res. Clin. Pract, 47: 1-13.
33. Lee, S.H., Y.M. Han, B.H. Mm and I.S. Park, 2003. Cytoprotective effects of polyenoylphosphatidylcholine (PPC) on β-cells during diabetic induction by STZ. J. Histochem. Cytochem., 51: 1005-1015.
34. Liu, S., U. Ajani, C. Chan, C. Hennekens, J.E. During and J.E. Manson, 1999. Long-term beta-carotene supplementation and risk of type 2 Diabetes Mellitus. J. Am. Med. Assoc, 282: 1073-1075.
35. Mansford, K.R. and L. Opie, 1968. Comparison of metabolic abnormalities in diabetes mellitus induced by STZ or by alloxan. Lancet, 1: 1-1.
36. Maritim, A.C., R.A. Sanders and J.B. Watkins, 2003. Diabetes, oxidative stress and antioxidants: A review. J. Biochem. Mol. Toxicol., 17: 24-38.
37. Mayne, S.T., 1996. Beta-carotene, carotenoids, and disease prevention in humans. FASEB J., 10: 690-701.
38. Mythili, M.D., R Vyas, G. Akila and S. Gunasekaran, 2004. Effect of STZ on the ultrastructure of rat pancreatic islets. Microsc. Res. Technique, 63: 274-281.
39. Olefsky, T.M., 1992. Diabetes Mellitus in Cecil Textbook of Medicine. 19th Edn., WB. Saunders Co., Philadephia, London.
40. Olson, J.A. and N.I. Krinski, 1995. Introduction: The colorful, fascinating world of the carotenoids: Important physiologic modulators. FASEB J., 9: 1547-1558.
41. Paolisso, C., A. DAmore and G. Di Maro, 1993. Evidence for a relationship between free radicals and insulin action in the elderly. Metabolism, 42: 659-663.
42. Ramakrishna, V. and R. Jailkhani, 2007. Oxidative stress in non-insulin dependent diabetes mellitus patients. Acta Diabetol., 45: 41-46.
43. Reynolds, E.S., 1963. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol., 17: 208-212.
44. Sami, K.S., C. Thompson, CM. Wmterford, N.I. Walker and D.P. Cameron, 1996. Streptozotocin at low doses apoptosis and at high doses necrosis in a murine pancreatic beta cell line, INS-I. Biochem. Mol. Iliol. Int., 39: 1229-1236.
45. Schnedl, W. J., S. Ferber, J.H. Johnson and C.B. Newgard, 1994. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes, 43: 1326-1333.
46. Seddon, J.M., U.A. Ajani and R.D. Sperduto, 1994. Dietary carotenoids, vitamins A, C and advanced age-related macular degeneration. J. Am. Med. Assoc, 272: 1413-1420.
47. Snowdon, D.A. and R.L. Phillips, 1985. Does avegetarian diet reduce the occurrence of diabetes? Am. J. Public Health, 75: 507-512.
48. Sylvia, S.M., 1993. Biology. 4th Edn., Wm. C. Brown Publishers, Dubuque, Melbourne, Australia.
49. Szkudelski, T., 2001. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res., 50: 537-546.
50. 2 as mediator for DNA fragmentation. Diabetes, 40: 1141-1145.
51. World Health Organization, 2002. Diabetes mellitus. WHO Fact SheetNo. 138.
52. Xianwen, Y.I. and N. Maeda, 2006. a-lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high fat/low cholesterol diet. Diabetes, 55: 2238-2244.